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Battling a rare brain-eating disease in an Indian state

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This single-celled brain-eating amoeba can enter the nose during swimming [BBC]

On the eve of Onam, the most joyous festival in India’s Kerala state, 45-year-old Sobhana lay shivering in the back of an ambulance, drifting into unconsciousness as her family rushed her to a medical college hospital.

Just days earlier, the Dalit (formerly known as untouchables) woman, who earned her living bottling fruit juices in a village in Malappuram district, had complained of nothing more alarming than dizziness and high blood pressure. Doctors prescribed pills and sent her home. But her condition spiralled with terrifying speed: uneasiness gave way to fever, fever to violent shivers, and on 5 September – the main day of the festival – Sobhana was dead.

The culprit was Naegleria fowleri – commonly known as the brain-eating amoeba – an infection usually contracted through the nose in freshwater and so rare that most doctors never encounter a case in their entire careers. “We were powerless to stop it. We learnt about the disease only after Sobhana’s death,” says Ajitha Kathiradath, a cousin of the victim and a prominent social worker.

In Kerala this year, more than 70 people have been diagnosed and 19 have died from the brain-eating amoeba. Patients have ranged from a three-month-old to a 92-year-old man.

Normally feeding on bacteria in warm freshwater, this single-cell organism causes a near-fatal brain infection, known as primary amoebic meningoencephalitis (PAM). It enters through the nose during swimming and rapidly destroys brain tissue.

Kerala began detecting cases in 2016, just one or two a year, and until recently nearly all were fatal. A new study has found only 488 cases have been reported globally since 1962 – mostly in the US, Pakistan and Australia. And 95% of the victims have died from the disease.

Universal Images Group via Getty Images Naegleria fowleri is an amoeba (one-celled living organism) that lives in soil and warm freshwater, such as lakes, rivers, and hot springs. It is commonly called the brain-eating amoeba because it can cause brain infection when water containing the amoeba rises in the nose. Only about three people in the United States are infected each year, but these infections are usually fatal. (Photo by: CDC/IMAGE POINT FR/BSIP/Universal Images Group via Getty Images)
Naegleria fowleri, or the brain-eating amoeba, lives in lakes, rivers and hot springs [BBC]

But in Kerala, survival appears to be improving: last year there were 39 cases with a 23% fatality rate and this year, nearly 70 cases have been reported with about 24.5% mortality. Doctors say the rise in numbers reflects better detection, thanks to state-of-the-art labs.

“Cases are rising but deaths are falling. Aggressive testing and early diagnosis have improved survival – a strategy unique to Kerala,” said Aravind Reghukumar, head of infectious diseases at the Medical College and Hospital in Thiruvananthapuram, the state’s capital. Early detection allows customised treatment: a drug cocktail of antimicrobials and steroids targeting the amoeba can save lives.

Scientists have identified around 400 species of free-living amoebae, but only six are known to cause disease in humans – including Naegleria fowleri and Acanthamoeba, both of which can infect the brain. In Kerala, public health laboratories can now detect the five major pathogenic types, officials say.

The southern state’s heavy reliance on groundwater and natural water bodies makes it particularly vulnerable, especially as many ponds and wells are polluted. A small cluster of cases last year, for example, was linked to young men vaping boiled cannabis mixed with pond water – a risky practice that underscores how contaminated water can become a conduit for infection.

Kerala has nearly 5.5 million wells and 55,000 ponds – and millions draw their daily water from wells alone. That sheer ubiquity makes it impossible to treat wells or ponds as simple “risk factors” – they are the backbone of life in the state.

“Some infections have occurred in people bathing in ponds, others from swimming pools, and even through nasal rinsing with water which is a religious ritual. Whether in a polluted pond or a well, the risk is real,” says Anish TS, a leading epidemiologist.

Nebula NP This pond is located in Sobhana’s village in Malappuram district. The health department’s notice says swimming and bathing in the pond are prohibited until further notice. A warning sign board, preventing people from entering the pond, placed in front of Pathiriyal Valiya Pond in Thiruvali grama panchayat in Malappuram district following the death of a woman due to Amoebic Meningoencephalitis.
A warning sign at a Kerala pond prohibiting swimming after a woman’s death from amoebic meningoencephalitis [BBC]

So public health authorities have tried to respond at scale: in a single campaign at the end of August, 2.7 million wells were chlorinated.

Local governments have put up sign boards around ponds warning against bathing or swimming and evoked the Public Health Act to enforce regular chlorination of swimming pools and water tanks. But even with such measures, ponds cannot realistically be chlorinated – fish would die – and policing every village water source in a state of more than 30 million people is unworkable.

Officials now stress awareness over prohibition: households are urged to clean tanks and pools, use clean warm water for nasal ablutions, keep children away from garden sprinklers and avoid unsafe ponds. Swimmers are advised to protect their noses by keeping their heads above water, using nose plugs and avoiding stirring up sediment in stagnant or untreated freshwater.

Yet, striking a balance between educating the public about real risks – of using untreated freshwater – and avoiding fear that could disrupt daily life is challenging. Many say despite guidelines issued for more than a year, enforcement remains patchy.

“This is a difficult problem. In some places [hot springs], signs are posted to warn of the possibility of the amoebae in the water source. This is not practical in most situations since the amoebae can be present in any source of untreated water [lakes, ponds, pools],” Dennis Kyle, a professor of infectious diseases and cellular biology at the University of Georgia, told the BBC.

“In more controlled environments, frequent monitoring for proper chlorination can significantly reduce chances of infection. These include pools, splash pads and other man-made recreational water activities,” he said.

Abhishek Chinnappa/Getty Images Boys use a makeshift raft to cross a canal in Kerala.
Kerala has nearly 5.5 million wells and 55,000 ponds [BBC]

Scientists warn climate change is amplifying the risk: warmer waters, longer summers and rising temperatures create ideal conditions for the amoeba. “Even a 1C rise can trigger its spread in Kerala’s tropical climate and water pollution fuels it further by feeding bacteria the amoeba consumes,” says Prof Anish.

Dr Kyle adds a note of caution, noting that some past cases may simply have gone unrecognised, with the amoeba not identified as the cause.

That uncertainty can make treatment even harder. Current drug cocktails are “sub-optimal,” Dr Kyle explains, adding that in rare survivors, the regimen becomes the standard. “We lack sufficient data to determine if all the drugs are actually helpful or needed.”

Kerala may be catching more patients and saving more lives, but the lesson reaches far beyond its borders. Climate change may be rewriting the map of disease – and even the rarest pathogens may not stay rare for long.

[BBC]



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Foreign News

Meta blocks 550,000 accounts under Australia’s social media ban

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Australia's landmark socual media ban for kids is being watched closely around the world (BBC)

About 550,000 accounts were blocked by Meta during the first days of Australia’s landmark social media ban for kids.

In December, a new law began requiring that the world’s most popular social media sites – including Instagram and Facebook – stop Australians aged under 16 from having accounts on their platforms.

The ban, which is being watched closely around the world, was justified by campaigners and the government as necessary to protect children from harmful content and algorithms.

Companies including Meta have said they agree more is needed to keep young people safe online. However they continue to argue for other measures, with some experts raising similar concerns.

“We call on the Australian government to engage with industry constructively to find a better way forward, such as incentivising all of industry to raise the standard in providing safe, privacy-preserving, age appropriate experiences online, instead of blanket bans,” Meta said in a blog update.

The company said it blocked 330,639 accounts on Instagram, 173,497 on Facebook, and 39,916 on Threads during it’s first week of compliance with the new law.

They again put the argument that age verification should happen at an app store level – something they suggested lowers the burden of compliance on both regulators and the apps themselves – and that exemptions for parental approval should be created.

“This is the only way to guarantee consistent, industry-wide protections for young people, no matter which apps they use, and to avoid the whack-a-mole effect of catching up with new apps that teens will migrate to in order to circumvent the social media ban law.”

Various governments, from the US state of Florida to the European Union, have been experimenting with limiting children’s use of social media. But, along with a higher age limit of 16, Australia is the first jurisdiction to deny an exemption for parental approval in a policy like this – making its laws the world’s strictest.

The policy is wildly popular with parents and envied by world leader, with the Tories this week pledging to follow suit if they win power at the next election, due before 2029.

However some experts have raised concerns that Australian kids can circumvent the ban with relative ease – either by tricking the technology that’s performing the age checks, or by finding other, potentially less safe, places on the net to gather.

And backed by some mental health advocates, many children have argued it robs young people of connection – particularly those from LGBTQ+, neurodivergent or rural communities – and will leave them less equipped to tackle the realities of life on the web.

(BBC)

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Bride and groom killed by gas explosion day after Pakistan wedding

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(Pic BBC)

A newly married couple were killed when a gas cylinder exploded at a house in Islamabad where they were sleeping after their wedding party, police have said.

A further six people – including wedding guests and family members – who were staying there also died in the blast. More than a dozen people were injured.

The explosion took place at 07:00 local time (02:00 GMT) on Sunday, causing the roof to collapse.

Parts of the walls were blown away, leaving piles of bricks, large concrete slabs and furniture strewn across the floor. Injured people were trapped under the rubble and had to be carried out on stretchers by rescue workers.

(BBC)

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Rescuers race to find dozens missing in deadly Philippines landfill collapse

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More than 30 people are thought to be missing following the landslide in Cebu [BBC]

Rescue workers are racing to find dozens of people still missing following a landslide at a landfill site in the central Philippines that occurred earlier this week, an official has said.

Mayor Nestor Archival said on Saturday that signs of life had been detected at the site in Cebu City, two days after the incident.

Four people have been confirmed dead so far, Archival said, while 12 others have been taken to hospital.

Conditions for emergency services working at the site were challenging, the mayor added, with unstable debris posing a hazard and crew waiting for better equipment to arrive.

The privately-owned Binaliw landfill collapsed on Thursday while 110 workers were on site, officials said.

Archival said in a Facebook post on Saturday morning: “Authorities confirmed the presence of detected signs of life in specific areas, requiring continued careful excavation and the deployment of a more advanced 50-ton crane.”

Relatives of those missing have been waiting anxiously for any news of their whereabouts. More than 30 people, all workers at the landfill, are thought to be missing.

“We are just hoping that we can get someone alive… We are racing against time, that’s why our deployment is 24/7,” Cebu City councillor Dave Tumulak, chairman of the city’s disaster council, told news agency AFP.

AFP via Getty Images A close up shot of a woman wiping a tear away from her eye at the scene of the landfill site, while a small boy looks across at her.
Relatives of the missing are waiting anxiously for any news of their loved ones [BBC]

Jerahmey Espinoza, whose husband is missing, told news agency Reuters at the site on Saturday: “They haven’t seen him or located him ever since the disaster happened. We’re still hopeful that he’s alive.”

The cause of the collapse remains unclear, but Cebu City councillor Joel Garganera previously said it was likely the result of poor waste management practices.

Operators had been cutting into the mountain, digging the soil out and then piling garbage to form another mountain of waste, Garganera told local newspaper The Freeman on Friday.

The Binaliw landfill covers an area of about 15 hectares (37 acres).

Landfills are common in major Philippine cities like Cebu, which is the trading centre and transportation gateway of the Visayas, the archipelago nation’s central islands.

A map showing the Philippines and the location of Cebu City

[BBC]

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