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Path to deliverance from suffering

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By Dr. Justice Chandradasa Nanayakkara

The Buddha declared ‘the world is established on suffering, is founded on suffering’ (Dukke loko patititthhito). All problems in life bring about unsatisfactoriness as we attempt to put an end to them, they give rise to another. Solution of one problem leads to a another problem in many other diverse ways. We are constantly confronted with fresh problems in our daily life and problems go on incessantly and interminably. Such is the nature of suffering, and it is the universal characteristic of sentient existence. Suffering constantly appears and passes away only to reappear in other forms. Suffering and impermanence continually present challenges and people are faced with various life obstacles that are out of their control. Suffering can be either physical or psychological. Buddha declared everything subject to origination is subject also to dissolution”. The law of anicca or impermanent stipulates that all contingent existence is transitory. Nothing is in exact state it was in the previous instant and nothing remains the same for two consecutive moments. What is built eventually crumbles and fall, whoever is born will eventually die, and what comes together will eventually separate. Corona virus pandemic which is raging the whole world has brought in to sharp relief the fact of suffering. Dukka is inescapable and ubiquitous and it constitutes the first of the four Noble Truths in Buddhism. This does not mean every facet of life or every one of our experiences is miserable. Buddhism does acknowledge that life can be replete with pleasures and delights of various kinds. But they are ephemeral and impermanent.

In one of the discourses recorded in Anguttara Nikaya, the Buddha offers the following simile to explain the fleeting nature of human life. “Just as a dew drop on the tip of a blade of grass will quickly vanish at sunrise and will not last long, so too Brahmin, human life like a drop of dew, it is limited, brief and fleeting and it has much suffering, full of tribulation …. none who is born can escape death. Therefore, given the limited and fleeting nature of human life, it becomes important for Buddhists to tread the path leading to the deliverance from suffering.

In the first Noble truth, the Buddha defines the truth of dukka thus: “What monks, is the Noble Truth of Dukka? Birth is dukka, decay is dukka, death is dukka, sorrow, lamentation, pain displeasure and despair are dukka; union with the unpleasant dukka, separation from the pleasant dukka, not what one wants is dukka; in brief, the five aggregates of clinging are dukka. These monks, is the Noble Truth of Dukka”.

The solution for the aforesaid problems of dukka (unsatisfactoriness) of life is the Noble Eightfold Path propounded by Lord Buddha more than 2600 years ago. This is the only way to the cessation of suffering and also a vital step in emancipating ourselves from interminable cycle of rebirths.

It is said that this path leads to the cessation of dukka. This path consists of a set of eight interconnected factors or conditions, that when developed together, leads to the cessation of dukkha.

The eight factors of the paths are 1. Right Understanding (sammaditthi) 2. Right Thought (sammasankappa) 3. Right Speech (sammavacca). 4. Right Action (sammakammanta) 5. Right Livelihood (sammaajiva) Morality or Virtue Group sila 6. Right Effort, (sammavayama). 7. Right Mindfulness (samma sati) 8. Right concentration (samma samadhi).

These eight factors aim at promoting and perfecting the three essentials of Buddhist training and discipline. For the purpose for coherent and better understanding of the eight divisions of the path have been grouped according to under mentioned three heads.

The first two are classified as Wisdom (panna), the second three as Morality (sila) and the last three as Concentration (samadhi). These three stages in the Eightfold Path are encapsulated in a Buddhist stanza (sabba papassa akaranan – kusalassa upa sammapada – sacitta priyo dapanan – etan buddhanu sasanan). To ease from all evil to cultivate good to purify one’s mind that is the advice of all Buddhas.

The eight steps of the path are not expected to be realised in sequence, one after the other. Rather, they are considered a unity, an organic whole. They are interdependent and interrelated. All eight factors are preceded by the word “Right” classified as Right, which means perfect. It is a mode of transcendence and leads to the transcendence to arise, namely sotapanna sakadagami, anāgāmi and arahant. No doubt, it is a difficult feat to be achieved. The Noble Eightfold path is in effect the path to Nibbana., Which avoids the extreme of self-mortification that weakens the intellect and the extreme of self-indulgence that retards moral progress. Although it is generally spoken as a path to be treaded, in actual fact eight steps signify mental factors to be practised. All eight factors should converge simultaneously, each supporting other and reach a sufficient level of development to experience of sotapanna, sakadagame, anāgāmi or arahant. It is said the path proceeds from a lower state of purity to higher state and factors of the path should coalesce at a certain level of perfection. Path is not meant to be practiced a little each day.

According to Walpola Rahula, the divisions of the Noble Eightfold Path s should be developed more or less simultaneously, as far as possible according to the capacity of each individual. They are linked together and each helps the cultivation of the others.

As far as the Right Understanding in Wisdom group of the Noble Eightfold Path is concerned it is the understanding of things as they really are, particularly the clear comprehension of the Four Noble truths. The Right Understanding has been treated as the first step as an intuitive understanding as it provides the necessary motivation and impulse to start on the Eightfold Path. Importance of understanding in general sense can be seen from the Buddhas own statement.

“Do not be guided by hearsay or by tradition, legendary lore or what has come down in holy scriptures; nor on grounds of reason or logical inference; nor because of preconceived opinions or simple likelihood, nor because of a teacher’s authority. Only when you know for yourselves: these things are good and beneficial, are praised by the wise, and when taken up and carried out lead to welfare and happiness-then you should make them your own and live in accordance with them Anguttara Nikaya.”

Right Thought in the Wisdom group is threefold and it denotes the thoughts of selfless renunciation or detachment, thoughts of love and thoughts of non violence, which are extended to all beings. Cultivation of such thoughts enables a person to act accordingly at the appropriate time. One should practices benevolence and goodness in relation to indifferent people as well as those who are inimical or unfriendly. Persons should not entertain thoughts of selfish desire, ill will hatred and violence in all spheres of life whether individual, social or political.

Next group is Morality (Sila), based on love and compassion, in which are included three factors of the Noble Eightfold Path: namely Right Speech, Right Action and Right Livelihood. (Nos. 3, 4 and 5 in the list).

Right speech means abstention (i) from telling lies, (2) from backbiting and slander and talk that may bring about hatred, enmity, disunity and disharmony among individuals or groups of people, (3) from harsh, rude, impolite, malicious and abusive language, and (4) from idle, useless and foolish babble and gossip. When one abstains from these forms of wrong and harmful speech one naturally has to speak the truth, has to use words that are friendly and benevolent, pleasant and gentle, meaningful and useful. One should not speak carelessly: speech should be at the right time and place. If one cannot say something useful, one should keep ‘noble silence’.

Right Action aims at promoting moral, honourable and peaceful conduct. It admonishes us that we should abstain from destroying life, from stealing, from dishonest dealings, from illegitimate sexual intercourse, and that we should also help others to lead a peaceful and honourable life in the right way.

As far as the Right Livelihood, in the Noble Eightfold is concerned, it should be stated that Lord Buddha has not expatiated much on it,. As the major part of one’s daily life is taken up by one’s employment, the way one earns his or her livelihood has ethical and social implications either positive or negative. Buddha simply declared that a layman should not pursue certain trades which are considered to be morally and ethically wrong. For this purpose, he listed five trades which he considered to be inimical and harmful to the people and the society. They are trading in poison, trading in weapons, trading in meat, trading in intoxicants and trading in humans (diganikaya).

However, these forbidden trades are the very ones that have increased phenomenally as a result of the free marketing forces and globalisation in the world today.

Next stage is concentration (samadhi) group which Embodies three other factors of Noble Eightfold Path namely Right Effort, Right Mindfulness, and Right Concentration.

These three factors Right Effort, Right mindfulness, and Right Concentration constitute mental culture or concentration. Together these three steps encourage and enable one to be self-reliant attentive and calm. Right effort means undertaking our tasks with energy and vigor with a will to carry them through.

Right Effort (sammavayama) in general sense means cultivating positive attitude towards whatever we undertake to do. It means undertaking our tasks with enthusiasm and energy with a will to carry them through. In other words, if we fail to put effort into whatever we do, we cannot hope to succeed. But the effort must be controlled and balanced so that effort should not become too tense or too extreme. Similarly, it should not become too slack and not abandoned. Right effort (sammavayama) involves persevering four great efforts”. (1)The effort to avoid the arising of evil, unwholesome thoughts that have not arisen ye, by exercising right restraint of the senses and self-control, (2) the effort to overcome, to dispel quickly evil, unwholesome thoughts that have already arisen. (3) the effort to develop noble wholesome thoughts that have not yet arisen, (4), the effort to maintain noble, wholesome thoughts have already arisen Therefore, it is evident that the function of the right effort is to maintain constant endeavor and diligence in checking unhealthy thoughts, and to cultivate, promote and maintain wholesome and pure thoughts.

The second step of the Noble Eightfold Path that is embodied in the category of Concentration (mental development) is Right Mindfulness. Right Mindfulness is essential in our ordinary mundane activities. Mindfulness simply is awareness or attention avoiding a distracted and clouded state of mind.

It should be noted Right Mindfulness is the basis for all of the other components on the path. Unless one is mindful, there cannot be a right view, intention, speech, action livelihood, effort and concentration. Mindfulness is all about presence of mind and paying attention to what is happening in the present moment. Mindfulness leads to serenity, insight, deep concentration or wisdom. It does not lead to undirected unguarded thoughts. Right mindfulness is developing an accurate and precise awareness of the present moment unclouded by ideas beliefs, memories and expectations.

Right mindfulness is essential requirement in our daily life. Mindfulness simply is awareness or attention, avoiding a distracted and clouded state of mind. This would be necessary even in our ordinary mundane activities. For example, when a person is driving a vehicle, or crossing a busy street or doing some other task which requires attentiveness if one is unmindful of what one is doing there bound to be mishaps. It should stated that most of the majors traffic accidents that occur in Sri Lanka is due to lack of mindfulness. Therefore, practice of mindfulness plays an important role in our day today activities as enunciated in buddhism. The practice of mindfulness has been, developed to include four particular applications. They are application of mindfulness with regard to body (kayanupassana), (b) feelings or sensations (vedanupassana), (c) states of mind (cittanupassana) and (d) mental objects (dammanupassana). The discourse on “The Setting Forth of Mindfulness” (Satipatthana sutta) deals dials with it.

Right Concentration is the steady fixing of the mind on a single object to the exclusion of all others. This is call samadhi or one-pointedness of the mind. The practice of concentration helps us to maintain the mind in a state of balance. It also refers to the sphere of meditation, and specially to the four jana (absorption). Meditation in Buddhism is classified into two systems, concentration of mind (samatha) and insight (vipassana) of these two, concentration has the function of calming the mind.

According to Buddhism there are forty subjects of mediation which differ according to the temperaments of individuals.

It is said that before practising samadhi an aspirant should select carefully the subject of meditation. In the past, it was customary for aspirants who are bent on meditation to seek guidance of a competent teacher to choose suitable subject according to his temperament.

–– Ven. . Naradha



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‘A remarkable time capsule’: The enchanting history of Oxford University’s 750-year-old medieval library

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Predating the Aztec Empire, Merton College Library in Oxford has been used by everyone from celebrated 14th-Century mathematicians to JRR Tolkien. In an exclusive interview with the BBC for its 750th birthday, its librarian describes what makes it so special.

At Merton College in Oxford, there is an antique chest. In the Middle Ages, three key-holders had to be summoned to reveal the riches within. But this treasure wasn’t gold or jewels. It was books.

Such strict security may sound overly cautious for mere parchment. But in an era before the printing press, books were a valuable commodity. They could take months to produce, as the entire text had to be painstakingly written out by hand. So, just as universities solicit cash from their alumni today, Merton College insisted its 13th-Century fellows donated books.

“There’s no single definition of a library” – Prof Teresa Webber

The Archbishop of Canterbury issued a decree in 1276 introducing this requirement, which marked the beginning of the library at Merton College. It has been running continuously ever since. To put that length of time in context, Merton’s library predates the Aztec Empire. Its unbroken history stretches from before the Black Death to beyond the Covid-19 pandemic. And its users have encompassed everyone from famous 14th Century mathematicians to Lord of the Rings author JRR Tolkien.

This month marks the library’s 750th anniversary. It’s a major milestone. But Merton’s extraordinary lifespan has been recognised since the Victoria era, when it was routinely described as the oldest library in England.

In the 20th Century, writers like Rudyard Kipling and John Buchan referenced it in works of historical fiction, bolstering its reputation as a particularly venerable library. As the cultural recognition of “the famous Merton Library” grew, claims about its longevity became exaggerated. Some overzealous Oxonians even declared it the oldest library in the world.

The origins of the historic library

Historians today are more careful about making such bold declarations. “It’s a complicated question,” says Prof Teresa Webber from the University of Cambridge. “There’s no single definition of a library. And there were all sorts of stages in the development of what we think of today as a library.”

Courtesy of the Warden and Fellows of Merton College Oxford Dr Julia Walworth is Merton College's librarian (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)
Dr Julia Walworth is Merton College’s librarian (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)

 

The origins of the library at Merton are certainly different from how we think of such institutions now. There was no librarian and there were no shelves for browsing. “There was a system of loaning and returning books from the chest,” Merton’s librarian, Dr Julia Walworth tells the BBC. “It would have been a formal thing. Rather than just saying, ‘Oh, go rummage and find the books you need,’ the whole community would come together to open the chest.”

“Horizontal shelves were installed for placing books upright. Merton is the first recorded use in Britain of this method of storing books” – Dr Julia Walworth

Merton’s collection started evolving into a modern library quite quickly. Just a few years after the Archbishop’s decree, several books were stored outside the chest for the first time. They were chained to a table in the college, making them available at any time. According to Walworth, this innovation “anticipates the modern distinction between loan and reference library collections”.

Merton’s book treasury moved closer to becoming a modern library in the 1370s, when a purpose-built room was constructed to house the growing collection. It was here that Merton introduced a vital improvement in book storage. “Horizontal shelves were installed for placing books upright,” Walworth says. “Merton is the first recorded use in Britain of this method of storing books.”

Curiously, Merton’s books were shelved with their spines inwards and their titles inked on the paper facing out. This was due to the continued use of chains, which were clipped on the fore-edge of each book’s cover. “The fellows were aware that chained books had a better chance of survival than books that went out on loan,” Walworth explains.

Courtesy of the Warden and Fellows of Merton College Oxford The historic library is the university's oldest – one of the oldest functioning academic libraries in Europe (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)
The historic library is the university’s oldest – one of the oldest functioning academic libraries in Europe (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)

 

Today, just a few volumes in the library are chained – purely for display purposes. And the remaining books are now placed in the modern fashion with their spines out. But otherwise, the medieval room remains a remarkable time capsule of the library’s history. Near the entrance, visitors can even see the 13th-Century chest, which Walworth believes is the original. During term time, the historic library room is still used by students. And this ongoing use is a major factor in the superlatives that are often applied to the age of Merton’s library. “It’s hard to think of an earlier library room that’s been in continuous use,” Webber says.

Claims about Merton’s longevity first gained traction in the Victorian era, as it became more of a tourist destination. Visitors would marvel at its stained-glass windows, as well as rare books like its 15th-Century edition of The Canterbury Tales. “It’s one of the earliest books printed in England,” Walworth explains. “What’s unique about Merton’s copy is the hand-illuminated borders.” Among those who visited the library was American writer Ralph Waldo Emerson, who mentioned it in his 1856 travelogue English Traits. In 1884, a young Beatrix Potter visited, describing the library’s “beautiful oak roof” and “ancient, dusty smell” in her diary.

By this time, books and magazines were increasingly describing the library in record-breaking terms. An 1878 guide to Oxford called Merton’s library “the most ancient now in England”. The 1885 edition of the Encyclopaedia Britannica described it as “the oldest existing library in England”. Gradually, these claims were inflated. A 1928 article in The Times recounted an event held by the Oxford Preservation Trust in which it was declared “the oldest library in the world”.

Courtesy of the Warden and Fellows of Merton College Oxford The library contains rare, medieval manuscripts – including a 15th-Century edition of The Canterbury Tales (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)
The library contains rare, medieval manuscripts – including a 15th-Century edition of The Canterbury Tales (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)

 

This growing perception of Merton’s longevity was even referenced in F Scott Fitzgerald’s classic novel The Great Gatsby. In the book, the multi-millionaire title character fills his mansion with imitations of history’s most prestigious rooms. So, it’s only natural that his books live in a recreation he refers to as “the Merton College Library”. As Walworth puts it, “Merton’s library had become a byword for the ‘best’ ancient library” by that time. She even points out that Fitzgerald’s fictional scenario had roots in reality. “The dining clubs at Princeton University have historical imitation rooms. One of them is based on the Merton College Library.”

But today, Walworth rebukes any suggestion that Merton’s library is the world’s oldest. She prefers to describe it with several qualifiers, calling it “one of the oldest still-functioning academic libraries in Europe”. That more measured description recognises that not all historic libraries can be categorised in the same bucket – monastic libraries functioned very differently from private subscription libraries, for instance. But it also acknowledges ancient institutions around the globe. “It’s not that people weren’t aware of other parts of the world in the past,” Walworth says. “But there was a tendency for people to think of their own world as having primacy. Our outlook tends to be more global now, quite rightly.”

The debate over the world’s oldest library

Among these global institutions, there are several candidates for the contested title of world’s oldest library. When the Al-Qarawiyyin library in Morocco underwent a major restoration in 2016, it was described by several media outlets as “the oldest library in the world”. But Guinness World Records cites Saint Catherine’s Monastery in Egypt as the oldest continuously operating library.

Alamy Guinness World Records cites Saint Catherine's Monastery in Egypt as the world's oldest continuously operating library (Credit: Alamy)
Guinness World Records cites Saint Catherine’s Monastery in Egypt as the world’s oldest continuously operating library (BBC)

 

In both cases, it’s difficult to establish an exact starting date. For the Al-Qarawiyyin library, some scholars have cast doubt on the library’s claims of Ninth-Century origins, saying the “story has much myth about it”. In the case of Saint Catherine’s Monastery, the building was constructed in the Sixth Century. But ancient writings suggest that the library’s collections could date from two centuries earlier. “It depends how you count it,” Walworth says. “When are you going to start the timeline? What is the beginning of a library?”

However, Prof Richard Gameson from Durham University tells the BBC that the library at Saint Catherine’s Monastery “is probably the one with the longest continuous history”. But he caveats this by adding that “the nature of the ‘library’, how it was used and how it was understood changed over time”. So, any claim to be “the oldest” needs to be accompanied by an appropriate explanation of what a library is. Finding a single definition that allows for one conclusive record-holder seems a near-impossible task.

“You can think of the oldest library as the oldest coherent collection of books that stayed together,” says Webber. “Or you can think of it in terms of the survival of the physical space. Or you could ask, ‘What’s the oldest space and collection of books which has been there continuously?'”

She offers the Dunhuang Library Cave in China as an example. This secret chamber was filled with manuscripts and sealed sometime around the 11th Century. It was only opened again after its rediscovery in 1900. “But the books were still in continuous storage there,” Webber says.

Alamy The secret chamber in the Dunhuang Library Cave in China was filled with manuscripts and sealed around the 11th Century (Credit: Alamy)
The secret chamber in the Dunhuang Library Cave in China was filled with manuscripts and sealed around the 11th Century (BBC)

 

Finding a common definition of a library will only become more challenging now, as digital institutions offer physical spaces that do not even contain any books.  “The definition of what a library is has always needed to be a capacious one,” says Webber. “The introduction of new technology is simply a continuation of that. But I don’t think the library as a physical space will disappear.”

Walworth is similarly optimistic, as she embarks on a project to digitise Merton’s manuscripts. “People will be able to access them anywhere. But I think they will still want to come and see the library and understand how people used books in the past.”

Reflecting on the 750-year span of Merton’s library, this digital phase seems like just another step in a long evolution. Just as the books moved from the Archbishop’s chest to chained desks to horizontal shelves, now they will enter the virtual realm. “I suppose that’s why I now find it less useful to talk about libraries as ‘the oldest’,” Walworth says. “For me, the story is not about how long a library has been running. It’s more about the sense of community.”

She points out that the tradition of donating books introduced by the Archbishop of Canterbury in 1276 persists to this day. “What started when he laid down those injunctions was the idea of a common collection built by the people. So, it’s just remarkable that for 750 years people have maintained this connection with an institution and its books.”

Perhaps that proves that books really are the most durable treasure – whether they are handwritten on parchment and sealed in an antique chest or distributed as pixels in the cybernetic ether.

[BBC]

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Discovery of molecular structure of primary genetic material of life

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World DNA Day falls on 25 April:

On 25 April 1953, Watson and Crick published an article, in the acclaimed journal “Nature” titled “Molecular structure of nucleic acids: A structure for deoxyribonucleic acid”.

The one-page article largely based on theoretical arguments and the previous work of Rosalind Franklin who examined DNA using X-rays, changed the world forever by explaining how genetic information is copied and transmitted.

Everyone concerned with promoting science in the country should be aware of the story behind the discovery of DNA and tell it to their children and students and remind the policymakers.

The world commemorates the transformative event on 25th April every year. An example vividly illustrates how intense curiosity and imagination, rather than mere indulgence in technologies, leads to groundbreaking discoveries.

DNA Day is also intended to celebrate the completion of the Human Genome Project in 2003. Genome means the entire set of genetic information characterising an organism.

Heredity and inheritance

Heredity is the cause of transferring traits from parents to their offspring. The closely related word “inheritance “refers to the specific nature of the transmitted trait. For example, we say intelligence is hereditary in their family and he inherited his father’s intelligence.

The resemblance of progeny to parentage was common knowledge, taken for granted and considered a blending of maternal and paternal traits. Philosophers of antiquity proposed several theories to explain the inheritance of parental traits by the offspring. Hippocrates believed the essence of all body parts of the parents are incorporated into the male and female germinal essence and therefore the offspring display characteristics as a proportionate blend. Aristotle offered a different explanation. He argued that the active principle is in the male seminal fluid and the mother’s blood provided the original body material. The inaccuracy of these theories was apparent. Sometimes children possess qualities akin to grandparents rather than parents. Fathers or mothers of humans and animals, deformed by accidents or disease, gave birth to normal children- a clear proof that the acquired characters are not inherited. Children of a blue-eyed mother and a brown-eyed father have either blue or brown eyes but not a blend of blue and brown.

Two golden sayings in our culture, “Arae gathi nare” and “Jammeta wada lokuei purrudha” (“Hereditary characters persist” and “Habits overtake heredity “), agree more with modern genetics, than the views of Hippocrates and Aristotle.

Gregor Mendal’s groundbreaking experiment

The Austrian mathematician cum botanist, Gregor Mendel was the first to conduct a systematic investigation to understand the cause of heredity. Being unconvinced of the traditional explanations, he carried out a series of experiments lasting eight years to determine how the traits (plant height, seed color, flower color etc.) of pea plants are transmitted from generation to generation. When Mendel cross pollinated tall and short plants, he found that the progeny was entirely tall. However, when first generation tall plants were allowed to self-pollinate, the missing short trait reappeared at a statistically significant probability of 25 percent. Mendel’s work provided an unequivocal proof that traits do not blend but exist as unique entities, manifested from generation to generation following a predictable mathematical pattern.

Mendel’s finding remained unrecognized for more than 30 years. His ideas were too far ahead of time and biologists were shy of mathematics. In the early 1900s several European botanists arrived at the same conclusion based on independent experiments. With the advancement of microscopy, a great deal of information about plant and animal cells was gathered. A key finding was the presence of colored bodies in the cell nucleus named chromosomes, seen separating during cell division, leading to the hypothesis that Mendel’s genetic units (genes) should be physical entities present in the chromosomes.

Chemists and biologists wondered what the genetic material in chromosomes made off. Is it a protein, carbohydrate or a lipid? Most biological materials are constituted of these substances.

Discovery of DNA

Great discoveries are made by unusual people. The Swiss Friedrich Miescher belonged to a clan of reputed physicians. Following family tradition, he qualified as a doctor but did not engage in profitable practice of medicine. He decided to do research to understand the foundations of life. In search for new biological substances, he experimented with pus deposited in bandages and extracted a substance rich in phosphates but very different from proteins. The new substance called “nuclein” was indeed DNA. Later, the German biochemist Albrecht Kossel following the Miescher’s work, showed that DNA contains four crucial compounds, adenine (A), cytosine (C), guanine (G) and thymine (T), known as nucleotide bases.

Avery – MacLeod – McCarthy Experiment

The flu pandemic of 1918 killed an estimated 50 million people worldwide due to the pneumonia that followed the viral infection. Pneumonia was caused by the virulent bacterium Streptococcus pneumoniae. The British bacteriologist, Frederick Griffith attempting to find a vaccine for pneumonia, worked with two strains of Streptococcus pneumoniae, one virulent causing pneumonia in mice, and the other avirulent to them. He found that neither the virulent strain denatured by heating nor the live avirulent strain injected into mice caused the disease, whereas a mixture of the denatured virulent strain and the live avirulent strain was deadly to mice just as the virulent one. He concluded that some chemical compound present in the virulent strain – a transforming principle – has changed the avirulent strain to the virulent strain.

In 1944, Oswald Avery, Colin MacLeod and Maclyn McCarty working at the Rockefeller University, United States, continued the work of Frederick Griffith to identify the transferring principle and found that it is not protein as widely believed, but deoxyribonucleic acid (DNA). Their result pointed to the conclusion that DNA is the carrier of genetic information.

A book by a physicist that triggered a transformation in biology

The insights of brilliant brains engaged in fundamental inquiry have opened the way for major scientific discoveries and technological innovations. In 1944, the Austrian theoretical physicist Erwin Schrodinger, one of the founders of quantum mechanics, published a book titled “What is life? The physical aspect of the living cell “. The American biologist Maurice Wilkins said he was so inspired by Schrodinger’s book and after reading it, he decided to switch from ornithology to genetics. While physicist Maurice was influenced to take up biology. Francis Crick was a physicist working on magnetic mines for the British Admiralty during the war. After reading “What is life” he thought a physicist could find treasures in biology and joined the Cavendish Laboratory in Cambridge to pursue a Ph.D.

Structure of the DNA molecule

When DNA was shown to be the molecular entity that encodes genetic information, chemists rushed to determine its structure.

The pattern formed when X-rays passing through a material cast an image on a screen, provides information about its molecular structure. In 1938, the English physicist William Astbury examined DNA using x-rays and concluded that the molecule has a helical structure. Having heard a group in the United Kingdom was attempting to unearth the structure of DNA, the American theoretical chemist, Linus Pauling, adopted Astbury’s data and proposed a model for the structure of DNA, publishing the results in the journal “Nature” in January 1953.

There was an obscure but remarkably talented person, Rosalind Franklin, pursuing x-ray diffraction studies on DNA at King’s College London. After a painstaking effort, she obtained accurate x-ray diffraction images of DNA. Her colleague, Maurice Wilkins, working in the same laboratory, passed the images to Francis Crick and James Watson at Cavendish Laboratory.

Crick and Watson were more insightful and theoretical in their approach to elucidating the structure of DNA. They, inspired by Erwin Schrodinger’s hypothesis, that the entity accounting for heredity should be an aperiodic molecular entity in cells, arrived at the double helix model, showing that Linus Pauling’s model was erroneous. The Crick – Watson model explained how DNA stores information and replicates during cell division. Their assertions were subsequently confirmed rigorously by experimentation. Crick, Watson and Wilkins received the Nobel Prize for Physiology and Medicine in 1962.

The work following the Crick – Watson model, firmly established that the DNA is a polymer string constituted of two strands made of a sugar- phosphate backbone, connected to each other by linkage nucleotide bases A, T, G, C. The base A links base T and G to C. When one strand is defined by the arrangement of bases, the complementary strand is defined. The arrangement bases store information analogously to a four-letter alphabet. Each individual in a species has a unique sequence of arrangement base pairs. The variation within the species is generally a fraction of a percent.

The Watson-Crick model also explained how the DNA molecule replicates. The two strands unwind and separate, and two complementary strands are inserted. The detailed dynamics of the replication process are not fully understood.

‘DNA is a cookbook’

DNA functions like a multiple – volume cookbook, written in a four-letter alphabet. The volumes are kept in a rack in the kitchen. The rack is the nucleus and volumes on it are the chromosomes, and the cell is the kitchen. A paragraph giving a recipe is a gene. Enzymes act as chefs, who read recipes and give instructions to cell machinery to prepare the dishes, which are proteins. The system is so complex; a complete macroscopic analogy would be impossible.

The significance of the Crick- Watson work

Until Charles Darwin proposed the idea of evolution, biology lacked a theoretical foundation. Darwin hypothesized, when organisms reproduce, the progeny inherit parental characters, but there are variations. The variants, though similar to the parents, have some new or altered characters. If these characters, originating from mutations or cross – breeding are favorable for survival in the environment, they dominate in the population, inheriting advantageous traits. Thus, random generation – to – generation, advancements of living organisms, become possible – a way of improving the design of things in a production process without a designer. Living systems store information and progeny retrieve them, when required. A bird hatched from an egg when matured, knows how to fly.

The discovery of DNA and understanding how it stores genetic information, replicates and mutates explained Darwinian evolution. A mutation is a change in the ordering of base pairs, accidentally during replication or due to external chemical or physical causes. In sexual reproduction, the offspring gets nearly half of its DNA from each parent. Consequently, the offspring does not have DNA identical to one parent. It mixes up DNA in the species. However, mutations generate new genes, driving evolution. Sexual reproduction and mutation acting in concert introduced the diversity of life on earth we see today.

Once science becomes explanatory and predictive, it opens the way for innovations. Theories of mechanics and electromagnetism formulated in the late 19th and early 20th centuries brought forth modern engineering, transforming it from an empirical craft to a scientific technological discipline. Before the discovery of DNA structure and its function, biological innovations were largely empirical. Today we have genetic engineering – genes in organisms can be manipulated. The goal of more advanced genetic engineering, referred to as synthetic biology, aims to induce major genetic changes to organisms by incorporating several genes to alter biochemical, physiological and anatomical functions. Gene technology is rapidly transforming medicine, agriculture and biotechnology. Cures have been found for diseases formerly branded incurable.

How did DNA come into existence

Life is believed to have originated in prebiotic oceans enriched with carbon and nitrogenous substances. How did DNA originate there? Today, chemists can synthesize DNA in minutes, via selective procedures, only humans can do with their knowledge. Even in a vast ocean containing trillions of times more molecular ingredients than in a test tube, a molecule as complex as DNA is most unlikely to be created by random events during the largest possible time scales of the universe. A plausible scenario would be DNA evolving from simpler self-replicating molecules such as RNA (a single strand of DNA) precursors. Unlike RNA, DNA is highly stable and good stability is necessary for the evolution of advanced forms of life.

Epigenetics

Earlier we pointed out there are two golden sayings in our culture: “Arae gathi nare” and “Jammeta wada lokuei purudha (“Hereditary characters persist” and “Habits overtake heredity “). The first is a consequence of our genetic predisposition determined by DNA and explicit genes. However, the character of an individual is also influenced by the physical, social and cultural environment. Although completely non-genetic, our children frequently follow habits we indulge in. Again, the behavior of an individual is also influenced by the physical, social and cultural environment.

The environmental factors also trigger or silence genes. The study of this important genetic effect, which does not alter the sequence of base pairs, is referred to as epigenetics. Epigenetic effects could be deleterious or beneficial. Sometimes, chronic stress causes disease, including cancer. Research suggests engagement in creative and imaginative activities, and establishes favorable epigenetic changes in the brain. Inheritance is dictated mainly by the arrangement of base pairs in DNA. Epigenetic changes involve chemical changes in DNA without altering the sequence. These alterations are erasable but allow transmission to subsequent generations.

Conclusion: World DNA day message to lawmakers

The discovery of the structure of DNA stands as one of the most significant scientific discoveries in human history. It is a lesson to all those involved in research and education, telling how great discoveries originated. It is intense curiosity, imagination and preparation rather than mere indulgence in technologies that clear the path for discovery and innovation. A society that advocates policies conducive to discoveries, also develops new technologies that follow. If we just borrow technologies from places where they originated, hoping for quick economic returns, the effort would be a gross failure. Students, determined to be the best judging from exam performance, engage in professional disciplines and perform exceptionally. Why are we short of discoveries and innovations in those disciplines? Will our lawmakers ever realize the issue? They need to wonder why we are weak in science and poor in innovation. Right policies can even reverse adverse epigenetic attributes propagating in a society!

By Prof. Kirthi Tennakone
ktenna@yahoo.co.uk
National Institute of Fundamental Studies

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Features

Death of the Sperm Whale

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REVIEWED BY Prof. Rajiva Wijesinha

Earlier this year, I sent her most recent book by an old friend, Kamala Wijeratne. Death of the Sperm Whale is her first book of poetry in four years, though in between she has published fiction, two books though both of them too were slim volumes. I am full of admiration for her in that she keeps going, the last of the poets whom I helped to a wider readership in the eighties, when I championed Sri Lankan writing in English, something hardly any academic was prepared to do in those conservative days.

Kamala Wijeratne

Kamala’s subjects are those she has explored in the past, but the use of the plural indicates that her range is expansive. She dwells much on nature, but she deals also with political issues, and engages in social criticism. There are several poems about Gaza, the multiple horrors occurring there having clearly affected her deeply. She repeatedly draws attention to the slaughter of children, the infants sent by God only to be taken back. And she deals with the destruction of the life of a doctor, after his healing, a theme that has kept recurring in the ghastly world which is subject to the whims of the incredibly nasty Netanyahu.

The title poem is about a whale destroyed by ingesting plastic, a tragedy to which we all contribute, though those who ‘loll on the beach, their senses dulled by the burgers they eat’ could not care less. More immediate is the simple account of a friend whose infant had died in hospital, when they diagnosed pneumonia too late.

Contrasting with these urgent statements are Kamala’s gentle perceptions, as when she writes of her son supporting her as she walks, while she thinks back to the days she supported him; of a marigold growing in a crack in a shrine, offering obeisance with its golden flowers to the Noble One; of birds investigating her dining room and deciding not to build there, the male lingering ‘confused and irritated’ but eventually following the female through the window for ‘She was mistress after all.’

She is deeply interested in the passing of time, and its impact on our perceptions. The first poem in the book is called ‘First Poem of 2024’ when she ‘heard the weeping of the dying year’, and went on to meditate on how we have categorised the passing of time, while the universe moves on regardless.

She welcomes the return of the Avichchiya, the Indian Pitta, a bird that has figured previously in her poetry, after six months, but this time she spares a thought for his case against the peacock, which stole his plumes.

There are two personal poems, one about a former student who turned her back on her when she had achieved success, the other about being nominated for a literary award, but not getting it after the excitement of attending the Awards Ceremony. Swallowing her disappointment, she congratulates the winner, noting that she will not go into ecstasies the next time she is nominated.

Paraphrase cannot do justice to Kamala Wijeratne’s gentle touch, which has expanded its reach over the years. So,A I will end by quoting from her tribute to Punyakante Wijenaike, another of the distinguished ladies whose work I promoted, the one before the last to leave us. The tribute ends, recalling her most impressive work Giraya,

Like the nutcracker
That makes a clean cut
You cut the human psyche
To reveal its darkest depths

by Kamala Wijeratne

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