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Molnupiravir: A Pill to Treat COVID-19

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By Prof. Kirthi Tennakone (ktenna@yahoo.co.uk )

A week ago, pharmaceutical companies, Merck and Ridgeback Biotherapeutics, announced an orally admissible pill that cuts-down COVID-19 hospitalisation deaths by about 50 percent. To imply its power, the drug has been named molnupiravir. According to Germanic mythology, a blow of lightning and thunder emanate when the God Thor strikes his hammer like combat weapon, Mjolnir.

The world is witnessing the strength of vaccines in taming the pandemic. The other weapon absolutely essential to ease the calamity and alleviate the suffering is indisputably a curative medicine – preferably a drug, in pill form, to be taken by mouth.

Antibacterial and Antiviral Drugs

One of the most important conjectures humans continue to maintain is illnesses can be cured by intervention. Henceforth, an untiring effort is diverted to find remedies for every disease and complication. The successes of this endeavor are too numerous to exemplify – to name a few; now we have cures for dreadful diseases such as tuberculosis, leprosy and meningitis.

With the advent of the germ theory of Louis Pasteur, physicians concluded infectious diseases can be relieved if ways are found to kill causative microorganisms in the human body. Pasteur’s work led to the development of disinfection – ways of destroying pathogens harboured outside the human body. Obviously, these techniques are too harsh to destroy germs in the human body.

One hundred years ago, German chemist and physician, Paul Ehrlich, argued that substances attacking bacteria while saving human cells should exist. He said, bacteria absorb certain colourful dyes, leaving human cells intact. Thus dyes and other chemical compounds which selectively interact with bacteria could serve as potent medicines to combat infectious diseases. Inspired by the foresight of a genius; doctors, searched chemical compounds efficacious in curing infections, but innocuous to the human body. In 1935, German physician Gerhard Domagk injected the reddish coloured dye, named prontosil, to his daughter, dying of streptococcal septicemia, and cured her! This was the birth of the sulfonamide – the first broad spectrum antimicrobial. Domagk was awarded the 1939 Nobel Prize for Physiology, citing; he made the dream of Paul Ehrlich a reality and the discovery means nothing less than a revolution in medicine.

The first antibiotic (chemical compound produced one kind of microbes to inhibit the growth of another); penicillin was discovered by Alexander Fleming 1928. Its clinical use, which began in the early 1940s, opened the era of antibiotics and related synthetics. Antibiotics were found to treat almost every bacterial infection, adding 20 odd years to global life expectancy!

Several hundred virus species cause identified diseases in humans – some preventable by vaccination or self-limiting owing to acquisition of natural immunity and a handful responding to curative treatments. Mortality and morbidity of viral disease greatly constrain the healthcare systems all over the world, because a large percentage of the population regularly catch these infections and ready treatments are generally unavailable.

Unlike bacteria, viruses replicate inside host cells intermingling their genetic essence with that of the host. For this reason, it is extremely hard to find agents capable of eliminating the virus without injuring the host cells.

The first antiviral drug Idoxuridine, originated around the late 1950s as a spin-off of cancer research and later found to be a satisfactory cure for herpesvirus infection in eyes and skin. Because of its high toxicity, the drug was prescribed only for topical application. After experience with Idoxuridine; pharmaceutical chemists were of the opinion safe injectable or oral antiviral agents would be an exceptionality. The situation changed when two biochemists Gertrude Elion and George Hitching, initiated a targeted drug design instead of trial and error experimentation. Their work paved the way for synthesis of the potent antiviral drug acyclovir – a safe antiviral used for treatment of herpes, singles and chicken pox. Both received the Physiology Nobel Prize 1988 for work done during the decade, beginning 1945.

Modern targeted antiviral drug design adopt number of different strategies to inhibit viral invasion of human tissue. Mainly; blocking binding of viruses to receptors in cells of the host, arresting escape of the virus genetic material from its outer envelope or introducing agents to derange the replication process.

Most antivirals, currently used and proven to be effective, belong to the third category and referred to as nucleoside analogues. Nucleosides are biochemical molecules, very similar to nucleotides in DNA and or RNA involved in writing of the genetic code. They play an integral role in encoding, transmitting and expressing genetic information. Nucleoside analogue means a molecule tailored slightly different from the naturally occurring counterpart. When the virus mistakenly utilises the analogue which mimic the natural one; the replication process is derailed, stopping proliferation of the virus.

Antivirals widely prescribed to treat influenza, HIV, viral hepatitis, herpes are nucleoside analogous. Remdesvir an approved injectable drug for COVID-19 and the oral molnupiravir, disclosed by Merck, also fall into the same class of antiviral medications.

Molnupiravir: Promising oral COVID-19 drug

Molnupiravir was developed by Drug Innovation Ventures at the Emory University, United States, and patented in 2018, is now classified as an investigational drug for treatment of COVID-19. Originally intended to be tested for treatment of influenza and later shown to be effective in inhibiting SARS-CoV-2 in human respiratory tract epithelial cell cultures and coronaviruses in mice. According to Merck Pharmaceutical Company, in an international clinical trial, molnupiravir, reduced the risk of hospitalisation and death by nearly 50 percent among higher risk people diagnosed with mild to moderate illness.

Mechanism of action: the error catastrophe

Molnupiravir is a prodrug – meaning the active ingredient produced after its metabolism inside the body. Prodrug approach has the advantage in stabilising the active component and lessoning the toxic side effects. Prodrug form allows oral administration. After absorption in intestines and entry into body tissue; molnupiravir is converted into the active component hydroxycytidine which is a nucleoside analogue. This analog mimics two natural nucosides utilised by the virus for its replication. This confusion leads to a progeny of heavily mutated variants of which majority deleterious. The result is the eventual extinction of the virus. Evolutionary biologists refer to this phenomenon as ‘the error catastrophe’.

When a species mutates fast making errors, the species goes extinct when the mutation rate exceeds a threshold.

Judging from the veracity investigations, conducted, and scientific soundness of arguments presented, molnupiravir seems to be something the world is eagerly awaited. Yet rigid science may not grant approval for its wide clinical use without further scrutiny to confirm its efficacy and side effects. Contrastingly, in Sri Lanka some have promoted quackeries with no rational basis whatsoever as cures for COVID-19. Fools rush where angels fear!



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From stabilisation to transformation without delay

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At a symposium on reconciliation organised by the National Peace Council last week, more than 250 religious clergy, civic activists and political representatives from different communities gathered to discuss the country’s future. Speaking at the event, Minister Bimal Rathnayake explained the government’s approach to national reconciliation. He said the government viewed the country’s recovery in terms of a three stage process. The first stage was stabilisation, the second was development and the third was transformation. Reconciliation, he implied, would come in that final stage. The participation of Opposition Leader Sajith Premadasa at the same symposium, and the constructive nature of his comments, strengthens that hope.

When the present NPP government took office in 2024, the country was emerging from one of the gravest crises in its post Independence history. The economic collapse of 2022 had led to shortages of fuel, food, medicines and electricity. Inflation soared, foreign reserves disappeared and long queues became part of daily life. The political upheaval that followed culminated in the resignation of former President Gotabaya Rajapaksa after mass public protests under the banner of the Aragalaya movement. The country was then governed by a leadership that spoke the language of reform and reconciliation but was widely perceived as lacking a direct popular mandate.

Sri Lanka’s past experience suggests that stabilisation and transformation cannot be treated as entirely separate stages. Postponing reconciliation until some future moment risks repeating the failures of the past. If transformation is endlessly delayed until a supposedly perfect moment arrives, there will always be new crises and new reasons for postponement. Minister Rathnayake’s contention that the government’s immediate priority has necessarily been stabilisation flows from the government’s awareness of the precarious situation the country is. Over the past two years, the government has succeeded to a significant extent in restoring economic and political stability. Inflation has reduced, shortages have ended and public institutions have regained a degree of functionality.

Guaranteed Changes

On the other hand, the country’s development continues to face challenges due to adverse global conditions, including disruptions caused by conflict in the Middle East and extreme weather events that have affected tourism, trade and the cost of living. The danger is that reconciliation may be indefinitely postponed in the name of stabilisation. This danger can be reduced if the government works proactively with the opposition and civil society to commence practical measures of transformation now rather than later. The participation of Opposition Leader Sajith Premadasa at the symposium, and the constructive nature of his comments, has strengthened the sense that bipartisan engagement on reconciliation may now be possible.

The urgency of transformation came through strongly in the presentations made by representatives of the Sri Lanka Tamil and Malaiyaha Tamil communities. ITAK parliamentarian S.Shritharan spoke of the frustration caused by unresolved post war issues in the north and east. He referred to disputes regarding land occupied during the war years, including controversies linked to Buddhist temples and state sponsored settlement activity in areas claimed by local communities. He also pointed to the continuing large scale presence of the security forces in the north and east nearly two decades after the end of the war. These grievances have remained central to Tamil political discourse since the end of the armed conflict in 2009. Families displaced by war continue to seek the return of ancestral lands. Civil society organisations in the north have repeatedly called for greater civilian control over local administration and a reduction in military involvement in civilian life.

Academic research and practical work on the ground have shown that reconciliation cannot be separated from questions of dignity, equality and justice. Former minister Mano Ganesan, leader of the Democratic People’s Front, focused on the longstanding problems faced by the Malaiyaha Tamil community. He spoke passionately about continuing housing shortages, landlessness and economic marginalisation, issues that have persisted since Independence. He also highlighted the devastating impact of recent extreme weather events on estate communities that remain socially and economically vulnerable. The condition of the Malaiyaha Tamil community remains one of the enduring social justice issues in Sri Lanka.

After Independence in 1948, a large proportion of them were denied citizenship and voting rights through legislation that rendered them stateless. Though citizenship rights were eventually restored, the social and economic consequences of exclusion continue to be felt generations later.

Many families still lack secure housing and land ownership despite their immense contribution to the country’s plantation economy. Minister Rathnayake’s responses to both these concerns were politically significant. He argued that recent political developments, including the declining influence of narrow ethnic politics across communities, indicated a major shift in public attitudes. According to him, the political ground has changed in ways that make it increasingly difficult for politicians who rely primarily on ethnic division and communal insecurity to retain public support.

Inter-Connected

There is evidence to support the assessment about the changing political grounding which sees future prospects in the resolution of long standing problems. . The economic collapse of 2022 affected all communities alike and generated a new politics centred on governance, anti corruption, accountability and economic justice. The Aragalaya protests brought together Sinhalese, Tamils and Muslims in a common demand for political change. Although ethnic grievances have not disappeared, the crisis created space for a broader understanding that the country’s future depends on cooperation rather than division. Opposition Leader Premadasa’s comments at the symposium reflected this changing political climate. He emphasised that national reconciliation could not be separated from economic justice and the need to address disparities between regions and social classes.v He also mentioned the need for civil society organisations to take this message to the community. This wider understanding of reconciliation is important because ethnic inequality and economic inequality have often reinforced each other in Sri Lanka’s history.

Academic studies have identified the denial of citizenship rights after Independence as a historic injustice that set back the Malaiyaha community for decades. The challenge now is to ensure that transformation becomes part of the stabilisation and development process itself. Practical first steps are both possible and necessary. The release of civilian lands still under state control, greater devolution of administrative authority, reduction of military involvement in civilian affairs, language equality in public administration and accelerated housing and land ownership programmes in the plantation sector are all measures that can begin immediately without waiting for a final stage of transformation.

The government’s recent commitment that provincial council elections will finally be held this year is therefore significant. These elections have been repeatedly postponed by successive governments. Holding them would not solve the ethnic conflict by itself. But it would signal a willingness to restore democratic institutions and share power in a meaningful way.

Sri Lanka has repeatedly postponed difficult reforms in the hope that a more convenient political moment would eventually arrive. But opportunities are invariably created and fought for instead of being provided as a gift by a benevolent government.

The present moment, shaped by the economic crisis and public demand for accountable government, offers a rare opportunity to move simultaneously towards stability, development and reconciliation. Provincial council elections can be the first meaningful step. But they must not be the last.

by Jehan Perera

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Researchers to shape new environmental policy framework

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Some of the researchers at the meeting

In a significant move aimed at steering Sri Lanka’s environmental governance towards a more science-based and evidence-driven path, the Ministry of Environment has initiated a new collaborative mechanism to integrate leading researchers into national policy formulation and conservation planning.

The initiative was discussed at a high-level meeting chaired by Dr. Dammika Patabendi at the Ministry of Environment on Tuesday, where top environmental scientists, wildlife experts and researchers were invited to contribute towards what officials described as a “strategic transition” in the country’s environmental management framework.

The discussions focused on strengthening the scientific basis of environmental conservation programmes and national policy decisions while creating a more research-friendly environment for academics and field scientists engaged in biodiversity and ecological studies.

Particular attention was paid to long-standing concerns raised by researchers regarding procedural and operational difficulties encountered when conducting studies in collaboration with the Department of Wildlife Conservation and the Forest Department.

Minister Patabendi stressed the need for environmental policies to be guided by credible scientific data rather than ad hoc administrative decisions, ministry sources said.

Among the key proposals discussed was the establishment of a streamlined mechanism that would reduce bureaucratic obstacles faced by researchers in obtaining approvals, accessing field sites and sharing scientific findings with state institutions.

The Minister highlighted the importance of building stronger partnerships between policymakers and the scientific community at a time when Sri Lanka is grappling with escalating environmental challenges including deforestation, biodiversity loss, human-elephant conflict, climate-related disasters and ecosystem degradation.

Environmentalists attending the meeting had also highlighted the urgent necessity of incorporating empirical research into national decision-making processes to ensure long-term ecological sustainability and better resource management.

The meeting brought together several of Sri Lanka’s leading environmental researchers and academics including Rohan Pethiyagoda, Saminda Fernando, Sewwandi Jayakody, Samantha Gunasekara, Dinidu Devapura, Himesh Jayasinghe, Manoj Prasanna, Mendis Wickramasinghe and Suranjan Karunarathna.

Director General of Wildlife Conservation Ranjan Marasinghe also participated in the deliberations.

Officials said the proposed framework is expected to pave the way for a more transparent, data-oriented and scientifically credible environmental governance structure capable of addressing emerging conservation challenges more effectively.

The government expects the new mechanism to support the implementation of practical and scientifically robust programmes aimed at safeguarding Sri Lanka’s ecological future while enhancing cooperation between state agencies and the country’s growing community of environmental researchers.

 

By Ifham Nizam

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Back home … for a special occasion

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Seven Notes: Sri Lankans based in Dubai – with Niluk (second from left)

Niluk Uswaththa, of Seven Notes fame, based in Dubai, surprised many when he and his wife Apeksha, turned up in Colombo, last week … unannounced.

Yes, they had a purpose in their surprise visit … to wish Apeksha’s mum for her birthday, which was on Monday, 18th May, and what a surprise it turned out to be!

In an exclusive chit-chat with The Island, Niluk said that the scene in Dubai is improving and Seven Notes do have work coming their way.

Since the members of Seven Notes are all employed (doing day jobs), they operate only on Saturdays and Sundays.

Niluk: Didn’t come prepared to perform, but obliged
friends in Galle

In fact, to get to Colombo for the birthday surprise (on Monday, 18th May), the band had to skip their 17th May, Sunday gig.

“Although it’s a short vacation, my wife and I are enjoying the setup here,” said Niluk, adding that they spent two days in Galle and that their next destination is Anuradhapura.”

Niluk didn’t come prepared to perform, but he obliged the crowd present, at a friend’s birthday celebrations, in Galle, singing and playing guitar.

They are scheduled to leave for their home, in Dubai, in the first week of June.

Seven Notes is an outfit made up of Sri Lankans and the band has been around for almost nine years.

Niluk came into their scene nearly seven years ago.

“When I went to Dubai, I had offers coming my way but it was Seven Notes that impressed me because of their acoustic style.”

The Dubai’s entertainment scene is showing clear signs of bouncing back and even levelling up in the next few months.

Niluk and Apeksha: Enjoying their short vacation

After a slowdown earlier this year due to regional tensions, shows and festivals are back on the calendar, and organisers say late 2026 could be the busiest concert season in years.

Time Out Dubai says “the 2026 concert calendar is filling up nicely” and “the city is ready to party once again” after some reschedules.

Dubai Summer Surprises in July brings retail activations, comedy nights, and indoor art exhibitions.

Organisers point to a backlog of postponed events that are being rescheduled for late 2026 and early 2027.

Yes, Dubai is calm on the surface but on alert. Life is mostly normal in the city, but there’s a “balancing act” as people watch for escalation.

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