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What is this vaccine against covid-19?

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By Dr. Kavindya Marapana

COVID-19 has impacted millions of lives worldwide. Sri Lanka reported its first case of COVID-19 on 27thJanuary 2020 and since then the epidemic has affected Sri Lanka significantly, especially since the second wave of COVID-19 in October 2020, causing a severe health, economic and social burden. Globally, whilst many people may have asymptomatic infection, around 40% of the infected persons develop a range of mild symptoms which include fever, a new and continuous cough, shortness of breath, sore throat, fatigue, loss of appetite, diarrhoea, etc. Only around 15% of the patients develop severe complications such as pneumonia, and out them around 5% suffer from life-threatening diseases including severe respiratory distress syndrome, thromboembolic events and multi-organ failure. In Sri Lanka, 79, 999 cases have been identified to the date of writing and although the incidence of COVID-19 related complications seem to be low, 445 deaths have been reported up-to-date, including paediatric deaths. COVID -19 is also believed to have long-term effects on neurological system which is still in research stage.

The Ministry of Health has introduced a Covid-19 vaccine, which is considered safe and efficacious as evident from the available information about vaccine trials. Given the high priority requirement of safeguarding essential healthcare facilities of the country, adhering to global Covid-19 vaccination prioritization guidelines and recommendations by the National Advisory Committee of Communicable Diseases, healthcare staff and other support frontline workers have been inoculated.

Over 280 different COVID-19 vaccines are at various stages of development. Some have been made with the help of currently available vaccine technology, and completely new approaches have been adopted in producing others. While it normally takes several years to develop a vaccine, scientists across the world have worked collaboratively and expeditiously to achieve the same amount of work in a few months to make a safe and effective vaccine available as soon as possible. Although clinical trials have been carried out more rapidly than they have for other vaccines, this has been achieved by conducting some of the steps in parallel rather than sequentially and vaccine safety has not been compromised.

With the initiation of the vaccination programme in Sri Lanka, lot of questions have been raised by the public and we believe to answer a few common questions that have been raised frequently with the expertise of Dr. Chintha Karunasekara, Consultant Microbiologist at Lady Ridgeway Hospital for Children.

 

What is the vaccine given to
the Sri Lankans at the moment?

It is the COVISHIELD vaccine made by the Serum Institute of India (SII) that is brought down to Sri Lanka as the first batch of vaccines against corona virus. It is the same vaccine as the COVID-19 Vaccine AstraZeneca (ChAdOx1nCoV-19 Corona Virus Vaccine-Recombinant) developed by the University of Oxford but is developed to be effective at the temperatures of South Asian countries.

 

How does it protect me against COVID-19?

It is a viral vector vaccine, which uses a safe, weakened virus (adenovirus) which does not have the ability to multiply inside the body. It is genetically engineered to include a protein of SARS-C0V-2 (SARS-Cov-2 spike S) which triggers an immune response in the body against the COVID-19 virus, which protects the body from the possibility of developing disease or severe disease leading to death. The virus in the vaccine is destroyed after introducing the protein in the body. After the first dose of vaccine, the second dose is recommended to be taken in four weeks time. But the latest studies are recommending to increase the gap between the two doses up to 12 weeks for increased efficacy. The duration of protection by the vaccine is still not confirmed and is currently being studied. Therefore, with the current data it may require for it to be repeated yearly.

 

Is it safe for me to take it?

The COVID-19 vaccine AstraZeneca is currently under phase 3 vaccine trials and is found to be the most safe and efficacious vaccine among the vaccines currently being used. But there are instances where the vaccination should be strictly avoided and informed to the vaccination team without hesitance;

Known allergic reactions to the constituents of the COVISHIELD vaccine (L-Histidine, L-Histidine hydrochloride monohydrate, Magnesium chloride hexahydrate, Polysorbate 80, Ethanol, Sucrose, Sodium chloride, Disodium edetatedihydrate (EDTA), Water for injection)

History of severe allergic reactions leading to hospital admission or anaphylaxis.

Pregnancy , lactation and in children less than 18 years (not enough evidence is still available for the safe use of the vaccine among these groups)

Special precautions are to be taken if you are having a disease affecting bleeding and coagulation.

There are special situations where the vaccination is to be postponed for 4 to 8 weeks, and those are;

If you have any symptoms suggestive of COVID-19.

If you are suffering from an acute illness and not fit for the vaccination.

If you are already diagnosed with COVID-19 and received anti-CoV 2 monoclonal antibodies or convalescent plasma as a treatment option.

Being under regular treatment for long term diseases is not a reason to avoid the vaccine. But those conditions must be communicated to the doctor prior to the vaccination.

 

Why should I take it? Can I still be protected against COVID-19 without the vaccine?

Vaccination is one of the powerful public health interventions to combat this pandemic. Two key reasons to take the vaccine are to protect ourselves and to protect those around us. After vaccination most are protected from disease and severe disease. Vaccination curbs the spread of the virus by reducing the number of infections in a population.

The more people are immunized, the better the chances of reaching herd immunity. Herd immunity is even unvaccinated people in a population can be protected from a certain virus, like COVID-19, if a certain threshold of vaccination is reached in that population. Likewise, vaccines protect individuals, also protect communities.

 

Does it protect me for lifetime?

Once an individual is vaccinated, how long will their immunity to Covid-19 last? To answer this question more data from vaccine trials have been collecting and it depends on how a vaccine performs and how SARS-CoV-2 acts in the real world. For more longer immunity may need a booster vaccine.

 

Can I still transmit the disease to
those who are around me?

Vaccines are typically designed to prevent people from getting sick with the virus, but it is not yet clear if the COVID-19 vaccines can stop you from transmitting the virus to others. This is why is it important for people to continue taking precautions such as physical distancing, hand washing, wearing masks and avoiding gatherings, especially in poorly-ventilated spaces

But the most recent studies have shown the COVID-19 AstraZeneca vaccine to reduce the risk of transmission by 67%, which is a ray of hope that in the near future further developments would take place to further reduce the transmission.

The more people are immunized, the better the chances of reaching herd immunity.Herd immunity is when a population can be protected from a certain virus, like COVID-19, if a threshold of vaccination is reached

 

How bad can the side-effects be?

Around 75% of the healthcare personnel who received the vaccine reported to have mild to moderate symptoms as a result of the ongoing immune reaction following the vaccination. The most commonly reported symptoms were fever (low to high grade), chills, rigorus, muscle and joint pains, fatigue, lethargy, loss of appetite and vaccine site pain and swelling.

Less commonly abdominal pain, minor allergic reactions, enlarged lymph nodes have been reported but severe allergic reactions, anaphylaxis have not been reported so far in Sri Lanka.

The vaccination programme which is started by the government with the frontline healthcare workers is now started in stages to reach the rest of the population in Sri Lanka and the type of vaccine could be different to COVISHIELD, which we hope to write about in the future.

 

 



Features

The challenge of keeping value-based politics alive

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Anti-migrant protests in Durban, South Africa. BBC

The current outbreak of anti-immigrant protests in Durban, South Africa is bound to have taken many a subscriber to value-based politics or political idealism quite by surprise. After all, this is evidence that despite the historic accomplishments of nation-builders of the stature of the late President Nelson Mandela it cannot be taken for granted that identity politics, including racism in its worst forms, is no more in South Africa.

At the time of this writing details are scarce on the substantive root causes of the protests but it could very well be that economic grievances, particularly on the part of the majority community in South Africa, are contributing considerably to the disaffection. Shrinking employment and material prospects are likely to figure majorly among the factors igniting the unrest.

Fortunately, the local authorities in Durban are losing no time in calling for peaceful co-existence among the relevant communities and are pointing to the vital importance of stepping-up national integration processes. Apparently, immigrants in sizable numbers from neighbouring countries are present in Durban. However, international TV footage of the protests quoted some local authorities as saying that the majority of the immigrants in some centres that housed them were not illegal migrants and had the documents that entitle them to be in Durban.

In the Durban protests the world has fresh proof of the socially divisive consequences of the gathering globe-wide economic disaffection, touched off particularly by the continuing crisis in West Asia. Going ahead, the world would need to brace for increasing identity-based unrest of the kind it is just witnessing in South Africa.

Considering that the material lot of ordinary people everywhere could only aggravate progressively, with the US and Iran showing no signs of negotiating an end to their confrontation any time soon, it will be left to the more democratic and progressive sections of the world community to initiate positive measures collectively to bring a measure of relief to the discontented.

The swiftness with which such relief will be provided would depend crucially on the importance those sections taking up these undertakings attach to value-based politics as opposed to Realpolitik of power politics.

Going by these yardsticks, Italy could be considered to be moving in the right direction. Recently Italy came to the fore in initiating the collective named, ‘Rome Coalition for Food Security and Access to Fertilizer’, which has as one of its aims the swift provision of fertilizer to economically weak African countries.

In a recent statement Italian Minister of Foreign Affairs and International Cooperation, Antonio Tajani, said that a principal aim of the project was to ensure that the farmers of Africa gained easy access to fertilizer, considering that food security is a growing concern among some of Africa’s economically vulnerable countries.

The statement went on to mention that some 30 countries hailing from the Mediterranean region, the Middle East, the Balkans as well as the FAO had been invited to join the coalition. The venture is far-seeing in that food security is main among the reasons for social discontent which in turn could degenerate into endemic political turmoil and bloodshed. Separatist violence and geographical fragmentation of countries wouldn’t be too far behind these developments, as Africa itself has often proved.

It is hoped that more G7 countries would take the cue from Italy and do what they could to ease the hardships of economically distressed countries, particularly of the global South. In these efforts they would need to break rank with the US, which is today brutally indifferent to the consequences of its policy of making ‘America First’, come what may.

Going by current developments, the Trump administration seems to be blithely oblivious to the wider, deleterious effects of its policy course in West Asia. Besides rendering Iran militarily and otherwise impotent nothing else seems to matter to Washington, as regards West Asia. This is policy short-sightedness of an extreme kind. After all, right now West Asia could be said to be sitting on the proverbial powder keg.

On the other hand, Iran is not giving the world the impression that it is doing anything constructive to get out of the policy straitjacket that it wove for itself decades ago. Rather than enter into a policy of ‘live and let live’ in relation to Israel in particular and initiate a process of reconciliation with the latter, it has chosen to operate within policy parameters that continue to damn Israel. This has put Israel always on the ‘defensive’ so to speak and prevented the opening up of space for meaningful dialogue.

That said, Israel is obliged to explore the possibilities of entering into a negotiatory process with the Arab-Islamic world that could lead to a de-escalation of tensions and bloodshed. It cannot continue to look at its neighbours through lenses that distort them as archetypal enemies who should be ‘wiped off completely from the face of the earth.’

In other words, the need is urgent for Realpolitik to give way to value-based politicks. Italy is beginning to prove that the latter approach could be pursued with some success. May be the EU and the UK could throw their weight behind these initiatives as well and establish that international politics could be refashioned on the basis of humane, civilized norms. The UN would need to be fully supportive of these moves and prove an organizational nucleus of the operations that follow.

In fact the time is ripe for people of conscience to collectively stand up on the side of peace and say ‘No’ to war and violence. Organizations such as the ICRC, the WHO and Medicines Sans Frontiers have already taken up this call. Referring to the widespread destruction of health facilities and their dehumanizing results these organizations have said, among other things, that ‘This is not a failure of the law. It is a failure of political will.’

True, ‘failure of political will’ among those powers that matter accounts for the runaway, uncontrollable nature of war and destruction in contemporary times, but more fundamentally it is a failure of the human conscience. It could very well be that the phenomenal levels to which violence and war have been unleashed today have had the effect of deadening consciences. This is a matter for urgent study and wide discussion.

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Features

Vesak celebrations … with Cuteefly

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Perfect for celebrations, gifts, and meaningful occasions // Gift pack

I would describe Indunil Kaushalya Dissanayaka as innovative and creative, and she operates under the name of Cuteefly.

Indunil always comes up with something novel to celebrate special occasions, and she does it with candles … and that’s her profession.

She was in the spotlight when she created a happening scene, with candles, for Christmas, Sinhala and Tamil New Year, and Valentine’s Day.

As lanterns light up Sri Lanka for Vesak, the Colombo-based candle maker is quietly turning wax and wick into little pieces of the festival.

Candles reflecting Vesak themes

Her candles reflect Vesak themes – light, peace, remembrance, giving, etc., to enable you to fill your Vesak celebration with devotion and beauty.

Among her Vesak creations is a lotus-shaped soy candle, scented with sandalwood, lavender, etc., meant to burn during this Vesak Poya Day.

Indunil Kaushalya Dissanayaka: Customers
praise her for her creativity

These handcrafted Vesak candles are perfect for offering at the temple, she says.

What makes her creations so novel is that they come in different shapes, scents, themes, and all are handmade.

What’s more, her customers have heaped praise on her for her creativity.

According to Indunil, her creations are perfect as a thoughtful gift … to bring beauty, unity, and light into every moment.

Says Indunil: “Our beautifully handcrafted Unity candles are designed with premium detail and love, making them perfect for celebrations, gifts, and meaningful occasions.”

Cuteefly, says Indunil, is available online.

Readers could contact Indunil on 0778506066 for more details.

He Facebook Page is: Cuteefly.

Handmade with love

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Features

Dark Spots …

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Yes, dark spots do crop up on the skin, especially with sun exposure and, of course, as the skin ages.

However, these tips should be of immense benefit to those who are faced with dark spots.

Lemon and Honey Glow Mask:

You will need 01 teaspoon lemon juice and 01 teaspoon honey.

Mix the lemon juice and honey well and then apply this mixture, only on the dark spots.

Leave for 10–15 minutes and then rinse with cool water.

Benefits:

Lemon helps brighten pigmentation.

Honey moisturises and heals skin.

Gives a natural glow.

* Aloe Vera Gel Treatment:

All you need is fresh aloe vera gel.

Apply the gel apply on dark spots, before going to bed.

Leave overnight and wash in the morning.

Benefits:

Reduces acne marks and pigmentation.

Soothes irritated skin.

Helps skin repair naturally.

Turmeric and Yoghurt Paste:

You will need 01 teaspoon yoghurt and a pinch of turmeric

Mix the yoghurt and turmeric into a smooth paste and apply on affected areas.

Leave for 15 minutes and then wash gently with lukewarm water.

Benefits:

Turmeric brightens skin naturally.

Yoghurt removes dead skin cells.

Helps fade dark spots gradually.

Use these packs 02-03 times a week as results are generally seen over time.

You can also try this out: Mix a ripe papaya into a smooth paste and apply to the face, or directly on to the dark spots. Leave for 15-20 minutes and then wash with lukewarm water.

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