Features
Ivermectin: A missed opportunity?
By Dr Upul Wijayawardhana
In recent times, no drug has aroused more controversy than Ivermectin, an anti-parasitic discovered in 1975, originally used in veterinary medicine. It was approved for human use in the late 1980s and is on the World Health Organization’s List of Essential Medicines. William Campbell and Satoshi Omura won the 2015 Nobel Prize in Physiology or Medicine for its discovery and applications which include mass administration in the prevention of lymphatic filariasis and river blindness. In addition to anti-parasitic activity, Ivermectin has been shown to have anti-viral activity as well as anti-inflammatory activity.
Laboratory tests showed Ivermectin activity against the Covid-19 virus at high concentrations, and, therefore, it was initially thought that toxicity might be a problem if used in very high dosage. However, as some observational studies showed benefit at normal doses, Ivermectin was promoted as a ‘miracle’ drug through social media, mostly by anti-vaxxers. A big impetus for Ivermectin came from a randomised clinical trial of 400 patients from Egypt, published in early 2021, which showed a 90% reduction of death rates. However, a British medical student who studied the trial in detail found many discrepancies including plagiarism and data manipulation, which led to the retraction of the article in July 2021.
The first step in proving the efficacy of a drug or any other intervention is by observational studies. If they show likely benefit, then Randomised Clinical Trials (RCT) are done, where one group receives the drug and the other gets a placebo of similar appearance. The most rigorous of all are the double-blind RCTs, where neither the patients nor the triallists are aware who is on what unyil the trial is concluded, and this which helps eliminate any form of bias. The validity of the trial increases as the numbers treated increase. In fact, there are instances where a drug that had been shown to be effective in small RCTs were proven to be ineffective when large RCTs were conducted. This has led to the concept of mega-trials, where thousands of patients are included. The earliest and the best known are the ISIS trials conducted by the Oxford Research Group, which showed the efficacy of clot-busters in the treatment of heart attacks.
However, it is not always easy to do large trials which could be expensive and time consuming. Therefore, statisticians have developed a new method of pooling comparable trials and analysing data, which is called meta-analysis. The August issue of the American Journal of Therapeutics carried a meta-analysis of Ivermectin trials by Bryant et al from the UK, which concluded: “Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using Ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally”. Unfortunately, this meta-analysis included data from the disgraced Egyptian study.
Another meta-analysis, also from the UK by Hill et al, published in ‘Open Forum Infectious Diseases’ initially showed positive results including a 56% reduction in mortality, but a revised publication, after deleting the data from the Egyptian trial, concluded that Ivermectin did not show a statistically significant effect on survival though it displayed a borderline significant effect on duration of hospitalisation in comparison with standard care. This clearly illustrates how the conclusions from a meta-analysis can change due to what is included in the analysis. In fact, statistics can be manipulated to get the desired result!
Perhaps, the important message from these two meta-analyses is that Ivermectin may do some good and does not seem to be doing any harm. Maybe, it was this message that Prof Saroj Jayasinghe wished to convey in his article “Ivermectin and Covid: no time to lose and lives to save” (The Island, 17 September 2021). Although some non-medical scientists were critical that his suggestions were unscientific, it is to his credit that, in a grave situation, he made sensible recommendations, giving good reasons why he was doing so. It may well be that the medical fraternity in Sri Lanka listened to the words of wisdom by a respected senior colleague of the profession, which has resulted in the relatively very low death rate in Sri Lanka. Whereas the average daily deaths are around 20 in Sri Lanka, it is around 182 in the UK: three times the rate when adjusted to the size of the population in spite of having better health care facilities and higher vaccination rates. In fact, on 8 January the UK joined the US, Brazil, India, Russia, Mexico and Peru, as the seventh country to have more than 150,000 Covid-19 deaths during this pandemic.
When it was announced in June that Ivermectin is to be investigated as a possible treatment for COVID-19 in Oxford’s PRINCIPLE trial, there was optimism that the issue of effectiveness of Ivermectin would be resolved, at last. This was because of the reputation of the Oxford Group, which has done pioneering research during the pandemic, in addition to producing the most widely used vaccine with the collaboration of AstraZeneca. However, when I searched for an update, I found this disappointing headline in ‘Medpage Today’ website: “Ivermectin Arm of PRINCIPLE Trial Put on Hold — Trial website cites supply issues”. It went on to state:
“The website does not offer any details on what caused the Ivermectin supply difficulties in PRINCIPLE, which is investigating possible treatments for COVID-19 and being led by the University of Oxford in England. A full response from the trial’s press team was promised, but had not reached MedPage Today by press time.
Ivermectin manufacturer Merck did not directly comment on the supply issues affecting PRINCIPLE. However, as part of a longer statement on the drug provided to MedPage Today via email, the company said that it has “concluded that the probability of ivermectin providing a potentially safe and efficacious treatment option for SARS-CoV-2 infection is low and have prioritised internal efforts towards the development of alternate candidates that provide a higher probability of success for the treatment of COVID-19.”
The alternative candidate they refer to, of course, is Molnupiravir which would be hugely profitable for Merck unlike Ivermectin, which is off-patent. Although initial studies suggested a 50% reduction of hospitalisation with a course of Molnupiravir tablets, final data shows only a modest reduction of 30%. Merck has allowed Indian drug firms to manufacture and sell Molnupiravir at low cost in developing countries. Still, a course will cost around Rs. 4,000 whereas a course of Ivermectin costs less than Rs 200!
It seems very surprising that Oxford Group has difficulties in obtaining a cheap drug and I do not know whether they are obliged to obtain their supplies from the original manufacturer. It is even more interesting that no other news channel has highlighted this problem. On 6 October 2021, BBC website printed a lengthy investigative report titled “Ivermectin: How false science created a Covid ‘miracle’ drug”. I would have expected these investigative journalists to follow the progress of Ivermectin studies but they seem to be silent!
Let us hope Oxford Group obtains supplies and concludes the trial. Otherwise, their reputation too will be at stake. It would be interesting if Ivermectin, a repurposed drug, outperforms Molnupiravir, a targeted drug developed specifically for Covd-19. Repurposing is not a new phenomenon. Many drugs introduced for one purpose sometimes become more useful in other conditions. Thalidomide, introduced as a cure for morning-sickness, fell into disrepute as it caused foetal deformities but has found a new life as an anti-cancer drug. Of course, the best known is Sildenafil, a vasodilator that was trialled by Pfizer for angina; it produced an interesting side effect, which led to it being marketed as Viagra, one of the biggest money-spinners for Pfizer!
Features
Putting people back into ‘development’ – a challenge for South
Should Sri Lanka consider an 18th IMF programme? Some academicians exploring Sri Lanka’s development prospects in depth are raising this issue. It is yet to emerge as a hot topic among policy and decision-making circles in this country but common sense would sooner rather than later dictate that it be taken up for discussion by the wider public and a decision arrived at.
The issue of an 18th IMF programme was raised with some urgency locally by none other than Dr. Ganeshan Wignaraja,Visiting Senior Fellow, ODI Global London, one of whose presentations, made at the Regional Centre for Strategic Studies (RCSS), Colombo, was highlighted in this column last week, May 7th. An IMF programme is far from the ideal way out for a bankrupt country such as Sri Lanka but a policy of economic pragmatism would indicate that there is no other way out for Sri Lanka. Such a programme is the proverbial ‘Bird in the hand’ for Sri Lanka and it may be compelled to avail of it to get itself out of the morass of economic failures it is bogged down in currently.
While local economic growth possibilities are far from encouraging at present, such prospects globally are far from bright as well. Some of the more thought-provoking data in the latter regard were disclosed by Dr. Wignaraja. For example, ‘The IMF’s April 2026 World Economic Outlook projects global growth slowing to 3.1 percent in 2026; with downside risks dominating: prolonged conflict, geopolitical fragmentation, renewed trade tensions, bearing down hardest on emergent and developing economies.’
However, as is known, an ‘IMF bailout’ is fraught with huge risks for the people of a developing country. ‘The Silver Bullet’ brings hardships for the people usually and they would be required by their governments to increasingly ‘tighten their belts’ and brace for perhaps indefinite material hardships and discontent. For Sri Lanka, the cost of living is unsettlingly high and 20 percent of the population is languishing below the poverty line of $ 3.65 per day.
These statistics should help put the spotlight on the people of a country, who are theoretically the subjects and beneficiaries of development, and one of the main reasons, in so far as democracies are concerned, for the existence of governments. Placing people at the centre of the development process is urgently needed in the global South and shifting the focus to other considerations would be tantamount to governments dabbling in misplaced priorities.
Technocrats are needed for the propelling of economic growth but a Southern country’s main approach to development cannot be entirely technocratic in nature. The well being of the people and how it is affected by such growth strategies need to be prime focuses in discussions on development. Accordingly, discourses on how poverty alleviation could be facilitated need urgent initiation and perpetuation. There is no getting away from people’s empowerment.
In the South over the decades, the above themes have been, more or less, allowed to lapse in discussions on development. With economic liberalization and ‘market economics’ being allowed to eclipse development, correctly understood, people’s well being could be said to have been downplayed by Southern governments.
The development issues of Southern publics could be also said to have been compounded over the years as a result of the hemisphere lacking a single and effective ‘voice’ that could consistently and forcefully take up its questions with the global powers and institutions that matter. That is, the South lacks an all-embracing, umbrella organization that could bring together and muster the collective will of the South and work towards the realization of its best interests.
This columnist has time and again brought up the need for concerned Southern sections to explore the potential within the now virtually moribund Non-Aligned Movement to reactivate itself and fill the above lacuna in the South’s organizational and mobilization capability. In its heyday NAM not only possessed this institutional capability but had ample ‘voice power’ in the form of its founding fathers, with Jawaharlal Nehru of India, for example, proving a power to reckon with in this regard. The lack of such leaders at present needs to be factored in as well as accounting for the South’s lack of power and presence in the deliberative forums of the world that have a bearing on the hemisphere’s well being.
The Executive Director of the RCSS, Ambassador (Retd) Ravinatha Aryasinha, articulated some interesting thoughts on the above and related questions at a forum a couple of months back. Speaking at the launching of the book authored by Prof. Gamini Keerewella titled, ‘Reimagining International Relations from a Global South Perspective’, at the Bandaranaike Centre for International Studies, Colombo, Amb. Aryasinha said, among other things: ‘Historically, there is a precedent that has been realized by the Non-Aligned group of countries – unfortunately, rather than being reformed and modified at the end of the Cold War, it has been tossed away.’
The inability of the nominally existent NAM to come out of its state of veritable paralysis and voice and act in the name of the South in the current international crises lends credence to the view that the organization has allowed itself to be ‘tossed away.’ The challenge before NAM is to prove that it is by no means a spent force.
As indicted, NAM needs vibrant voices that could advocate value-based advancement for the global South. Moral principles need to triumph over Realpolitik. Such transformative changes could come to pass if there is a fresh meeting of enlightened minds within the South. Pakistan by offering to mediate in the ongoing conflict between the US and Iran, for instance, proved that there are still states within the South that could look beyond narrow self-interest and work towards some collective goals. Hopefully, Pakistan’s example will be emulated.
Along with Pakistan some Gulf states have shown willingness to work towards a de-escalation of the present hostilities in West Asia. This could be a beginning for the undertaking of more ambitious, collective projects by the South that have as their goals political solutions to current international crises. These developments prove that the South is not bereft of visionary thinking that could lay the basis for a measure of world peace. That is, there are grounds to be hopeful.
NAM needs to see it as its responsibility to make good use of these hopeful signs to bring the South together once again and work towards the realization of its founding principles, such as initiating value-based international politics and laying the basis for the collective economic betterment of Southern people.
Features
Artificial Intelligence in Academia: Menace or Tool?
(The author is on X as @sasmester)
I have often been told by university colleagues how soulless and dangerous ‘artificial intelligence’ (AI) is to academia and humanity. They lament that students no longer read anything as they can now get various AI programmes to summarise what is recommended which is mostly in the English language to Sinhala or Tamil or get easier versions in English itself. They get their assignments and even dissertations fully or partially written by AI. And I am led to believe that universities do not have reliable detection software to assess plagiarism and academic fraud that have been committed using AI beyond the software freely available on the internet with their own limitations. This is due to financial restrictions in these institutions. Even these common malpractices have been done mostly with the aid of free AI programmes which are readily available, which means cheating in this sense is free and mostly safe. For teachers, this is a ‘menace’ in the same way ‘copying’ once was. But its implications are far worse.
But given the global investments made over AI, it cannot be wished away despite the enormous negative impact its use has on the environment, particularly due to its massive demand for energy. So, AI is with us to stay, and it has a considerable role to play in human civilisation even though like most innovations and inventions, this too carries its own burden of negativity. In this context, instead of demonising AI and lamenting its replacement of human agency and ingenuity, one needs to think seriously about how to deal with and engage with it reflectively and pragmatically as there is much it can offer if people are intelligent enough to make rational and sensible choices.
When I am making these observations, I am restricting myself to a handful of practices involving only writing both in university-based examination processes and in the fields of creative writing.
My initial introduction to AI was through the Research Methods class I used to teach in New Delhi. In 2022, this class was supposed to go to Dharmshala in Uttar Pradesh for fieldwork training, and we needed to write a funding proposal quickly. One of the students in the class, already familiar with ChatGPT introduced by OpenAI as a free programme in 2022, did the proposal with its help before the two-hour class was over. I edited it soon after and sent it off to the university administration for funding which we received. That stint of field work was completed in five days and was the most detailed work undertaken as a training programme up to that time in the university which had considerable output ranging from a documentary film to a detailed ethnography based on the findings.
While the technical details, the format of the proposal and its basic writing were done by AI due to the time constraints the class faced, its fine-tuning was done by me and a few students. AI could not then and even now cannot undertake that level of specificity without close human intervention. But the film, the ethnography and the actual process of research had nothing to do with AI. It was the result of human labour, thinking, planning and at times creativity and ingenuity. This was an early example of how AI could coexist in an academic environment if its technical usefulness was clearly understood and potential for excesses was also understood. But this was a time, easily accessible AI was just emerging, and we did not know much about it. But I was fortunate enough to have intelligent students in my class who gave me a crash course into this kind of AI use, which I followed up with my own reading and experimentation later on. As a result, I am keener now to see how it can be used for the betterment of academic practice rather than taking an uncritically demonising position, which I know will not lead anywhere.
But how is this possible? The lamentations of my colleagues about the abuse of AI in academic practice is not unfounded. It is a serious threat that remains mostly unaddressed not only in our country but almost everywhere else in the world too. This is mostly because the advancements of AI even in day-to-day free usage have far exceeded any thoughts for actionable codes of ethics to ensure its practice is sensible and ethical. At the same time, I cannot see why a student should not use AI to correct his spelling and grammar in assignments. I also cannot see why a student cannot seek AI’s help to secure research material from secondary sources available online which I have been doing for years. For instance, the originals of specific books and rare manuscripts might not be available in any repositories in our part of the world. In such situations, what AI might find us is all we have access to in a world where we are restricted in our mobility due to semi-racist visa regimes of failed empires and former superpowers as well as our own lack of ability to travel due to our own unenviable economic conditions. But unfortunately, the materials we need are often only available in research centers and libraries in those nations.
Similarly, when it comes to academic prose, it makes no sense now to take years to translate works from multiple languages to Sinhala and Tamil. This has always been a time-consuming, cumbersome and expensive process. Non-availability of Sinhala and English translations of core originals in languages such as English, French, German and so on has been a long-term problem for our country. But this can now be done well – at least from English to our languages – quite quickly and with a very low margin for error by using specific AI programmes which are meant to do precisely this. What this means is a quick expansion of knowledge in local languages which would have ordinarily taken years to achieve or might not have been possible at all. But still, this needs significant human intervention and time towards perfection. However, I do not think AI-based translations work as well for fiction and poetry or creative works more generally. But the ability for AI to emulate nuance and feeling in language is fast emerging. These are two clear examples of improving technical abilities in research and writing in which AI can be of help.
But looking for sources of information with help the help of AI or using it as a tool to undertake essential translations from one language to another is quite different from simply using it without ascertaining the accuracy of collected information, getting AI to do all your work without any reflection or without any hard work at all, including engaging AI to do the final product in a writing assignment — be that a term paper or a work of fiction. If one proceeds in this direction, as many unfortunately do nowadays, then, our ability to think and be creative as a species will become diminished over time and our sense of humanity itself will take a toll. This is what my colleagues worry about when they say AI is making younger generations soulless.
It is here that ethical practices on how to use AI responsibly without compromising our sense of humanity must play a central role. But these ethical practices must be formally written and taught, followed by viable programmes for detection and publication if unethical practices are followed. This needs to be the case particularly in teaching institutions as well as the broader domain of creative writing. After all, what is the fun in reading a novel or a collection of poetry written by AI?
It is time people began to think about what AI can do in their own fields without falling prey to its power and their own laziness. This brings to my mind Geoffrey Hinton’s words: “There is no chance of stopping AI’s development. But we need to ensure alignment; to ensure it is beneficial to us …” Similarly, as Yann LeCun observed, “AI is not just about replicating human intelligence; it’s about creating intelligent systems that can surpass human limitations.” In this sense, it is up to us to find our edge in creativity and common sense to find the most sensible way forward in using AI.
Features
Engelbert’s 90th birthday bash
The legendary Engelbert Humperdinck, who is known for his hit songs such as ‘A Man Without Love’, ‘Release Me’, ‘Spanish Eyes’, ‘The Last Waltz’, ‘Am I That Easy To Forget’, ‘Ten Guitars’ and ‘I Can’t Stop Loving You’, turned 90 on 02 May, 2026, and there were some lovely Hollywood-related celebrations.
Before his birthday, Engelbert’s new single ‘I’ve Got You’ was released – on 23 April – and Engelbert had this to say: “‘I’ve Got You’ is especially close to my heart. It speaks to love, loyalty, and the quiet strength we find in one another”.
The main birthday event was held at The Starlight Cabaret, in Los Angeles, California, and Sri Lankan Raju Rasiah, now based in the States, and his wife Renuka, who are personal friends of Engelbert, were invited to participate in the celebrations, along with Ingrid Melicon – also a Sri Lankan, now domiciled in America.
The invitation said “An evening of music, memories and celebration. Let’s make it a night to remember!” And it certainly turned out to be a night never ever to be forgotten!

Invitees experienced a “magical entrance” with Engelbert’s name lighting up the screen and showing him performing his hit songs.
The invitees were also presented with a unique gift – a necklace with Engelbert’s face, engraved with the words “Remember, I Love You.”
Engelbert’s son, Bradley Dorsey, sang a tribute song ‘Only You’ for his dad, while Eddy Fisher’s daughters, Tricia and Joely, also got on stage to entertaining the distinguish gathering.
Engelbert didn’t perform but got on stage for the cutting of the birthday cake.
There was also a video compilation of birthday wishes from fellow celebrities, and the lineup included Gloria Gaynor, Micky Dolenz, Wayne Newton, Pat Boone, Lulu, Judy Collins, Deana Martin, Angélica María, Rupert Everett, Matt Goss, and more.

Birthday boy Engelbert Humperdinck
At 90, Engelbert is still performing. He’s on THE CELEBRATION TOUR for his 90th year, with over 50 international dates in 2026, including Australia, Germany, the US, and Canada. He’ll be at Massey Hall in, Toronto, on 06 October, 2026. He said: “The stage is my home… Canada has always been a highlight”.
He performed 60+ concerts, worldwide, in 2025, and says karaoke keeps his songs fresh: “Most of my songs are on karaoke because people love to sing them”.
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