Features
Buddhism, Spirituality and Science
(Continued from last week)
The teachings of Gautama must be viewed against the background of pre-existing traditions of Hinduism, the religion to which Gautama himself was born. His philosophy could be seen as a form of protestant revolt against the tenets of orthodox Hinduism. Yet, certain basic Hindu concepts were taken over essentially unchanged, for instance the doctrine of Karma, the inexorable law of cause and effect whereby actions in our present life are thought to have consequences in future reincarnations. Another ancient Hindu concept was the belief that the world abounds in ignorance and misery from which the wise and the pious should endeavour to escape.
Where Gautama differed in a fundamental way from Hindu ascetics of old, however, was the manner in which he sought salvation. His own experience had led him to conclude that excessive self-denial such as fasting practised by Hindu ascetics was futile in furthering this cause. Gautama advocated the so-called ‘Middle Path’, the path that lies between austere asceticism on the one hand and extreme self-indulgence on the other. Furthermore, revolting against long-established Hindu traditions, he rejected the caste system, asserting that all human beings are equal in their potential to accomplish salvation.
Gautama’s first sermon at Varanasi embodies two fundamental pronouncements of Buddhist philosophy: The Four Noble Truths, and alongside it an exposition of the Noble Eightfold Path. The Four Truths are enumerated thus:
(1) Suffering is an essential component of individual existence
(2) The cause of suffering is a craving or attachment for objects of sense
(3) Release from suffering involves the elimination of craving
(4) The elimination of craving is achieved by following the Noble Eightfold Path.
The Noble Eightfold Path itself implies an ethical code of conduct and self-discipline summarised as:
· right knowledge
· right resolve
· right thought
· right speech
· right action
· right living
· right mindfulness
· right concentration.
The ultimate goal to be achieved in Buddhism is seen as freedom from the cycle of birth and re-birth reaching finally the state known as Nirvana. So much is commonly accepted as the bare essentials of Buddhist philosophy derived most directly from the historical facts relating to Gautama Buddha. The details of practice and the specific interpretations given to scriptures, in relation to subjects such as the Nature of the World, have led to the emergence of a diversity of Buddhist sects.
For 2566 years Buddhism has been a major civilizing influence throughout much of Asia and the Far East. The graceful spires and domes of temples and stupas in Sri Lanka, Burma, Thailand and Japan and the murals and sculpture within them bear impressive testimony to the influence of Buddhism upon the art and architecture of these lands. Two centuries after the death of Gautama Buddha his religion had spread across much of Northern India and had just reached the shores of Sri Lanka. Buddhism was deemed to be the state religion of India during the reign of the great Emperor Asoka from 269-237BC. The Buddhism in India at this time, and that which came to Sri Lanka in the latter half of the third century BC were, in their most pristine forms, the religion as preached by Gautama himself.
The scriptures that expound these original teachings are contained in the Tripitaka (the triple basket), a document that was compiled by Indian monks well before the dawn of the Christian Era. The original version of Buddhism is known as Hinayana Buddhism (Buddhism of the Lesser Vehicle) and it is this version that is preserved almost unchanged in modern Sri Lanka. Buddhist doctrines of a generally similar form are also preserved in Thailand and Burma.
In India, however, the dominance of Buddhism over Hinduism was not destined to last. The original Hinayana form, which concentrated almost entirely on individual salvation and was virtually free of ritual, gradually began to incorporate certain aspects of devotional temple worship associated with Hinduism. Already in the first century AD a group of Buddhist monks began to adopt a new and widened interpretation of the teachings of Gautama Buddha. The emergent form of Indian Buddhism took upon itself the cause of salvation of the entire human race in addition to concern for the individual. Because of this wider scope it came to be called Mahayana Buddhism (the Buddhism of the Larger Vehicle).
In general, the Mahayana Buddhist would aspire to the status of ‘bodhisattva’, that is to say one who would eventually become a Buddha. The new Mahayana Buddhism had a more popular appeal and spread rapidly and abroad to Tibet, Korean China and Japan. Whereas Hinayana Buddhism did not change with time in any essential manner in the places where it became established, Mahayana Buddhism on the other hand continued to evolve and take on a diversity of forms. In India, due in large measure to the Islamic invasion, Buddhism was eventually re-absorbed into Hinduism and effectively disappeared as a separate religion around the year AD1300.
Wherever it spread, Buddhism brought with it high moral precepts – tolerance, non-violence, respect tor the individual, love of all nature, a holistic world view and an abiding belief in the equality of all humans.
The liberal tenets of Buddhism are in sharp contrast with the doctrinaire irrationality associated with fundamentalism, in both the Christian and Islamic traditions. Born-again Christians believe in the literal truth of the story of creation, the Earth being less than 6,500 years old. The existence of fossils and their radioactive dating that point to a much greater antiquity of the planet is considered the work of Satan. No amount of rational argument would serve to change this obstinate mode of thought. Nor indeed could the mindset of fundamentalist Muslims be altered by rational argument in regard the atrocities connected with holy wars, jihad or terrorism.
The essence of both Christianity and Islam in their purer forms is a belief in a body of “revealed truth” – God speaking or communicating through the agent of a prophet. Buddhism, however, is markedly different in that its pronouncements are presented to us as an outcome of a process of empiricism. The result of a self-experiment in meditation conducted by none other than the Buddha himself. Indeed in his final words to his disciple Ananda, (Parinibbana sutra) he exhorts us to discover the same truths for ourselves:
“You should live as lamps unto yourselves.
Hold fast to the lamp of Truth.
Take refuge only in Truth.
Look not to refuge to anyone beside yourself…..”
Spirituality has different meanings to different people. The Oxford Dictionary defines:
“spiritual adj. Of spirit as opposed to matter; of the soul esp.; as acted upon by God….”
Traditionally, theistic religions have regarded spirituality as an integral aspect of religious experience. Many people still tend to equate spirituality with religion, but a declining participation in organized religions and the rapid growth of secularism has led to a broader, more liberal view of spirituality.
Spirituality in its most liberal sense carries connotations of a ‘spiritual aesthetic outlook’ which is more individualistic and less structured than the spirituality of the doctrinal faiths of organized religions. The latter often posits the existence a spirit or spirits as evidence of a divine or god-related entity. At one end of the spectrum, even some atheists regard themselves as spiritual, defining “spiritual” as nurturing thoughts and emotions that are in harmony with a belief that the entire universe is, in some way, connected by the flux of cause and effect at every scale. This in my view would be the most appropriate Buddhist interpretation of spiritualism.
Gautama Buddha’s thoughts about the world are in remarkable accord with discoveries in modern science. In Buddha’s analysis of the mind, for example, modern discoveries in psychology would seem to have been anticipated. More impressively perhaps, in his analysis of the Universe recent developments in astronomy have been similarly anticipated. The Earth as a planet around a sun, the sun a star amongst billions in the galaxy, and the galaxy being one of many billion galaxies are propositions that have striking resonances in Buddhist scripture.
In the Visuddimagga, a treatise on Buddhist philosophy written by Buddhaghosa in Kelaniya Sri Lanka in the 5th century of the common era, it is stated explicitly that:
“… as far as these suns and moon’ s revolve shining and shedding their light in space, so far extends the thousand-fold universe. In it are thousands of suns, thousands of moons thousands of Jambudipas, thousands of Aparagoyanas …”, the latter references being to extraterrestrial abodes of life. The billions of galaxies discovered in modern astronomy could be identified with statements referring to the entire Universe as “… this sphere of a million, million world systems”.
Besides correspondences that exist between Buddhist thought and modern psychology and astronomy, even more impressive agreements with fundamental physics have been noted by many commentators. Buddhist ideas of uncertainty (anitya) and dependent causation have striking counterparts in the physics of matter on the scale of atoms and smaller. A major development in the new physics of quantum mechanics in the 1930’s was the discovery of Heisenberg’s uncertainly principle. Not only can the state of an atomic system be observed only within certain well-defined limits, but between one act of conscious observation and the next, the equations of physics have to be reset taking account of the precise state in which the was actually last observed. It is as though the act of conscious interaction with the external world affects the subsequent flow of events. This interaction between human consciousness and the physical world has been interpreted to mean that consciousness itself is a cosmic quality. Our consciousness being part of a cosmic ocean of consciousness.
Buddhist ideas of dependent causation (paticacasamuppada) have also a resonance with modern thinking about the interconnectedness of all things in the world. Gaia is an idea due to James Lovelock that considers all the components of planet Earth, its oceans, atmosphere, climate and life being all tightly interlocked, as they would be within a single living creature. Disturb one tiny component of this system and the entire system reacts. Accepting this fact is of paramount importance for the well being and the future of our living planet. My own ideas and theories of the cosmic nature of life that are rapidly coming to be accepted implies that we are part of a cosmic chain of being that extends to the remotest corners of the Universe. This again is fully consistent with Buddhism.
Since the modern scientific viewpoint is derived from the application of the methods of empirical science, one might wonder how the same results could be reached without, for instance, access to telescopes 2,554 years ago. The answer must lie in the still mysterious and unproven powers of meditation. lf we are all creatures of the Cosmos would it not seem reasonable that we have an innate knowledge of its nature somewhere deep within ourselves? The basic facts relating to the Cosmos could be viewed as essential components of our own true innermost nature.
The Buddha appears to have been reticent on the question as to whether or not there was an omnipotent God who created the universe. In this respect I would interpret the Buddha’s attitude to be one of agnosticism, distinct from atheism. And agnosticism is in my view is the correct intellectual position to adopt. In neither the Hinayana nor the Mahayana traditions is the Buddha himself seen in any way as a God, or an agent possessing extraordinary creative or omniscient powers. This lack of a central God-figure in Buddhism might be seen as a positive attribute, for men have been known in the past to fight bitterly to defend the gods they believed in. It is quite remarkable that Buddhism has spread across vast tracts of Asia and has maintained itself in many countries without recourse to religious wars or crusades.
Buddhism is a philosophy that enshrines peace, compassion, selflessness and universal love as fundamental virtues. Peace to conquer the world, Enlightenment to dispel ignorance and to understand the true nature of the Universe. What better philosophy could there be in the decades that lead us through the 21st century?
(Concluded)
(Professor Chandra Wickramasinghe is an internationally renowned astronomer and astrobiologist. He is currently Honorary Professor at the University of Buckingham in the UK and also Honorary Professor at the National Institute of Fundamental Studies and of Ruhuna University in Sri Lanka.)
Vidya Jyoti Prof. Chandra Wickramasinghe
Features
‘A remarkable time capsule’: The enchanting history of Oxford University’s 750-year-old medieval library
Predating the Aztec Empire, Merton College Library in Oxford has been used by everyone from celebrated 14th-Century mathematicians to JRR Tolkien. In an exclusive interview with the BBC for its 750th birthday, its librarian describes what makes it so special.
At Merton College in Oxford, there is an antique chest. In the Middle Ages, three key-holders had to be summoned to reveal the riches within. But this treasure wasn’t gold or jewels. It was books.
Such strict security may sound overly cautious for mere parchment. But in an era before the printing press, books were a valuable commodity. They could take months to produce, as the entire text had to be painstakingly written out by hand. So, just as universities solicit cash from their alumni today, Merton College insisted its 13th-Century fellows donated books.
“There’s no single definition of a library” – Prof Teresa Webber
The Archbishop of Canterbury issued a decree in 1276 introducing this requirement, which marked the beginning of the library at Merton College. It has been running continuously ever since. To put that length of time in context, Merton’s library predates the Aztec Empire. Its unbroken history stretches from before the Black Death to beyond the Covid-19 pandemic. And its users have encompassed everyone from famous 14th Century mathematicians to Lord of the Rings author JRR Tolkien.
This month marks the library’s 750th anniversary. It’s a major milestone. But Merton’s extraordinary lifespan has been recognised since the Victoria era, when it was routinely described as the oldest library in England.
In the 20th Century, writers like Rudyard Kipling and John Buchan referenced it in works of historical fiction, bolstering its reputation as a particularly venerable library. As the cultural recognition of “the famous Merton Library” grew, claims about its longevity became exaggerated. Some overzealous Oxonians even declared it the oldest library in the world.
The origins of the historic library
Historians today are more careful about making such bold declarations. “It’s a complicated question,” says Prof Teresa Webber from the University of Cambridge. “There’s no single definition of a library. And there were all sorts of stages in the development of what we think of today as a library.”

The origins of the library at Merton are certainly different from how we think of such institutions now. There was no librarian and there were no shelves for browsing. “There was a system of loaning and returning books from the chest,” Merton’s librarian, Dr Julia Walworth tells the BBC. “It would have been a formal thing. Rather than just saying, ‘Oh, go rummage and find the books you need,’ the whole community would come together to open the chest.”
“Horizontal shelves were installed for placing books upright. Merton is the first recorded use in Britain of this method of storing books” – Dr Julia Walworth
Merton’s collection started evolving into a modern library quite quickly. Just a few years after the Archbishop’s decree, several books were stored outside the chest for the first time. They were chained to a table in the college, making them available at any time. According to Walworth, this innovation “anticipates the modern distinction between loan and reference library collections”.
Merton’s book treasury moved closer to becoming a modern library in the 1370s, when a purpose-built room was constructed to house the growing collection. It was here that Merton introduced a vital improvement in book storage. “Horizontal shelves were installed for placing books upright,” Walworth says. “Merton is the first recorded use in Britain of this method of storing books.”
Curiously, Merton’s books were shelved with their spines inwards and their titles inked on the paper facing out. This was due to the continued use of chains, which were clipped on the fore-edge of each book’s cover. “The fellows were aware that chained books had a better chance of survival than books that went out on loan,” Walworth explains.

Today, just a few volumes in the library are chained – purely for display purposes. And the remaining books are now placed in the modern fashion with their spines out. But otherwise, the medieval room remains a remarkable time capsule of the library’s history. Near the entrance, visitors can even see the 13th-Century chest, which Walworth believes is the original. During term time, the historic library room is still used by students. And this ongoing use is a major factor in the superlatives that are often applied to the age of Merton’s library. “It’s hard to think of an earlier library room that’s been in continuous use,” Webber says.
Claims about Merton’s longevity first gained traction in the Victorian era, as it became more of a tourist destination. Visitors would marvel at its stained-glass windows, as well as rare books like its 15th-Century edition of The Canterbury Tales. “It’s one of the earliest books printed in England,” Walworth explains. “What’s unique about Merton’s copy is the hand-illuminated borders.” Among those who visited the library was American writer Ralph Waldo Emerson, who mentioned it in his 1856 travelogue English Traits. In 1884, a young Beatrix Potter visited, describing the library’s “beautiful oak roof” and “ancient, dusty smell” in her diary.
By this time, books and magazines were increasingly describing the library in record-breaking terms. An 1878 guide to Oxford called Merton’s library “the most ancient now in England”. The 1885 edition of the Encyclopaedia Britannica described it as “the oldest existing library in England”. Gradually, these claims were inflated. A 1928 article in The Times recounted an event held by the Oxford Preservation Trust in which it was declared “the oldest library in the world”.

This growing perception of Merton’s longevity was even referenced in F Scott Fitzgerald’s classic novel The Great Gatsby. In the book, the multi-millionaire title character fills his mansion with imitations of history’s most prestigious rooms. So, it’s only natural that his books live in a recreation he refers to as “the Merton College Library”. As Walworth puts it, “Merton’s library had become a byword for the ‘best’ ancient library” by that time. She even points out that Fitzgerald’s fictional scenario had roots in reality. “The dining clubs at Princeton University have historical imitation rooms. One of them is based on the Merton College Library.”
But today, Walworth rebukes any suggestion that Merton’s library is the world’s oldest. She prefers to describe it with several qualifiers, calling it “one of the oldest still-functioning academic libraries in Europe”. That more measured description recognises that not all historic libraries can be categorised in the same bucket – monastic libraries functioned very differently from private subscription libraries, for instance. But it also acknowledges ancient institutions around the globe. “It’s not that people weren’t aware of other parts of the world in the past,” Walworth says. “But there was a tendency for people to think of their own world as having primacy. Our outlook tends to be more global now, quite rightly.”
The debate over the world’s oldest library
Among these global institutions, there are several candidates for the contested title of world’s oldest library. When the Al-Qarawiyyin library in Morocco underwent a major restoration in 2016, it was described by several media outlets as “the oldest library in the world”. But Guinness World Records cites Saint Catherine’s Monastery in Egypt as the oldest continuously operating library.

In both cases, it’s difficult to establish an exact starting date. For the Al-Qarawiyyin library, some scholars have cast doubt on the library’s claims of Ninth-Century origins, saying the “story has much myth about it”. In the case of Saint Catherine’s Monastery, the building was constructed in the Sixth Century. But ancient writings suggest that the library’s collections could date from two centuries earlier. “It depends how you count it,” Walworth says. “When are you going to start the timeline? What is the beginning of a library?”
However, Prof Richard Gameson from Durham University tells the BBC that the library at Saint Catherine’s Monastery “is probably the one with the longest continuous history”. But he caveats this by adding that “the nature of the ‘library’, how it was used and how it was understood changed over time”. So, any claim to be “the oldest” needs to be accompanied by an appropriate explanation of what a library is. Finding a single definition that allows for one conclusive record-holder seems a near-impossible task.
“You can think of the oldest library as the oldest coherent collection of books that stayed together,” says Webber. “Or you can think of it in terms of the survival of the physical space. Or you could ask, ‘What’s the oldest space and collection of books which has been there continuously?'”
She offers the Dunhuang Library Cave in China as an example. This secret chamber was filled with manuscripts and sealed sometime around the 11th Century. It was only opened again after its rediscovery in 1900. “But the books were still in continuous storage there,” Webber says.

Finding a common definition of a library will only become more challenging now, as digital institutions offer physical spaces that do not even contain any books. “The definition of what a library is has always needed to be a capacious one,” says Webber. “The introduction of new technology is simply a continuation of that. But I don’t think the library as a physical space will disappear.”
Walworth is similarly optimistic, as she embarks on a project to digitise Merton’s manuscripts. “People will be able to access them anywhere. But I think they will still want to come and see the library and understand how people used books in the past.”
Reflecting on the 750-year span of Merton’s library, this digital phase seems like just another step in a long evolution. Just as the books moved from the Archbishop’s chest to chained desks to horizontal shelves, now they will enter the virtual realm. “I suppose that’s why I now find it less useful to talk about libraries as ‘the oldest’,” Walworth says. “For me, the story is not about how long a library has been running. It’s more about the sense of community.”
She points out that the tradition of donating books introduced by the Archbishop of Canterbury in 1276 persists to this day. “What started when he laid down those injunctions was the idea of a common collection built by the people. So, it’s just remarkable that for 750 years people have maintained this connection with an institution and its books.”
Perhaps that proves that books really are the most durable treasure – whether they are handwritten on parchment and sealed in an antique chest or distributed as pixels in the cybernetic ether.
[BBC]
Features
Discovery of molecular structure of primary genetic material of life
World DNA Day falls on 25 April:
On 25 April 1953, Watson and Crick published an article, in the acclaimed journal “Nature” titled “Molecular structure of nucleic acids: A structure for deoxyribonucleic acid”.
The one-page article largely based on theoretical arguments and the previous work of Rosalind Franklin who examined DNA using X-rays, changed the world forever by explaining how genetic information is copied and transmitted.
Everyone concerned with promoting science in the country should be aware of the story behind the discovery of DNA and tell it to their children and students and remind the policymakers.
The world commemorates the transformative event on 25th April every year. An example vividly illustrates how intense curiosity and imagination, rather than mere indulgence in technologies, leads to groundbreaking discoveries.
DNA Day is also intended to celebrate the completion of the Human Genome Project in 2003. Genome means the entire set of genetic information characterising an organism.
Heredity and inheritance
Heredity is the cause of transferring traits from parents to their offspring. The closely related word “inheritance “refers to the specific nature of the transmitted trait. For example, we say intelligence is hereditary in their family and he inherited his father’s intelligence.
The resemblance of progeny to parentage was common knowledge, taken for granted and considered a blending of maternal and paternal traits. Philosophers of antiquity proposed several theories to explain the inheritance of parental traits by the offspring. Hippocrates believed the essence of all body parts of the parents are incorporated into the male and female germinal essence and therefore the offspring display characteristics as a proportionate blend. Aristotle offered a different explanation. He argued that the active principle is in the male seminal fluid and the mother’s blood provided the original body material. The inaccuracy of these theories was apparent. Sometimes children possess qualities akin to grandparents rather than parents. Fathers or mothers of humans and animals, deformed by accidents or disease, gave birth to normal children- a clear proof that the acquired characters are not inherited. Children of a blue-eyed mother and a brown-eyed father have either blue or brown eyes but not a blend of blue and brown.
Two golden sayings in our culture, “Arae gathi nare” and “Jammeta wada lokuei purrudha” (“Hereditary characters persist” and “Habits overtake heredity “), agree more with modern genetics, than the views of Hippocrates and Aristotle.
Gregor Mendal’s groundbreaking experiment
The Austrian mathematician cum botanist, Gregor Mendel was the first to conduct a systematic investigation to understand the cause of heredity. Being unconvinced of the traditional explanations, he carried out a series of experiments lasting eight years to determine how the traits (plant height, seed color, flower color etc.) of pea plants are transmitted from generation to generation. When Mendel cross pollinated tall and short plants, he found that the progeny was entirely tall. However, when first generation tall plants were allowed to self-pollinate, the missing short trait reappeared at a statistically significant probability of 25 percent. Mendel’s work provided an unequivocal proof that traits do not blend but exist as unique entities, manifested from generation to generation following a predictable mathematical pattern.
Mendel’s finding remained unrecognized for more than 30 years. His ideas were too far ahead of time and biologists were shy of mathematics. In the early 1900s several European botanists arrived at the same conclusion based on independent experiments. With the advancement of microscopy, a great deal of information about plant and animal cells was gathered. A key finding was the presence of colored bodies in the cell nucleus named chromosomes, seen separating during cell division, leading to the hypothesis that Mendel’s genetic units (genes) should be physical entities present in the chromosomes.
Chemists and biologists wondered what the genetic material in chromosomes made off. Is it a protein, carbohydrate or a lipid? Most biological materials are constituted of these substances.
Discovery of DNA
Great discoveries are made by unusual people. The Swiss Friedrich Miescher belonged to a clan of reputed physicians. Following family tradition, he qualified as a doctor but did not engage in profitable practice of medicine. He decided to do research to understand the foundations of life. In search for new biological substances, he experimented with pus deposited in bandages and extracted a substance rich in phosphates but very different from proteins. The new substance called “nuclein” was indeed DNA. Later, the German biochemist Albrecht Kossel following the Miescher’s work, showed that DNA contains four crucial compounds, adenine (A), cytosine (C), guanine (G) and thymine (T), known as nucleotide bases.
Avery – MacLeod – McCarthy Experiment
The flu pandemic of 1918 killed an estimated 50 million people worldwide due to the pneumonia that followed the viral infection. Pneumonia was caused by the virulent bacterium Streptococcus pneumoniae. The British bacteriologist, Frederick Griffith attempting to find a vaccine for pneumonia, worked with two strains of Streptococcus pneumoniae, one virulent causing pneumonia in mice, and the other avirulent to them. He found that neither the virulent strain denatured by heating nor the live avirulent strain injected into mice caused the disease, whereas a mixture of the denatured virulent strain and the live avirulent strain was deadly to mice just as the virulent one. He concluded that some chemical compound present in the virulent strain – a transforming principle – has changed the avirulent strain to the virulent strain.
In 1944, Oswald Avery, Colin MacLeod and Maclyn McCarty working at the Rockefeller University, United States, continued the work of Frederick Griffith to identify the transferring principle and found that it is not protein as widely believed, but deoxyribonucleic acid (DNA). Their result pointed to the conclusion that DNA is the carrier of genetic information.
A book by a physicist that triggered a transformation in biology
The insights of brilliant brains engaged in fundamental inquiry have opened the way for major scientific discoveries and technological innovations. In 1944, the Austrian theoretical physicist Erwin Schrodinger, one of the founders of quantum mechanics, published a book titled “What is life? The physical aspect of the living cell “. The American biologist Maurice Wilkins said he was so inspired by Schrodinger’s book and after reading it, he decided to switch from ornithology to genetics. While physicist Maurice was influenced to take up biology. Francis Crick was a physicist working on magnetic mines for the British Admiralty during the war. After reading “What is life” he thought a physicist could find treasures in biology and joined the Cavendish Laboratory in Cambridge to pursue a Ph.D.
Structure of the DNA molecule
When DNA was shown to be the molecular entity that encodes genetic information, chemists rushed to determine its structure.
The pattern formed when X-rays passing through a material cast an image on a screen, provides information about its molecular structure. In 1938, the English physicist William Astbury examined DNA using x-rays and concluded that the molecule has a helical structure. Having heard a group in the United Kingdom was attempting to unearth the structure of DNA, the American theoretical chemist, Linus Pauling, adopted Astbury’s data and proposed a model for the structure of DNA, publishing the results in the journal “Nature” in January 1953.
There was an obscure but remarkably talented person, Rosalind Franklin, pursuing x-ray diffraction studies on DNA at King’s College London. After a painstaking effort, she obtained accurate x-ray diffraction images of DNA. Her colleague, Maurice Wilkins, working in the same laboratory, passed the images to Francis Crick and James Watson at Cavendish Laboratory.
Crick and Watson were more insightful and theoretical in their approach to elucidating the structure of DNA. They, inspired by Erwin Schrodinger’s hypothesis, that the entity accounting for heredity should be an aperiodic molecular entity in cells, arrived at the double helix model, showing that Linus Pauling’s model was erroneous. The Crick – Watson model explained how DNA stores information and replicates during cell division. Their assertions were subsequently confirmed rigorously by experimentation. Crick, Watson and Wilkins received the Nobel Prize for Physiology and Medicine in 1962.
The work following the Crick – Watson model, firmly established that the DNA is a polymer string constituted of two strands made of a sugar- phosphate backbone, connected to each other by linkage nucleotide bases A, T, G, C. The base A links base T and G to C. When one strand is defined by the arrangement of bases, the complementary strand is defined. The arrangement bases store information analogously to a four-letter alphabet. Each individual in a species has a unique sequence of arrangement base pairs. The variation within the species is generally a fraction of a percent.
The Watson-Crick model also explained how the DNA molecule replicates. The two strands unwind and separate, and two complementary strands are inserted. The detailed dynamics of the replication process are not fully understood.
‘DNA is a cookbook’
DNA functions like a multiple – volume cookbook, written in a four-letter alphabet. The volumes are kept in a rack in the kitchen. The rack is the nucleus and volumes on it are the chromosomes, and the cell is the kitchen. A paragraph giving a recipe is a gene. Enzymes act as chefs, who read recipes and give instructions to cell machinery to prepare the dishes, which are proteins. The system is so complex; a complete macroscopic analogy would be impossible.
The significance of the Crick- Watson work
Until Charles Darwin proposed the idea of evolution, biology lacked a theoretical foundation. Darwin hypothesized, when organisms reproduce, the progeny inherit parental characters, but there are variations. The variants, though similar to the parents, have some new or altered characters. If these characters, originating from mutations or cross – breeding are favorable for survival in the environment, they dominate in the population, inheriting advantageous traits. Thus, random generation – to – generation, advancements of living organisms, become possible – a way of improving the design of things in a production process without a designer. Living systems store information and progeny retrieve them, when required. A bird hatched from an egg when matured, knows how to fly.
The discovery of DNA and understanding how it stores genetic information, replicates and mutates explained Darwinian evolution. A mutation is a change in the ordering of base pairs, accidentally during replication or due to external chemical or physical causes. In sexual reproduction, the offspring gets nearly half of its DNA from each parent. Consequently, the offspring does not have DNA identical to one parent. It mixes up DNA in the species. However, mutations generate new genes, driving evolution. Sexual reproduction and mutation acting in concert introduced the diversity of life on earth we see today.
Once science becomes explanatory and predictive, it opens the way for innovations. Theories of mechanics and electromagnetism formulated in the late 19th and early 20th centuries brought forth modern engineering, transforming it from an empirical craft to a scientific technological discipline. Before the discovery of DNA structure and its function, biological innovations were largely empirical. Today we have genetic engineering – genes in organisms can be manipulated. The goal of more advanced genetic engineering, referred to as synthetic biology, aims to induce major genetic changes to organisms by incorporating several genes to alter biochemical, physiological and anatomical functions. Gene technology is rapidly transforming medicine, agriculture and biotechnology. Cures have been found for diseases formerly branded incurable.
How did DNA come into existence
Life is believed to have originated in prebiotic oceans enriched with carbon and nitrogenous substances. How did DNA originate there? Today, chemists can synthesize DNA in minutes, via selective procedures, only humans can do with their knowledge. Even in a vast ocean containing trillions of times more molecular ingredients than in a test tube, a molecule as complex as DNA is most unlikely to be created by random events during the largest possible time scales of the universe. A plausible scenario would be DNA evolving from simpler self-replicating molecules such as RNA (a single strand of DNA) precursors. Unlike RNA, DNA is highly stable and good stability is necessary for the evolution of advanced forms of life.
Epigenetics
Earlier we pointed out there are two golden sayings in our culture: “Arae gathi nare” and “Jammeta wada lokuei purudha (“Hereditary characters persist” and “Habits overtake heredity “). The first is a consequence of our genetic predisposition determined by DNA and explicit genes. However, the character of an individual is also influenced by the physical, social and cultural environment. Although completely non-genetic, our children frequently follow habits we indulge in. Again, the behavior of an individual is also influenced by the physical, social and cultural environment.
The environmental factors also trigger or silence genes. The study of this important genetic effect, which does not alter the sequence of base pairs, is referred to as epigenetics. Epigenetic effects could be deleterious or beneficial. Sometimes, chronic stress causes disease, including cancer. Research suggests engagement in creative and imaginative activities, and establishes favorable epigenetic changes in the brain. Inheritance is dictated mainly by the arrangement of base pairs in DNA. Epigenetic changes involve chemical changes in DNA without altering the sequence. These alterations are erasable but allow transmission to subsequent generations.
Conclusion: World DNA day message to lawmakers
The discovery of the structure of DNA stands as one of the most significant scientific discoveries in human history. It is a lesson to all those involved in research and education, telling how great discoveries originated. It is intense curiosity, imagination and preparation rather than mere indulgence in technologies that clear the path for discovery and innovation. A society that advocates policies conducive to discoveries, also develops new technologies that follow. If we just borrow technologies from places where they originated, hoping for quick economic returns, the effort would be a gross failure. Students, determined to be the best judging from exam performance, engage in professional disciplines and perform exceptionally. Why are we short of discoveries and innovations in those disciplines? Will our lawmakers ever realize the issue? They need to wonder why we are weak in science and poor in innovation. Right policies can even reverse adverse epigenetic attributes propagating in a society!
By Prof. Kirthi Tennakone
ktenna@yahoo.co.uk
National Institute of Fundamental Studies
Features
Death of the Sperm Whale
REVIEWED BY Prof. Rajiva Wijesinha
Earlier this year, I sent her most recent book by an old friend, Kamala Wijeratne. Death of the Sperm Whale is her first book of poetry in four years, though in between she has published fiction, two books though both of them too were slim volumes. I am full of admiration for her in that she keeps going, the last of the poets whom I helped to a wider readership in the eighties, when I championed Sri Lankan writing in English, something hardly any academic was prepared to do in those conservative days.
Kamala’s subjects are those she has explored in the past, but the use of the plural indicates that her range is expansive. She dwells much on nature, but she deals also with political issues, and engages in social criticism. There are several poems about Gaza, the multiple horrors occurring there having clearly affected her deeply. She repeatedly draws attention to the slaughter of children, the infants sent by God only to be taken back. And she deals with the destruction of the life of a doctor, after his healing, a theme that has kept recurring in the ghastly world which is subject to the whims of the incredibly nasty Netanyahu.
The title poem is about a whale destroyed by ingesting plastic, a tragedy to which we all contribute, though those who ‘loll on the beach, their senses dulled by the burgers they eat’ could not care less. More immediate is the simple account of a friend whose infant had died in hospital, when they diagnosed pneumonia too late.
Contrasting with these urgent statements are Kamala’s gentle perceptions, as when she writes of her son supporting her as she walks, while she thinks back to the days she supported him; of a marigold growing in a crack in a shrine, offering obeisance with its golden flowers to the Noble One; of birds investigating her dining room and deciding not to build there, the male lingering ‘confused and irritated’ but eventually following the female through the window for ‘She was mistress after all.’
She is deeply interested in the passing of time, and its impact on our perceptions. The first poem in the book is called ‘First Poem of 2024’ when she ‘heard the weeping of the dying year’, and went on to meditate on how we have categorised the passing of time, while the universe moves on regardless.
She welcomes the return of the Avichchiya, the Indian Pitta, a bird that has figured previously in her poetry, after six months, but this time she spares a thought for his case against the peacock, which stole his plumes.
There are two personal poems, one about a former student who turned her back on her when she had achieved success, the other about being nominated for a literary award, but not getting it after the excitement of attending the Awards Ceremony. Swallowing her disappointment, she congratulates the winner, noting that she will not go into ecstasies the next time she is nominated.
Paraphrase cannot do justice to Kamala Wijeratne’s gentle touch, which has expanded its reach over the years. So,A I will end by quoting from her tribute to Punyakante Wijenaike, another of the distinguished ladies whose work I promoted, the one before the last to leave us. The tribute ends, recalling her most impressive work Giraya,
Like the nutcracker
That makes a clean cut
You cut the human psyche
To reveal its darkest depths
by Kamala Wijeratne
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