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ARTI or Peradeniya University? – career dilemmas of a young man

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by Jayantha Perera

In 1971, after the failed Marxist uprising against the state, the government introduced the rule that anyone applying for a government job should get a report (a ‘chit’) from the local political agent of the government. This rule especially applied to young men and women, as the government distrusted the youth because of their involvement in the insurrection.

Soon after graduating from the University of Peradeniya in 1972, I applied for a vacancy at the Agrarian Research and Training Institute (ARTI) for a research and training officer (rural sociology). I visited the political agent, who lived in Hendala, to get a chit. The agent was an Ayurvedic doctor who was also a justice of the peace and a member of the Town Council (He was known as ‘Member Mahatmaya.’). He cordially received me in the verandah of his small house. He was in a sarong without a shirt or a vest. A heavy leather belt with a large buckle was around his belly over the sarong. A small towel covered his shoulders.

He complained that my late father had never even said hello to him. I just kept quiet. He then added, “Never mind. People say he was an outstanding teacher. That matters. You know, different people have different personalities.” Then he enquired about what had brought me to him. I told him I had applied for a staff position at the ARTI and needed a good recommendation from him. He smiled and said, “Yes, every day, I get one or two inquiries about job applicants from government ministries. I will send a good recommendation if the Ministry requests me to send a report on you. Please do not forget to say hello when we meet again.”

Mahinda Silva, the Ministry of Agriculture and Lands Secretary, chaired the interview panel. He welcomed me and asked, “Do you want us to interview you in English or Sinhala?” I replied, “In both.” Mahinda chuckled and said, “Alright, we’ll start with a few questions in English and then switch to Sinhala.” The interview focused on collaborating with economists, agronomists, and communication specialists in sociological studies. I used the term “social structure” several times. Mahinda encouraged me to elaborate my thoughts without using abstract concepts, inspiring me to express myself more clearly.

Two weeks later, the ARTI Registrar told me to meet Mahinda. I found Mahinda in the ARTI Chairman’s office, an air-conditioned room with comfortable chairs and a large desk. A peon with a colourful sash and an apron served tea with biscuits, butter cake, and devilled cashew nuts. I sat on the edge of a chair, scared to sit back in such an august environment. Mahinda asked me about my school, family background, and teachers he knew at the university while going through some files.

He asked me whether I wanted to join the ARTI. I said, “Yes, Sir.” Mahinda smiled and got up with some papers in his hand. He was a tall man, dark in complexion. He was in his fifties. He wore a long-sleeved white shirt with a pair of baggy white trousers. I noted that he wore sandals, not socks and shoes. He had a disarming smile, which made me comfortable. He told me that the ARTI was a new institute. I should get ready to do postgraduate studies in England.

I told Mahinda what the political agent had told me. He laughed and said the Honourable Minister was a progressive man who did not rely on political chits to appoint deserving candidates to staff positions. He then asked me if I had any connections with the Janatha Vimukthi Peramuna (JVP) party, which led the 1971 insurrection. I explained that I was the Vice President of the University’s Communist Party (Peking Wing) and was involved in student politics but had no ties with the JVP. Mahinda said, “Your involvement in student politics is a sign of your leadership.” This acknowledgement of my leadership skills made me feel trusted and empowered.

Mahinda came to the ARTI with the Minister to meet the new recruits. He outlined critical research issues in the agrarian sector, including rural landlessness, poverty among agricultural wage workers, and undeveloped rural markets. The Minister told us, “We all should try to find solutions to such issues, and I know the ARTI can play a vital role. We provide vehicles, international advisers, and facilities to do research.”

In early May 1974, six months after joining the ARTI, I received a letter from Peradeniya University. The letter said, “The Dean of the Faculty of Arts wishes to see you on Saturday to discuss the timetable. You can start classes soon as a visiting lecturer.”

The ARTI Director was unhappy about the offer of a visiting lectureship and worried that I might leave ARTI to join the university. A few days later, the Registrar informed me that the Chairman had granted me permission to take up the visiting lectureship for three months, and such work must not interfere with my ARTI work.

Two months later, the university advertised two assistant lectureships in sociology. I applied for one without informing the ARTI. Although I was happy at the ARTI, I wanted to join the university because I thought teaching and researching was my vocation. Soon after the interview, the Dean of the Arts Faculty, whom I knew well, asked me to meet him in his office. He offered me a cup of tea and said, “Jayantha, you already have an excellent job at a premier research institute in Colombo. It offers much better prospects than an assistant lectureship in pursuing postgraduate studies abroad.” Then, he requested that I withdraw my application for the assistant lectureship before the second interview.

I told him my dream was to become a university professor one day, and I did not want to abandon that opportunity. He told me, “One of the candidates is from a remote village, and it would be difficult for him to find a job as you did. A university position is a good job for him. We can appoint him to one of the assistant lectureships if you withdraw your application. You are one of the chosen candidates.”

I was shocked and dispirited. I was unhappy, hurt, and confused. I did not know what to do. My ambition to become a lecturer and, finally, a professor at Peradeniya University seemed dashed against a rock. For a week, I was thinking about the second interview. I decided to get Mahinda’s advice. I visited him at the Ministry. He listened carefully and advised me to tell the ARTI Director about the offer and the issue raised by the Dean. He did not ask why I had applied without informing the ARTI.

The following morning, in the Chairman’s room, the ARTI Director asked me in front of Mahinda, “What do you think about the offer?” I told him about the Dean’s request. He asked me, “Are you interested in the university position. I said, “Yes.” Mahinda intervened and told me, “Jayantha, I respect your judgment. You should decide, not me or the Director. But I want to tell you one thing. Many people think getting a professorship at the university is like attaining nirvana. But that is a myth. I know many professors who are unhappy and trapped in the system. Please stay with us and get your postgraduate degrees as early as possible. As a young man, you have many opportunities ahead of you in life. You can decide to join a university in Sri Lanka or abroad later. Your postgraduate qualifications, research experience, and publications will place you in good stead to become a professor. But the decision is yours. You take time to decide. Please tell the Director your decision by the end of this week.”

I considered my options: to pursue an academic path at the university or to stay at the ARTI and become a development practitioner. The first would take me to Kandy, and the other would allow me to stay in Colombo. At the university, scholarships for higher studies were not guaranteed. After two years at the ARTI, I would become eligible for postgraduate studies abroad.

Going against the Dean’s advice and joining the university could harm me in the long run. Especially in the allocation of scholarships, the Dean had significant power. He might not recommend me for a scholarship because I had not listened to him. I was scared he might convince the second interview panel to select the candidate he supported and not offer me the lectureship. On the other hand, the ARTI had chosen me for a research and training officer post, and Mahinda had allowed me to teach at Peradeniya University as a visiting lecturer. His treatment of a ‘chit’ from the local political agent showed his liberal views and compassion towards young graduates who worried about political manipulations that could harm them.

I discussed my predicament with my mother and granduncle. Both said I should stay at the ARTI. My mother said I could travel to work from home and she could give me a tasty lunch parcel every day. My granduncle said I should remain in Colombo as I should soon start looking for a bride. He thought finding a suitable marriage partner in Colombo was much easier than in Kandy.

I told the Director I had decided to stay at the ARTI and did not attend the second interview. Later, I heard that the interview panel was prepared to postpone the second interview so that I could attend it on another day. I informed the Dean that I had decided to stay at the ARTI and asked him to approve my visiting lectureship. He agreed.

I wondered why the Dean discouraged me from coming for the second interview. He probably believed that ARTI was a better place for my career than the university, and he was genuinely worried about his candidate’s future. Many years later, a university colleague told me that the Dean supported the other candidate because both belonged to the same caste and from the same region. Anyway, I correctly decided not to join the university.

Mahinda frequently visited the ARTI to discuss their research programmes and field findings with the staff. He was a great storyteller. He cracked a joke or two before narrating a story. He mesmerized listeners with his stories. After a training programme in Tambuttegama, we had lunch at a farmer’s house. Mahinda noticed several young women who were busy serving visitors. Mahinda wanted to know whether I had selected the village for my fieldwork because of the girls. I told him, “Not necessarily.” He laughed and told me his guess was, at least, partially correct!

He told me about his humble beginnings. The Durham scholarship he had won enabled him to study in Colombo and enter the University of Ceylon. He completed his BA Honors degree in English under Professor Ludowyk. Mahinda planned to earn a living as an English teacher in Galle. But his friends and relatives encouraged him to sit the Ceylon Civil Service examination. He was among the 12 candidates chosen to become civil servants in 1950.

In the mid-1950s, Mahinda was an assistant postmaster general. During SWRD Bandaranaike’s government, there was a series of labour union strikes. Interdiction of a minor servant by Mahinda for assaulting an officer triggered a strike at the Postal Department. Mahinda received a call from the Prime Minister’s Office to be present at the Cabinet Secretariat. He thought the Prime Minister might ask him to resign as a part of the political solution to the strike. He got ready to go home and start English classes for local children.

peon led him to the Cabinet room. Bandaranaike asked Mahinda why he had interdicted the minor employee. Mahinda explained that the minor employee had an argument with an officer, lost his temper, and squeezed the officer’s testicles. Bandaranaike laughed aloud and asked Mahinda, “Is it a crime if a man squeezes another man’s balls?” Bandaranaike advised Mahinda to use administrative regulations sparingly. Mahinda left the Cabinet Office and waited until the Post Mater General came out of the Cabinet Office. He came out with the Minister. They started laughing when they saw Mahinda. The Minister told Mahinda to reinstate the minor servant if the trade unions were willing to call off the strike. Mahinda successfully ended the strike.

The day I left for the UK for postgraduate studies at the Institute of Development Studies (IDS), University of Sussex, the Director invited me to his residence for dinner, and Mahinda joined us. Mahinda told me it would be freezing cold in the UK, and I should have long johns (thermal men’s underwear). He gifted me two new pairs of long johns. While sipping a glass of arrack with soda, he told me I had done well as a researcher at the ARTI. He was happy that I had stayed with the ARTI. He said, laughing, that he would look for a suitable bride when I returned from England.

I met Mahinda at the IDS. He was on an official visit. He told me that my supervisor had suggested I be allowed to do a PhD and that he could find funds for me. Mahinda agreed to extend my leave of absence so that I could complete the PhD.

After retirement, Mahinda converted his garage at home in Ratmalana into a bedsitter with a narrow bed, a writing table, and a cupboard. Its roof was asbestos sheets, and the room had no ceiling fan. He had all the volumes of Prof Joseph Needham’s ‘Science and Civilisation in China’ on the shelf. Once, I saw him underlining passages in a volume and writing notes in an exercise book. When I asked him why he was reading Needham, he said we could learn much from China.

1984, I asked him to be my referee as I applied for a USA fellowship. He wrote a long reference letter in which he clearly stated his views on the role of social researchers in Sri Lanka: “I do not believe that a social scientist working in a developing country like Sri Lanka can afford to view problems solely through the mirror of his books. His conceptual and methodological training must always be matched by a thorough familiarity with the grinding realities in the field. Jayantha has learned this lesson only too well during his long tenure with the ARTI.”

(Last Sunday’s article on “Weere, the blind scholar at Peradeniya” was written by the writer of this article, Jayantha Perera. We apologise for his byline being inadvertently omitted. Editor)



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‘A remarkable time capsule’: The enchanting history of Oxford University’s 750-year-old medieval library

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Predating the Aztec Empire, Merton College Library in Oxford has been used by everyone from celebrated 14th-Century mathematicians to JRR Tolkien. In an exclusive interview with the BBC for its 750th birthday, its librarian describes what makes it so special.

At Merton College in Oxford, there is an antique chest. In the Middle Ages, three key-holders had to be summoned to reveal the riches within. But this treasure wasn’t gold or jewels. It was books.

Such strict security may sound overly cautious for mere parchment. But in an era before the printing press, books were a valuable commodity. They could take months to produce, as the entire text had to be painstakingly written out by hand. So, just as universities solicit cash from their alumni today, Merton College insisted its 13th-Century fellows donated books.

“There’s no single definition of a library” – Prof Teresa Webber

The Archbishop of Canterbury issued a decree in 1276 introducing this requirement, which marked the beginning of the library at Merton College. It has been running continuously ever since. To put that length of time in context, Merton’s library predates the Aztec Empire. Its unbroken history stretches from before the Black Death to beyond the Covid-19 pandemic. And its users have encompassed everyone from famous 14th Century mathematicians to Lord of the Rings author JRR Tolkien.

This month marks the library’s 750th anniversary. It’s a major milestone. But Merton’s extraordinary lifespan has been recognised since the Victoria era, when it was routinely described as the oldest library in England.

In the 20th Century, writers like Rudyard Kipling and John Buchan referenced it in works of historical fiction, bolstering its reputation as a particularly venerable library. As the cultural recognition of “the famous Merton Library” grew, claims about its longevity became exaggerated. Some overzealous Oxonians even declared it the oldest library in the world.

The origins of the historic library

Historians today are more careful about making such bold declarations. “It’s a complicated question,” says Prof Teresa Webber from the University of Cambridge. “There’s no single definition of a library. And there were all sorts of stages in the development of what we think of today as a library.”

Courtesy of the Warden and Fellows of Merton College Oxford Dr Julia Walworth is Merton College's librarian (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)
Dr Julia Walworth is Merton College’s librarian (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)

 

The origins of the library at Merton are certainly different from how we think of such institutions now. There was no librarian and there were no shelves for browsing. “There was a system of loaning and returning books from the chest,” Merton’s librarian, Dr Julia Walworth tells the BBC. “It would have been a formal thing. Rather than just saying, ‘Oh, go rummage and find the books you need,’ the whole community would come together to open the chest.”

“Horizontal shelves were installed for placing books upright. Merton is the first recorded use in Britain of this method of storing books” – Dr Julia Walworth

Merton’s collection started evolving into a modern library quite quickly. Just a few years after the Archbishop’s decree, several books were stored outside the chest for the first time. They were chained to a table in the college, making them available at any time. According to Walworth, this innovation “anticipates the modern distinction between loan and reference library collections”.

Merton’s book treasury moved closer to becoming a modern library in the 1370s, when a purpose-built room was constructed to house the growing collection. It was here that Merton introduced a vital improvement in book storage. “Horizontal shelves were installed for placing books upright,” Walworth says. “Merton is the first recorded use in Britain of this method of storing books.”

Curiously, Merton’s books were shelved with their spines inwards and their titles inked on the paper facing out. This was due to the continued use of chains, which were clipped on the fore-edge of each book’s cover. “The fellows were aware that chained books had a better chance of survival than books that went out on loan,” Walworth explains.

Courtesy of the Warden and Fellows of Merton College Oxford The historic library is the university's oldest – one of the oldest functioning academic libraries in Europe (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)
The historic library is the university’s oldest – one of the oldest functioning academic libraries in Europe (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)

 

Today, just a few volumes in the library are chained – purely for display purposes. And the remaining books are now placed in the modern fashion with their spines out. But otherwise, the medieval room remains a remarkable time capsule of the library’s history. Near the entrance, visitors can even see the 13th-Century chest, which Walworth believes is the original. During term time, the historic library room is still used by students. And this ongoing use is a major factor in the superlatives that are often applied to the age of Merton’s library. “It’s hard to think of an earlier library room that’s been in continuous use,” Webber says.

Claims about Merton’s longevity first gained traction in the Victorian era, as it became more of a tourist destination. Visitors would marvel at its stained-glass windows, as well as rare books like its 15th-Century edition of The Canterbury Tales. “It’s one of the earliest books printed in England,” Walworth explains. “What’s unique about Merton’s copy is the hand-illuminated borders.” Among those who visited the library was American writer Ralph Waldo Emerson, who mentioned it in his 1856 travelogue English Traits. In 1884, a young Beatrix Potter visited, describing the library’s “beautiful oak roof” and “ancient, dusty smell” in her diary.

By this time, books and magazines were increasingly describing the library in record-breaking terms. An 1878 guide to Oxford called Merton’s library “the most ancient now in England”. The 1885 edition of the Encyclopaedia Britannica described it as “the oldest existing library in England”. Gradually, these claims were inflated. A 1928 article in The Times recounted an event held by the Oxford Preservation Trust in which it was declared “the oldest library in the world”.

Courtesy of the Warden and Fellows of Merton College Oxford The library contains rare, medieval manuscripts – including a 15th-Century edition of The Canterbury Tales (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)
The library contains rare, medieval manuscripts – including a 15th-Century edition of The Canterbury Tales (Credit: Courtesy of the Warden and Fellows of Merton College Oxford)

 

This growing perception of Merton’s longevity was even referenced in F Scott Fitzgerald’s classic novel The Great Gatsby. In the book, the multi-millionaire title character fills his mansion with imitations of history’s most prestigious rooms. So, it’s only natural that his books live in a recreation he refers to as “the Merton College Library”. As Walworth puts it, “Merton’s library had become a byword for the ‘best’ ancient library” by that time. She even points out that Fitzgerald’s fictional scenario had roots in reality. “The dining clubs at Princeton University have historical imitation rooms. One of them is based on the Merton College Library.”

But today, Walworth rebukes any suggestion that Merton’s library is the world’s oldest. She prefers to describe it with several qualifiers, calling it “one of the oldest still-functioning academic libraries in Europe”. That more measured description recognises that not all historic libraries can be categorised in the same bucket – monastic libraries functioned very differently from private subscription libraries, for instance. But it also acknowledges ancient institutions around the globe. “It’s not that people weren’t aware of other parts of the world in the past,” Walworth says. “But there was a tendency for people to think of their own world as having primacy. Our outlook tends to be more global now, quite rightly.”

The debate over the world’s oldest library

Among these global institutions, there are several candidates for the contested title of world’s oldest library. When the Al-Qarawiyyin library in Morocco underwent a major restoration in 2016, it was described by several media outlets as “the oldest library in the world”. But Guinness World Records cites Saint Catherine’s Monastery in Egypt as the oldest continuously operating library.

Alamy Guinness World Records cites Saint Catherine's Monastery in Egypt as the world's oldest continuously operating library (Credit: Alamy)
Guinness World Records cites Saint Catherine’s Monastery in Egypt as the world’s oldest continuously operating library (BBC)

 

In both cases, it’s difficult to establish an exact starting date. For the Al-Qarawiyyin library, some scholars have cast doubt on the library’s claims of Ninth-Century origins, saying the “story has much myth about it”. In the case of Saint Catherine’s Monastery, the building was constructed in the Sixth Century. But ancient writings suggest that the library’s collections could date from two centuries earlier. “It depends how you count it,” Walworth says. “When are you going to start the timeline? What is the beginning of a library?”

However, Prof Richard Gameson from Durham University tells the BBC that the library at Saint Catherine’s Monastery “is probably the one with the longest continuous history”. But he caveats this by adding that “the nature of the ‘library’, how it was used and how it was understood changed over time”. So, any claim to be “the oldest” needs to be accompanied by an appropriate explanation of what a library is. Finding a single definition that allows for one conclusive record-holder seems a near-impossible task.

“You can think of the oldest library as the oldest coherent collection of books that stayed together,” says Webber. “Or you can think of it in terms of the survival of the physical space. Or you could ask, ‘What’s the oldest space and collection of books which has been there continuously?'”

She offers the Dunhuang Library Cave in China as an example. This secret chamber was filled with manuscripts and sealed sometime around the 11th Century. It was only opened again after its rediscovery in 1900. “But the books were still in continuous storage there,” Webber says.

Alamy The secret chamber in the Dunhuang Library Cave in China was filled with manuscripts and sealed around the 11th Century (Credit: Alamy)
The secret chamber in the Dunhuang Library Cave in China was filled with manuscripts and sealed around the 11th Century (BBC)

 

Finding a common definition of a library will only become more challenging now, as digital institutions offer physical spaces that do not even contain any books.  “The definition of what a library is has always needed to be a capacious one,” says Webber. “The introduction of new technology is simply a continuation of that. But I don’t think the library as a physical space will disappear.”

Walworth is similarly optimistic, as she embarks on a project to digitise Merton’s manuscripts. “People will be able to access them anywhere. But I think they will still want to come and see the library and understand how people used books in the past.”

Reflecting on the 750-year span of Merton’s library, this digital phase seems like just another step in a long evolution. Just as the books moved from the Archbishop’s chest to chained desks to horizontal shelves, now they will enter the virtual realm. “I suppose that’s why I now find it less useful to talk about libraries as ‘the oldest’,” Walworth says. “For me, the story is not about how long a library has been running. It’s more about the sense of community.”

She points out that the tradition of donating books introduced by the Archbishop of Canterbury in 1276 persists to this day. “What started when he laid down those injunctions was the idea of a common collection built by the people. So, it’s just remarkable that for 750 years people have maintained this connection with an institution and its books.”

Perhaps that proves that books really are the most durable treasure – whether they are handwritten on parchment and sealed in an antique chest or distributed as pixels in the cybernetic ether.

[BBC]

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Discovery of molecular structure of primary genetic material of life

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World DNA Day falls on 25 April:

On 25 April 1953, Watson and Crick published an article, in the acclaimed journal “Nature” titled “Molecular structure of nucleic acids: A structure for deoxyribonucleic acid”.

The one-page article largely based on theoretical arguments and the previous work of Rosalind Franklin who examined DNA using X-rays, changed the world forever by explaining how genetic information is copied and transmitted.

Everyone concerned with promoting science in the country should be aware of the story behind the discovery of DNA and tell it to their children and students and remind the policymakers.

The world commemorates the transformative event on 25th April every year. An example vividly illustrates how intense curiosity and imagination, rather than mere indulgence in technologies, leads to groundbreaking discoveries.

DNA Day is also intended to celebrate the completion of the Human Genome Project in 2003. Genome means the entire set of genetic information characterising an organism.

Heredity and inheritance

Heredity is the cause of transferring traits from parents to their offspring. The closely related word “inheritance “refers to the specific nature of the transmitted trait. For example, we say intelligence is hereditary in their family and he inherited his father’s intelligence.

The resemblance of progeny to parentage was common knowledge, taken for granted and considered a blending of maternal and paternal traits. Philosophers of antiquity proposed several theories to explain the inheritance of parental traits by the offspring. Hippocrates believed the essence of all body parts of the parents are incorporated into the male and female germinal essence and therefore the offspring display characteristics as a proportionate blend. Aristotle offered a different explanation. He argued that the active principle is in the male seminal fluid and the mother’s blood provided the original body material. The inaccuracy of these theories was apparent. Sometimes children possess qualities akin to grandparents rather than parents. Fathers or mothers of humans and animals, deformed by accidents or disease, gave birth to normal children- a clear proof that the acquired characters are not inherited. Children of a blue-eyed mother and a brown-eyed father have either blue or brown eyes but not a blend of blue and brown.

Two golden sayings in our culture, “Arae gathi nare” and “Jammeta wada lokuei purrudha” (“Hereditary characters persist” and “Habits overtake heredity “), agree more with modern genetics, than the views of Hippocrates and Aristotle.

Gregor Mendal’s groundbreaking experiment

The Austrian mathematician cum botanist, Gregor Mendel was the first to conduct a systematic investigation to understand the cause of heredity. Being unconvinced of the traditional explanations, he carried out a series of experiments lasting eight years to determine how the traits (plant height, seed color, flower color etc.) of pea plants are transmitted from generation to generation. When Mendel cross pollinated tall and short plants, he found that the progeny was entirely tall. However, when first generation tall plants were allowed to self-pollinate, the missing short trait reappeared at a statistically significant probability of 25 percent. Mendel’s work provided an unequivocal proof that traits do not blend but exist as unique entities, manifested from generation to generation following a predictable mathematical pattern.

Mendel’s finding remained unrecognized for more than 30 years. His ideas were too far ahead of time and biologists were shy of mathematics. In the early 1900s several European botanists arrived at the same conclusion based on independent experiments. With the advancement of microscopy, a great deal of information about plant and animal cells was gathered. A key finding was the presence of colored bodies in the cell nucleus named chromosomes, seen separating during cell division, leading to the hypothesis that Mendel’s genetic units (genes) should be physical entities present in the chromosomes.

Chemists and biologists wondered what the genetic material in chromosomes made off. Is it a protein, carbohydrate or a lipid? Most biological materials are constituted of these substances.

Discovery of DNA

Great discoveries are made by unusual people. The Swiss Friedrich Miescher belonged to a clan of reputed physicians. Following family tradition, he qualified as a doctor but did not engage in profitable practice of medicine. He decided to do research to understand the foundations of life. In search for new biological substances, he experimented with pus deposited in bandages and extracted a substance rich in phosphates but very different from proteins. The new substance called “nuclein” was indeed DNA. Later, the German biochemist Albrecht Kossel following the Miescher’s work, showed that DNA contains four crucial compounds, adenine (A), cytosine (C), guanine (G) and thymine (T), known as nucleotide bases.

Avery – MacLeod – McCarthy Experiment

The flu pandemic of 1918 killed an estimated 50 million people worldwide due to the pneumonia that followed the viral infection. Pneumonia was caused by the virulent bacterium Streptococcus pneumoniae. The British bacteriologist, Frederick Griffith attempting to find a vaccine for pneumonia, worked with two strains of Streptococcus pneumoniae, one virulent causing pneumonia in mice, and the other avirulent to them. He found that neither the virulent strain denatured by heating nor the live avirulent strain injected into mice caused the disease, whereas a mixture of the denatured virulent strain and the live avirulent strain was deadly to mice just as the virulent one. He concluded that some chemical compound present in the virulent strain – a transforming principle – has changed the avirulent strain to the virulent strain.

In 1944, Oswald Avery, Colin MacLeod and Maclyn McCarty working at the Rockefeller University, United States, continued the work of Frederick Griffith to identify the transferring principle and found that it is not protein as widely believed, but deoxyribonucleic acid (DNA). Their result pointed to the conclusion that DNA is the carrier of genetic information.

A book by a physicist that triggered a transformation in biology

The insights of brilliant brains engaged in fundamental inquiry have opened the way for major scientific discoveries and technological innovations. In 1944, the Austrian theoretical physicist Erwin Schrodinger, one of the founders of quantum mechanics, published a book titled “What is life? The physical aspect of the living cell “. The American biologist Maurice Wilkins said he was so inspired by Schrodinger’s book and after reading it, he decided to switch from ornithology to genetics. While physicist Maurice was influenced to take up biology. Francis Crick was a physicist working on magnetic mines for the British Admiralty during the war. After reading “What is life” he thought a physicist could find treasures in biology and joined the Cavendish Laboratory in Cambridge to pursue a Ph.D.

Structure of the DNA molecule

When DNA was shown to be the molecular entity that encodes genetic information, chemists rushed to determine its structure.

The pattern formed when X-rays passing through a material cast an image on a screen, provides information about its molecular structure. In 1938, the English physicist William Astbury examined DNA using x-rays and concluded that the molecule has a helical structure. Having heard a group in the United Kingdom was attempting to unearth the structure of DNA, the American theoretical chemist, Linus Pauling, adopted Astbury’s data and proposed a model for the structure of DNA, publishing the results in the journal “Nature” in January 1953.

There was an obscure but remarkably talented person, Rosalind Franklin, pursuing x-ray diffraction studies on DNA at King’s College London. After a painstaking effort, she obtained accurate x-ray diffraction images of DNA. Her colleague, Maurice Wilkins, working in the same laboratory, passed the images to Francis Crick and James Watson at Cavendish Laboratory.

Crick and Watson were more insightful and theoretical in their approach to elucidating the structure of DNA. They, inspired by Erwin Schrodinger’s hypothesis, that the entity accounting for heredity should be an aperiodic molecular entity in cells, arrived at the double helix model, showing that Linus Pauling’s model was erroneous. The Crick – Watson model explained how DNA stores information and replicates during cell division. Their assertions were subsequently confirmed rigorously by experimentation. Crick, Watson and Wilkins received the Nobel Prize for Physiology and Medicine in 1962.

The work following the Crick – Watson model, firmly established that the DNA is a polymer string constituted of two strands made of a sugar- phosphate backbone, connected to each other by linkage nucleotide bases A, T, G, C. The base A links base T and G to C. When one strand is defined by the arrangement of bases, the complementary strand is defined. The arrangement bases store information analogously to a four-letter alphabet. Each individual in a species has a unique sequence of arrangement base pairs. The variation within the species is generally a fraction of a percent.

The Watson-Crick model also explained how the DNA molecule replicates. The two strands unwind and separate, and two complementary strands are inserted. The detailed dynamics of the replication process are not fully understood.

‘DNA is a cookbook’

DNA functions like a multiple – volume cookbook, written in a four-letter alphabet. The volumes are kept in a rack in the kitchen. The rack is the nucleus and volumes on it are the chromosomes, and the cell is the kitchen. A paragraph giving a recipe is a gene. Enzymes act as chefs, who read recipes and give instructions to cell machinery to prepare the dishes, which are proteins. The system is so complex; a complete macroscopic analogy would be impossible.

The significance of the Crick- Watson work

Until Charles Darwin proposed the idea of evolution, biology lacked a theoretical foundation. Darwin hypothesized, when organisms reproduce, the progeny inherit parental characters, but there are variations. The variants, though similar to the parents, have some new or altered characters. If these characters, originating from mutations or cross – breeding are favorable for survival in the environment, they dominate in the population, inheriting advantageous traits. Thus, random generation – to – generation, advancements of living organisms, become possible – a way of improving the design of things in a production process without a designer. Living systems store information and progeny retrieve them, when required. A bird hatched from an egg when matured, knows how to fly.

The discovery of DNA and understanding how it stores genetic information, replicates and mutates explained Darwinian evolution. A mutation is a change in the ordering of base pairs, accidentally during replication or due to external chemical or physical causes. In sexual reproduction, the offspring gets nearly half of its DNA from each parent. Consequently, the offspring does not have DNA identical to one parent. It mixes up DNA in the species. However, mutations generate new genes, driving evolution. Sexual reproduction and mutation acting in concert introduced the diversity of life on earth we see today.

Once science becomes explanatory and predictive, it opens the way for innovations. Theories of mechanics and electromagnetism formulated in the late 19th and early 20th centuries brought forth modern engineering, transforming it from an empirical craft to a scientific technological discipline. Before the discovery of DNA structure and its function, biological innovations were largely empirical. Today we have genetic engineering – genes in organisms can be manipulated. The goal of more advanced genetic engineering, referred to as synthetic biology, aims to induce major genetic changes to organisms by incorporating several genes to alter biochemical, physiological and anatomical functions. Gene technology is rapidly transforming medicine, agriculture and biotechnology. Cures have been found for diseases formerly branded incurable.

How did DNA come into existence

Life is believed to have originated in prebiotic oceans enriched with carbon and nitrogenous substances. How did DNA originate there? Today, chemists can synthesize DNA in minutes, via selective procedures, only humans can do with their knowledge. Even in a vast ocean containing trillions of times more molecular ingredients than in a test tube, a molecule as complex as DNA is most unlikely to be created by random events during the largest possible time scales of the universe. A plausible scenario would be DNA evolving from simpler self-replicating molecules such as RNA (a single strand of DNA) precursors. Unlike RNA, DNA is highly stable and good stability is necessary for the evolution of advanced forms of life.

Epigenetics

Earlier we pointed out there are two golden sayings in our culture: “Arae gathi nare” and “Jammeta wada lokuei purudha (“Hereditary characters persist” and “Habits overtake heredity “). The first is a consequence of our genetic predisposition determined by DNA and explicit genes. However, the character of an individual is also influenced by the physical, social and cultural environment. Although completely non-genetic, our children frequently follow habits we indulge in. Again, the behavior of an individual is also influenced by the physical, social and cultural environment.

The environmental factors also trigger or silence genes. The study of this important genetic effect, which does not alter the sequence of base pairs, is referred to as epigenetics. Epigenetic effects could be deleterious or beneficial. Sometimes, chronic stress causes disease, including cancer. Research suggests engagement in creative and imaginative activities, and establishes favorable epigenetic changes in the brain. Inheritance is dictated mainly by the arrangement of base pairs in DNA. Epigenetic changes involve chemical changes in DNA without altering the sequence. These alterations are erasable but allow transmission to subsequent generations.

Conclusion: World DNA day message to lawmakers

The discovery of the structure of DNA stands as one of the most significant scientific discoveries in human history. It is a lesson to all those involved in research and education, telling how great discoveries originated. It is intense curiosity, imagination and preparation rather than mere indulgence in technologies that clear the path for discovery and innovation. A society that advocates policies conducive to discoveries, also develops new technologies that follow. If we just borrow technologies from places where they originated, hoping for quick economic returns, the effort would be a gross failure. Students, determined to be the best judging from exam performance, engage in professional disciplines and perform exceptionally. Why are we short of discoveries and innovations in those disciplines? Will our lawmakers ever realize the issue? They need to wonder why we are weak in science and poor in innovation. Right policies can even reverse adverse epigenetic attributes propagating in a society!

By Prof. Kirthi Tennakone
ktenna@yahoo.co.uk
National Institute of Fundamental Studies

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Features

Death of the Sperm Whale

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REVIEWED BY Prof. Rajiva Wijesinha

Earlier this year, I sent her most recent book by an old friend, Kamala Wijeratne. Death of the Sperm Whale is her first book of poetry in four years, though in between she has published fiction, two books though both of them too were slim volumes. I am full of admiration for her in that she keeps going, the last of the poets whom I helped to a wider readership in the eighties, when I championed Sri Lankan writing in English, something hardly any academic was prepared to do in those conservative days.

Kamala Wijeratne

Kamala’s subjects are those she has explored in the past, but the use of the plural indicates that her range is expansive. She dwells much on nature, but she deals also with political issues, and engages in social criticism. There are several poems about Gaza, the multiple horrors occurring there having clearly affected her deeply. She repeatedly draws attention to the slaughter of children, the infants sent by God only to be taken back. And she deals with the destruction of the life of a doctor, after his healing, a theme that has kept recurring in the ghastly world which is subject to the whims of the incredibly nasty Netanyahu.

The title poem is about a whale destroyed by ingesting plastic, a tragedy to which we all contribute, though those who ‘loll on the beach, their senses dulled by the burgers they eat’ could not care less. More immediate is the simple account of a friend whose infant had died in hospital, when they diagnosed pneumonia too late.

Contrasting with these urgent statements are Kamala’s gentle perceptions, as when she writes of her son supporting her as she walks, while she thinks back to the days she supported him; of a marigold growing in a crack in a shrine, offering obeisance with its golden flowers to the Noble One; of birds investigating her dining room and deciding not to build there, the male lingering ‘confused and irritated’ but eventually following the female through the window for ‘She was mistress after all.’

She is deeply interested in the passing of time, and its impact on our perceptions. The first poem in the book is called ‘First Poem of 2024’ when she ‘heard the weeping of the dying year’, and went on to meditate on how we have categorised the passing of time, while the universe moves on regardless.

She welcomes the return of the Avichchiya, the Indian Pitta, a bird that has figured previously in her poetry, after six months, but this time she spares a thought for his case against the peacock, which stole his plumes.

There are two personal poems, one about a former student who turned her back on her when she had achieved success, the other about being nominated for a literary award, but not getting it after the excitement of attending the Awards Ceremony. Swallowing her disappointment, she congratulates the winner, noting that she will not go into ecstasies the next time she is nominated.

Paraphrase cannot do justice to Kamala Wijeratne’s gentle touch, which has expanded its reach over the years. So,A I will end by quoting from her tribute to Punyakante Wijenaike, another of the distinguished ladies whose work I promoted, the one before the last to leave us. The tribute ends, recalling her most impressive work Giraya,

Like the nutcracker
That makes a clean cut
You cut the human psyche
To reveal its darkest depths

by Kamala Wijeratne

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