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Tracking the genetic passport of COVID-19

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Implications of different strands of Coronavirus

In late July, scientists claimed that there were six strands of the Coronavirus that caused COVID-19, then there was talk of eight. Sudden outbreaks in the US and Europe have caused speculation that deadlier, infectious strains of the virus may be circulating, with some early studies hinting at as many as 30 kinds of the virus. Coronavirus infections surpassed the 400,000 mark in the first six months alone, exemplifying its formidability as a fast mutating virus. Since the original outbreak in Wuhan, the Coronavirus has infected over 47,428,000 claiming over 1,213,000 lives. Over 11,000 cases have been reported locally with 23 fatalities. Could genetic sequencing better prepare health authorities to deal with the pandemic?

Sequencing could also help to identify which strands are more tenacious and which are dying out. In turn health authorities could use such information to learn how to mitigate the spread of COVID-19, and which medical interventions work best. This is where open-source projects such as NextStrain.org comes in. NextStrain uses genetic sequences of viruses collected from patients, contributed by health authorities from around the world, to track the evolution of epidemics in global maps and phylogenetic charts, the family trees for viruses.

According to Professor Benjamin Howden at the Doherty Institute, Australia, quoted in The Sydney Morning Herald, sequencing or tracking the virus’s ‘genetic passport’, in other words tracing from where a specific strand had been ‘imported’, has now revolutionised how health authorities fight pandemics, and will become critically important in countries that have recently eased out of lockdown. For example, in circumstances where clusters emerge with no clear source, looking for connections in the genetic code of the virus could make contact tracing much more efficient in a country like Sri Lanka where many have been repatriated from countries where COVID-19 is wreaking havoc.

According to health authorities the new strain of the virus, which originated in a new cluster in Minuwangoda, is far more virulent compared to the first wave between March and April. With the virus spreading fast, detected in practically all districts, several hundred patients are reported each day, according to Chief Epidemiologist Dr Sudath Samaraweera.

The latest mutation is unique in its ubiquity, leading to conflagrations in Europe, US and, now Asia. Laboratory experiments suggest that the new strain, officially designated D614G, and familiarly known among scientists as ‘G’, because it has lead to the genetic instruction for the amino acid glycine (G) to be altered, is more infectious and has a higher viral load, making people who have contracted this particular strain more likely to spread it. In fact, the new strain is thought to be as much as 10 times more infectious. The ‘G’ strain, which first appeared in January, is found in the dominant variant of the coronavirus, while the ‘L’ strain that originated in Wuhan is gradually disappearing. The ‘G’ strain, associated with outbreaks in Europe and US, is believed to have originated in Germany, according to NextStrain cofounder Trevor Bedford, a computational biologist at the Fred Hutchinson Cancer Research Center in Seattle, quoted in National Geographic. But nothing is definitive when it comes to the Coronavirus, warns Bedford. Researchers are forced to strike a high-stakes balance between disseminating information quickly and assuring their accuracy.

Scripps Research virologist, Hyeryun Choe, quoted in The Washington Post article titled, ‘This Coronavirus mutation has taken over the world. Scientists are trying to understand why’, points out that, fortunately the ‘G’ strain does not make patients any sicker, despite its higher viral load and any vaccine based on the original strain would be just as effective on the new strain.

Researchers claim that different types or variants of COVID-19 maybe distinguished by a unique set of symptoms. Most pronounced symptoms of COVID-19 include fever, shortness of breath, fatigue, muscle aches, headaches and of course a persistent cough. But several symptoms were later included in diagnostics, as they were increasingly reported by COVID-19 positive patients, such as a loss of sense of taste and smell, the medical terms of which are ageusia and anosmia, respectively. A study by the UK’s King’s College London has grouped these into six ‘symptom clusters’, with a spectrum of breathing difficulties.

1. Flu-like with no fever:

Headache, loss of smell, muscle pains, cough, sore throat, chest pain, no fever.

2. Flu-like with fever:

Headache, loss of smell, cough, sore throat, hoarseness, fever, loss of appetite.

3. Gastrointestinal:

Headache, loss of smell, loss of appetite, diarrhoea, sore throat, chest pain, no cough.

4. Severe level one, fatigue:

Headache, loss of smell, cough, fever, hoarseness, chest pain, fatigue.

5. Severe level two, confusion:

Headache, loss of smell, loss of appetite, cough, fever, hoarseness, sore throat, chest pain, fatigue, confusion, muscle pain.

 

6. Severe level three, abdominal and respiratory: Headache, loss of smell, loss of appetite, cough, fever, hoarseness, sore throat, chest pain, fatigue, confusion, muscle pain, shortness of breath, diarrhoea, abdominal pain.

According to the King’s College research, quoted in the World Economic Forum article titled ‘COVID-19: Could your earliest symptoms predict how ill you’ll get?’, earliest symptoms might help predict how sick someone could become with the progress of the disease. According to the study 16 percent of group 1 patients were admitted to hospital, while almost half of those in group 6 were. Those of groups 4,5 and 6 were older patients with underlying health conditions ranging from diabetes to obesity.

 

As such, Charles Chiu, professor of medicine and infectious disease at the University of California, San Francisco School of Medicine, in USA Today article, ‘8 strains of the coronavirus are circling the globe. Here’s what clues they’re giving scientists’, says that it is unlikely that the different symptoms are related to people being infected with different strains of the virus.

In more positive news, the Coronavirus mutates at a fairly steady rate, approximately 20 mutations per year, according to Professor Francois Balloux, who heads the genetics institute at University College London, quoted in The Sydney Morning Herald. It is not as prolific as influenza, a virus that mutates at such an alarming rate that it requires an updated vaccine every season to keep up with all its mutations. Moreover, research has found that no one strain of the virus is more deadly than another.

Strains are also unlikely to grow more lethal as they evolve. In fact, Australian Government agency, Commonwealth Scientific and Industrial Research Organisation (CSIRO), dangerous pathogens lab, Professor Seshadri Vasan believes that, since a virus’s main objective is to spread and not kill off its hosts, over time the Coronavirus will become milder, the way past pandemic flu strains have, as they adapted to their new host. But it could become a recurring phenomenon, much like influenza, at least until vaccination programmes stamp it out. On the bright side, a virus that mutates comparatively slow is unlikely to change to evade a vaccine, opines scientists. (SP)



Features

The challenge of keeping value-based politics alive

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Anti-migrant protests in Durban, South Africa. BBC

The current outbreak of anti-immigrant protests in Durban, South Africa is bound to have taken many a subscriber to value-based politics or political idealism quite by surprise. After all, this is evidence that despite the historic accomplishments of nation-builders of the stature of the late President Nelson Mandela it cannot be taken for granted that identity politics, including racism in its worst forms, is no more in South Africa.

At the time of this writing details are scarce on the substantive root causes of the protests but it could very well be that economic grievances, particularly on the part of the majority community in South Africa, are contributing considerably to the disaffection. Shrinking employment and material prospects are likely to figure majorly among the factors igniting the unrest.

Fortunately, the local authorities in Durban are losing no time in calling for peaceful co-existence among the relevant communities and are pointing to the vital importance of stepping-up national integration processes. Apparently, immigrants in sizable numbers from neighbouring countries are present in Durban. However, international TV footage of the protests quoted some local authorities as saying that the majority of the immigrants in some centres that housed them were not illegal migrants and had the documents that entitle them to be in Durban.

In the Durban protests the world has fresh proof of the socially divisive consequences of the gathering globe-wide economic disaffection, touched off particularly by the continuing crisis in West Asia. Going ahead, the world would need to brace for increasing identity-based unrest of the kind it is just witnessing in South Africa.

Considering that the material lot of ordinary people everywhere could only aggravate progressively, with the US and Iran showing no signs of negotiating an end to their confrontation any time soon, it will be left to the more democratic and progressive sections of the world community to initiate positive measures collectively to bring a measure of relief to the discontented.

The swiftness with which such relief will be provided would depend crucially on the importance those sections taking up these undertakings attach to value-based politics as opposed to Realpolitik of power politics.

Going by these yardsticks, Italy could be considered to be moving in the right direction. Recently Italy came to the fore in initiating the collective named, ‘Rome Coalition for Food Security and Access to Fertilizer’, which has as one of its aims the swift provision of fertilizer to economically weak African countries.

In a recent statement Italian Minister of Foreign Affairs and International Cooperation, Antonio Tajani, said that a principal aim of the project was to ensure that the farmers of Africa gained easy access to fertilizer, considering that food security is a growing concern among some of Africa’s economically vulnerable countries.

The statement went on to mention that some 30 countries hailing from the Mediterranean region, the Middle East, the Balkans as well as the FAO had been invited to join the coalition. The venture is far-seeing in that food security is main among the reasons for social discontent which in turn could degenerate into endemic political turmoil and bloodshed. Separatist violence and geographical fragmentation of countries wouldn’t be too far behind these developments, as Africa itself has often proved.

It is hoped that more G7 countries would take the cue from Italy and do what they could to ease the hardships of economically distressed countries, particularly of the global South. In these efforts they would need to break rank with the US, which is today brutally indifferent to the consequences of its policy of making ‘America First’, come what may.

Going by current developments, the Trump administration seems to be blithely oblivious to the wider, deleterious effects of its policy course in West Asia. Besides rendering Iran militarily and otherwise impotent nothing else seems to matter to Washington, as regards West Asia. This is policy short-sightedness of an extreme kind. After all, right now West Asia could be said to be sitting on the proverbial powder keg.

On the other hand, Iran is not giving the world the impression that it is doing anything constructive to get out of the policy straitjacket that it wove for itself decades ago. Rather than enter into a policy of ‘live and let live’ in relation to Israel in particular and initiate a process of reconciliation with the latter, it has chosen to operate within policy parameters that continue to damn Israel. This has put Israel always on the ‘defensive’ so to speak and prevented the opening up of space for meaningful dialogue.

That said, Israel is obliged to explore the possibilities of entering into a negotiatory process with the Arab-Islamic world that could lead to a de-escalation of tensions and bloodshed. It cannot continue to look at its neighbours through lenses that distort them as archetypal enemies who should be ‘wiped off completely from the face of the earth.’

In other words, the need is urgent for Realpolitik to give way to value-based politicks. Italy is beginning to prove that the latter approach could be pursued with some success. May be the EU and the UK could throw their weight behind these initiatives as well and establish that international politics could be refashioned on the basis of humane, civilized norms. The UN would need to be fully supportive of these moves and prove an organizational nucleus of the operations that follow.

In fact the time is ripe for people of conscience to collectively stand up on the side of peace and say ‘No’ to war and violence. Organizations such as the ICRC, the WHO and Medicines Sans Frontiers have already taken up this call. Referring to the widespread destruction of health facilities and their dehumanizing results these organizations have said, among other things, that ‘This is not a failure of the law. It is a failure of political will.’

True, ‘failure of political will’ among those powers that matter accounts for the runaway, uncontrollable nature of war and destruction in contemporary times, but more fundamentally it is a failure of the human conscience. It could very well be that the phenomenal levels to which violence and war have been unleashed today have had the effect of deadening consciences. This is a matter for urgent study and wide discussion.

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Vesak celebrations … with Cuteefly

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Perfect for celebrations, gifts, and meaningful occasions // Gift pack

I would describe Indunil Kaushalya Dissanayaka as innovative and creative, and she operates under the name of Cuteefly.

Indunil always comes up with something novel to celebrate special occasions, and she does it with candles … and that’s her profession.

She was in the spotlight when she created a happening scene, with candles, for Christmas, Sinhala and Tamil New Year, and Valentine’s Day.

As lanterns light up Sri Lanka for Vesak, the Colombo-based candle maker is quietly turning wax and wick into little pieces of the festival.

Candles reflecting Vesak themes

Her candles reflect Vesak themes – light, peace, remembrance, giving, etc., to enable you to fill your Vesak celebration with devotion and beauty.

Among her Vesak creations is a lotus-shaped soy candle, scented with sandalwood, lavender, etc., meant to burn during this Vesak Poya Day.

Indunil Kaushalya Dissanayaka: Customers
praise her for her creativity

These handcrafted Vesak candles are perfect for offering at the temple, she says.

What makes her creations so novel is that they come in different shapes, scents, themes, and all are handmade.

What’s more, her customers have heaped praise on her for her creativity.

According to Indunil, her creations are perfect as a thoughtful gift … to bring beauty, unity, and light into every moment.

Says Indunil: “Our beautifully handcrafted Unity candles are designed with premium detail and love, making them perfect for celebrations, gifts, and meaningful occasions.”

Cuteefly, says Indunil, is available online.

Readers could contact Indunil on 0778506066 for more details.

He Facebook Page is: Cuteefly.

Handmade with love

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Features

Dark Spots …

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Yes, dark spots do crop up on the skin, especially with sun exposure and, of course, as the skin ages.

However, these tips should be of immense benefit to those who are faced with dark spots.

Lemon and Honey Glow Mask:

You will need 01 teaspoon lemon juice and 01 teaspoon honey.

Mix the lemon juice and honey well and then apply this mixture, only on the dark spots.

Leave for 10–15 minutes and then rinse with cool water.

Benefits:

Lemon helps brighten pigmentation.

Honey moisturises and heals skin.

Gives a natural glow.

* Aloe Vera Gel Treatment:

All you need is fresh aloe vera gel.

Apply the gel apply on dark spots, before going to bed.

Leave overnight and wash in the morning.

Benefits:

Reduces acne marks and pigmentation.

Soothes irritated skin.

Helps skin repair naturally.

Turmeric and Yoghurt Paste:

You will need 01 teaspoon yoghurt and a pinch of turmeric

Mix the yoghurt and turmeric into a smooth paste and apply on affected areas.

Leave for 15 minutes and then wash gently with lukewarm water.

Benefits:

Turmeric brightens skin naturally.

Yoghurt removes dead skin cells.

Helps fade dark spots gradually.

Use these packs 02-03 times a week as results are generally seen over time.

You can also try this out: Mix a ripe papaya into a smooth paste and apply to the face, or directly on to the dark spots. Leave for 15-20 minutes and then wash with lukewarm water.

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