Features
Has evolution found ways to prevent cancer and halt progression to old age?
By Prof.Kirthi Tennakone
The high incidence of cancer alarms us. Around six percent of the human population worldwide suffers from cancer. It is the most challenging health issue to resolve and the leading cause of death, only second to cardiovascular disease. More than 10 million people die of cancer every year. In some regions, cancer deaths exceed heart disease mortality because of the availability of more successful preventive and curative measures for the latter.
With all these fears, the relief and the promise are cancers occur less frequently than expected. Many live beyond 100 years without contracting cancer but die because of other natural causes. Animals also get cancer, but there are species exceptionally resistant to it. And evolution has found solutions to suppress malignancy. Following them would be a hopeful avenue to prevent and cure this dreadful malady.
DNA damage, the primary cause of cancer is also a factor that induces our progression to old age. Evolution seems to have found clues to address both problems in one stroke.
Cause of cancer
Nearly 40 trillion cells of different kinds constitute our bodies. All of them carry the same genetic material (DNA) unique to the individual but some express only a portion of the encoded genetic information. Cells divide constantly to produce new cells for growth and replace those that naturally die. Each day, several trillion cells divide, replicating the DNA, and copying the mode of genetic expression. The replication, prone to random error, may not be exact, sometimes leading to mutations. Cancer is caused by mutant cells with altered genetic expression. Even one such mutant cell could cause the disease because it can divide and multiply. According to the above scenario, multicellular organisms are inherently subjected to the threat of cancer. Environmental influences such as pollutants and radiation could indeed induce malignancy in normal cells. Even if these external triggers are eliminated, cancer occurs because of molecular accidents in the process of cell division. Most of the time, someone getting cancer is not the fault of an external cause or a habit. Of course, this wouldn’t mean that the prevalence of cancer is not increased by external influences and habits. Exposure to mutagenic chemicals, radiation and many habits notably; chewing betels, alcohol and smoking has been proven to increase the risk of cancer.
Multicellular life
Life on Earth originated about 4 billion years ago. The primitive forms of life were self-replicating molecules created in prebiotic oceans via a yet unknown process. Fossil evidence suggests single-cell (unicellular) microbes appeared 3.7 billion years ago. They acquired more and more capabilities via several steps of evolution and finally gained a propensity to agglomerate into colonies – macroscopic structures or blobs made up of the same kind of cells.
The pivotal epoch in biological evolution was the period beginning about 600 million years ago when multicellular organisms with colonies of specialised cells emerged. Cells in all the colonies contain the same DNA but specialised by closing the expression of some coded information and manifesting selected genes. This mechanism provided animals and plants with organs cooperatively interacting with each other for the benefit of the organism. The division of biochemical and physical functions between different organs was an unprecedented adaptive advantage – multicellular life diversified, dominating the earth. The strategy is analogous to the division of labor as society advances. Primitive humans, although they liked to segregate, each undertook all essential tasks such as gathering food, building shelter and making tools. Later, they abandoned some tasks and specialized. There were farmers, carpenters, smiths and physicians; cooperatively working together for mutual benefit.
The fact that multicellular organisms evolved from a unicellular microbe remains latent in their developmental process. All animals and plants begin their lives as single cells that divide, differentiate and expand spatially according to a plan written in the genetic code. Billions of years of evolution have perfected the scheme. Yet, multicellular life encountered three inevitable biological hurdles; infection, carcinogenesis and aging, leading to death.
Microbes (mostly unicellular) invade multicellular organisms, causing disease. Mutations introduced during DNA replication or due to external influences such as chemicals in the environment or radiation cause cancer. Irreversible chemical changes in the body lead to aging and eventual death.
Evolution attempts to find solutions to every problem confronting life. The immune system fights invading microbes to prevent infection, a similar mechanism eliminates mutated cells causing cancer and repair processes prolong life.
Peto’s paradox
Every cell in the body of an animal has a non-zero probability of giving birth to a carcinogenic daughter cell as a random uncontrollable event during cell division and proliferate developing tumors. Therefore, larger- bodied animals carrying a greater number of cells should be more susceptible to cancer and very large animals would go extinct because of carcinogenesis.
In 1776, the English epidemiologist and statistician Richard Peto pointed out among animals there is no correlation between body size and incidence of cancer. The absence of the expected relationship between body size and the incidence of cancer is referred to as Peto’s paradox.
Elephants and humans have similar life spans, but the former are built out of nearly 100 times more cells than the latter. If the risk of cancer relates to cell content, the prevalence of the condition in elephants would be so high that almost every one of them will prematurely die of cancer. However, elephants are known to be highly resistant to cancer, with an incidence estimated to be five times lower compared to humans. Whales are thousands of times bulkier than humans and known to live 200 years or more. These gigantic animals live so long because they have acquired an exceptional resistance to cancer. A few dinosaur fossils indicative of bone malignancy have been discovered. Undoubtedly, cancer in these reptiles was very rare. Otherwise, they could not live long enough to reach extraordinary sizes and dominate the earth for 160 million years.
The fact that big made individuals in the same species are more likely to have cancer than small made indicates the Peto’s paradox is evolutionary in origin.
How do these giant animals resist cancer? Elephants have 20 copies of the gene named T53, whereas humans and most mammals have one. The gene T53 gives instructions to synthesize a protein P53, which acts as a tumor suppressor facilitating the repair of damaged DNA. Whales are believed to adopt a similar technique to eliminate malignant cells.
Gigantism favors animals to repel predators and easily feed by roaming around. However, a large enough number of these animals cannot grow to massive sizes and reach reproductive age, without suppressing carcinogenesis. Small animals reach maturity early and have shorter life spans and cancer would not be a threat to the survival of the species.
Naked mole rat: an animal that keeps cancer at bay
The naked mole rat is one of the most fascinating animals we have on this planet. A subterranean mammal about the size of a domestic mouse and distantly related to it. Lives in arid regions of East Africa, borrowing kilometers – long tunnels 1-2 meters below the ground. A strict vegetarian feeds on roots and tubers and never drinks water. Their bodies are pinkish with sparingly distributed hair, accounting for the name they earned. Protruding incisor teeth help it to dig tunnels even in hardened dry soil. The animal is virtually blind and senses the environment mainly by the tactile facility of its hair. Mole rats are social animals governed by a queen who associates one or two princely mates, reproduces and supervises a colony of about three hundred members, giving vocal commands. All other females and males are sexually inactive workers who dig tunnels, take care of young and serve the royalty. If the queen dies, females fight to the death and one who succeeds in securing the ‘throne’ becomes sexually active.
A mole rat lives more than 40 years, showing no apparent signs of physiological aging. The queen lives longer and continues to reproduce. Related animals of similar size live only 2-3 years. Mole rats are resistant to infections and tolerate very low levels of oxygen without asphyxiation. And most importantly keep cancer at bay – no evidence of cancer in thousands of animals examined, except one or two zoo animals. They die of tunnel accidents or snake attacks when they reach heavily guarded tunnel vents.
Current research has revealed mole rats possess tumor suppressing genes. They give instructions to repair damaged DNA and produce agents that inhibit tumor growth. Perhaps, the same genes effectively suppress ageing. One of the main causes of human and animal aging is genomic instability, the failure to repair DNA deteriorating in replication or due to chemical influences. These are also the primary biomolecular events responsible for cellular carcinogenesis.
Recently, longevity genes of mole rats have been successfully transferred to mice. Amazingly, an increase in life span and a betterment of health were observed. In the future, similar procedures may rejuvenate youth in humans! After all, the effort of the alchemists of antiquity to find an elixir of immortality may not be entirely absurd.
Unprecedented healthy longevity of mole rats is a lesson to humans.
We humans live in an elusive atmosphere of a brightly lit carnival, do everything possible for pleasure, curiosity and economic advantage, but have failed to resolve imminently crucial issues, good health free of cancer, neurodegenerative diseases and rapid aging. The naked mole rat living in dark ill – ventilated narrow tunnels beneath the ground has solved these problems. Humans need to look at the workings of animals more closely and preserve their habitats.
The author can be reached via email: ktenna@yahoo.co.uk
Features
Dilemmas of ‘hurting economies’ – the case of Sri Lanka
Maldives President Dr. Mohamed Muizzu was in Sri Lanka recently on what was apparently a goodwill visit and this event, no doubt, bodes very well for Maldives-Sri Lanka relations. Besides, the visit would go some distance in strengthening Sri Lanka’s claims to Non-Alignment.
However, the commentator on regional politics could be accused of simplistic thinking if he/she glosses over or ignores the regional politics nuances or undertones of the Maldivian President’s visit. In Sri Lanka we currently have a government which is eager to solidify its bridges, so to speak, with China and which, given the chance, would be courting increasingly close relations with Russia. In other words, the NPP government is likely to see itself as a ‘natural ally’ of the East and would prefer to distance itself to the extent possible from the West, if that is a realistic proposition.
Given the foregoing backdrop, it would be in some of the NPP regime’s best interests to be on cordial terms with the Maldives which is a close ally of China in the South Asian region. However, the NPP government, given the utter financial helplessness of Sri Lanka, cannot afford to distance itself politically and diplomatically from India and the West. Sheer economic necessity compels Sri Lanka to adopt this foreign policy stance. In other words, the latter has no choice but to be ‘Non-Aligned.’
This columnist was led to the above observations on listening to a lucid and comprehensive presentation titled, ‘A Global Economy in the Shadow of the Iran War and implications for Sri Lanka’s debt recovery’, by Dr. Ganeshan Wignaraja, Visiting Senior Fellow, ODI Global London, at the Regional Centre for Strategic Studies (RCSS), Colombo on May 4th. The forum, RCSS Strategic Dialogue – 4, was moderated and presided over by RCSS Executive Director Ambassador (retd) Ravinatha Aryasinha.
The forum brought together a wide cross section of society, including diplomatic personnel, academicians, public and private sector personalities and the media. After the presentation a very lively and informative Q&A followed.
Ambassador Aryasinha at the outset set an appropriate backdrop to the presentation and discussion by stressing ‘the increasing interconnectedness of geopolitical and economic developments, noting how disruptions in the Middle East could have significant ramifications for global markets, trade flows, energy prices and broader economic stability, including Sri Lanka.’
Indeed, there are occurring currently very disruptive economic and material consequences for the world from ‘the Iran War’, and with US-Iran hostilities spiraling in West Asia it may not be wrong to surmise that the worst could be yet to come, unless a peace process materializes in earnest.
Meanwhile, ‘hurting countries’ such as Sri Lanka would need to summon their best economic management capabilities to remain materially and economically afloat. ‘Economic transformation’ is what is urgently needed and not mere management and some of the insights thrown up by Dr. Ganeshan Wignaraja should have the local polity thinking.
There was the following observation, for instance: ‘Sri Lanka has achieved remarkable cyclical stabilization but faces critical challenges in transitioning to transformative growth, with 2027-2028 debt repayments looming and only $5.4 billion usable reserves.’
Needless to say, the path ahead to ‘transformative growth’ for Sri Lanka is strewn with multiple challenges and meeting them effectively is of the first importance. Sri Lanka must soldier on towards even a semblance of development in the short and medium terms and such initiatives cannot be separated from its foreign policy choices since the country’s economic partners and their growth prowess have a close bearing on the country’s material fortunes.
As mentioned, Sri Lanka will be compelled to be ‘a friend of all countries and an enemy of none’ going forward but it cannot afford to be seen as cultivating China as a close growth partner at the expense of India and other major economies of the region.
This is primarily because while India is remaining a major economic power, the current West Asian crisis notwithstanding, China’s economy is being seen as ‘slowing’. Dr. Wignaraja singled out the following in the main as the factors causing this slow-down: a bursting property bubble, increasing state regulation, and weakening investor confidence. Besides, the speaker sees production cycles moving away from China and India replacing China and Hong Kong as ‘manufacturing hubs’.
Accordingly, the NPP regime in Sri Lanka would need to craft its regional policy in particular with the utmost far-sightedness. It will need to have close economic links with all the growth centres that matter.
On the question of authentic economic transformation, the following observations of Dr. Wignaraja on Sri Lanka’s economy are of the first importance as well: ‘Foreign reserves are now at $ 5.4 billion, the cost of living is high, an estimated 20 per cent of the population lives below the poverty line of $ 3.65 per day, the recent cyber security breach at the Treasury would affect some 10 payments.’ These factors were termed ‘critical vulnerabilities’.
It is difficult to conceive of an economic transformation worthy of the phrase minus a steady economic empowerment of the populace. The above data point to the considerable magnitude of the local poverty problem. Right now, the disruptive effects of the West Asian crisis render swift poverty alleviation a most difficult proposition.
One possible way out of the present economic debacle is the forging of a national consensus by the present government on all outstanding problems that have been bedeviling the country’s advancement. That is, there needs to be a meeting of minds across current political divides. Considering the present inflammatory political polarities in Sri Lanka this would prove an insurmountable challenge.
Unfortunately, conscience-filled and civic minded sections in Sri Lanka have chosen to be laid back rather than seize the initiative, come centre stage and impress on politicians the need for enlightened governance and progressive change. There needs to be a historic coming together of the right thinking to ensure that the best interests of the people and of the people only are served by governments. In the absence of such a process, might would be projected as right and brute force would come to increasingly rule politics and society.
Features
Australia funds project to restore climate-resilient vegetable livelihoods in cyclone-affected highlands
The Ministry of Agriculture, Livestock, Lands and Irrigation, the Government of Australia, and the Food and Agriculture Organization of the United Nations (FAO) have launched of a AUD 2 million (USD 1.4 million) recovery initiative to restore and transform vegetable production systems in the cyclone-affected districts of Nuwara Eliya and Badulla.
The FAO said yesterday (5) that the agreement was formalized through the signing of the grant agreement by Matthew Duckworth, Australian High Commissioner to Sri Lanka, and Vimlendra Sharan, FAO Representative for Sri Lanka and the Maldives, alongside the signing of the project document by D. P. Wickramasinghe, Secretary of Agriculture.
Cyclone Ditwah, which struck Sri Lanka in November 2025, caused widespread devastation across the country, severely disrupting agricultural production systems and livelihoods. The highland districts of Nuwara Eliya and Badulla, key suppliers of vegetables such as beans, carrots, leeks, cabbage, tomato and potato, were among the hardest hit, with thousands of smallholder farmers losing crops, seed stocks, and productive assets.
This 12-month initiative aims torestore and strengthen climate-resilient vegetable production systems, with a strong focus on empowering women farmers and supporting persons with disabilities. The project will directly benefit more than 2,400 smallholder farmers, through improved seed and seedling production systems, small machinery, training, and market linkages while indirectly supporting thousands more.
“This initiative is an important step not only in restoring what was lost, but in building a more resilient and self-reliant agricultural sector,” said Minister Lal Kantha. “By strengthening local seed systems and supporting smallholder farmers, particularly women and vulnerable groups, we are investing in the long-term sustainability of Sri Lanka’s food systems.”
“Australia stands alongside Sri Lanka in its ongoing recovery from Cyclone Ditwah,” said High Commissioner Duckworth. “Australia is a steadfast partner in the agriculture sector with its importance for food security, rural development and climate resilience. By focusing on climate smart practices, farmer-led solutions and inclusive economic opportunities, this project will deliver meaningful and lasting benefits to affected communities.
The project will prioritize the restoration of farmer-led seed systems for beans and potatoes, support the re-establishment of both open-field and protected cultivation systems and women led seedling supply nurseries while empowering all farmers with Climate-Smart Good Agricultural Practices (CSGAP) with small scale machinery and input support.
A key feature of the initiative is the establishment of six accessible and inclusive nurseries in Nuwara Eliya and Badulla. These nurseries will serve as sustainable agri-based enterprises, producing high-quality vegetable seedlings while creating new income opportunities and strengthening local input supply chains.
By combining recovery support with long-term resilience measures, the project will help stabilize vegetable production, improve household food security and nutrition, and reduce reliance on imported seeds.
Features
War on Iran may hasten unraveling of New World Order
It took several decades for the US to realise it was losing the war in Vietnam. It took a bit shorter time in Afghanistan. And what is happening in the countries the US and Israel intervened and broke up? The US has been asked to leave Iraq. Syria is talking to Russia about establishing military bases, President al-Sharaa met with Vladimir Putin in Moscow to discuss the project, which is vital for Russian power projection in the Middle East. Libya has been divided into two competing administrative units with the Eastern section actively engaged with Russia in defence matters. The Sudanese government has finalised a 25-year deal to allow a Russian naval facility in the Red Sea in exchange for weapons, including anti-aircraft systems. On the Eastern side of the Red Sea, Yemen remains divided, with the main power center, the Houthis maintaining a staunchly anti-US, anti-Israel stance, while the internationally recognised government remains in exile.
When the Iranian Foreign Minister recently undertook a tour of Pakistan, Oman and Russia, the US wanted to meet him and got ready to send its negotiators Vice President J. D. Vance and his team to Pakistan, but Iranian FM snubbed them and left Pakistan, saying Iran did not want to talk to the US while a blockade of their ports were in place. The Iranian FM met President Putin, who congratulated Iran for courageously defending their country and then phoned US President Trump and told him further attacks on Iran would not be acceptable. During this conversation on April 27, 2026, Putin reportedly warned Trump that further U.S. or Israeli attacks on Iran would have dangerous consequences, according to Al Jazeera). Such a sequence of events would not have been possible in the unipolar world we had in the past.
Furthermore, the damage that Iran has inflicted on the US and Israel in this war would have been unimaginable in the late 20th Century and early 21st Century. Sixteen US military bases spread across Saudi Arabia, Qatar, UAE, Bahrain, Kuwait, Iraq, Jordan and Oman have been either destroyed or severely damaged. Advanced surveillance aircraft and radar systems worth more than $ 2.8 bn were destroyed. This had a far-reaching effect on the war as the US could not use these bases in the war against Iran and also in the defence of its allies in the Gulf.
The attacks on Israel have been equally damaging. In Central Israel and Tel Aviv area multiple attacks targeted military and intelligence assets, resulting in massive damage. Iranian missiles hit the Haifa oil refinery, causing a shutdown, and hit residential buildings, leading to injuries and structural damage. Residential and commercial areas were damaged in Bat Yam and Petah Tikva with significant casualties and destruction. Attacks in Dimona and Arad targeted the Negev Nuclear Research Center, with casualties reported in both towns. The Soroka Medical Center in Beersheba was hit in a strike. The strategic port and naval base in Eilat were targeted. In Rishon LeZion suburban residential areas suffered extensive damage.
Usually, Israel makes short work of its many enemies in the region, for example it took just six days to defeat the combined military of Egypt, Jordan and Syria in 1967 and grab their land as well. Hamas, Fatah and Palestinians would suffer ignominious defeats if they dare challenge Israel. However, the recent war against Hamas, following a daring wide scale invasion into Israel by Hamas in October 2023, went on for more than two years with no conclusive victory for Israel.
These significant massive military setbacks suffered by the combined forces of the US and Israel have been made possible by the unprecedented advancement in military technology achieved mainly by China and to a degree by Russia as well. Iran has been able to develop ballistic missile systems that could penetrate the “iron dome” that Israel boasted, with technological assistance from China and North Korea. Iran’s drones are very cheap yet very effective, requiring interceptors worth millions of dollars to counter them, thus making it much more costly for the US to fight this war than it is for Iran.
Further, Hezbollah in Lebanon, Houthies in Yemen and Hamas in Palestine are well equipped with advanced missiles and drones. Hezbollah has been able to destroy about hundred Israel tanks and stop their advance. According to Larry Johnson, former CIA intelligence analyst, Israel soldiers are much war weary and mentally affected and are being withdrawn. Netanyahu’s 40 year dream of a “Greater Israel” is telling on the poor soldiers.
If a person like Barack Obama had been the US President instead of the hyper egoistic, blustering, intellectually barren Trump, things may have been different. An attempt would have been made to reconcile with the fact that the world is changing, instead of trying to stop it and make “America Great Again”. Perhaps, it could be said that Trump is facilitating the emergence of the new world order by enabling the US citizens to see the reality, the futility of war and the fact that Israel is a liability because the US is fighting its war. Further, the war has enabled Iran to assert its place in the region and negotiate from a position of strength.
Perhaps, Israeli people may realise that the Palestine problem cannot be solved by militarily occupying their land, and that in a changing world a “Greater Israel” is a “pie in the sky”. They may have to agree to a two-state solution. US support may not always be forthcoming, certainly not at the level that Trump could extend, as this war is very unpopular and expensive. The other very significant fact is that Israeli settlers in the occupied lands feel insecure and one in three wants to leave and the numbers may grow when Palestinians and their sympathisers grow in strength in the new world order.
Moreover, the war on Iran has afforded China the opportunity to demonstrate with authority the fact that it stands for universal peace and does not tolerate illegal wars. Its message to the US conveyed its world view and its desire for peace in no uncertain terms. Trump cannot afford to disregard the Chinese position on the war on the eve of his visit to that country which may decide on future trade between the two countries as the US depends on China for several essential materials like rare earth minerals. Furthermore, China has shown that peace could be achieved by developing the economies of the underdeveloped countries irrespective of their alliances. It helps Iran as well as Saudi Arabia and try to build bridges between these foes. It welcomes Trump in the coming weeks and hopes to strengthen ties between the two countries despite the weaknesses of the latter.
Another important factor is the gradual decline of the critical value of the petro-dollar. Following the end of the gold standard in 1971, the US struck deals with Saudi Arabia and other OPEC nations (around 1974) to price oil exclusively in USD in exchange for military protection and arms sales. Dollars earned by selling oil came to be known as petro-dollar. Oil producers, holding large dollar surpluses, reinvest these funds in the US Treasury securities, real estate, and financial assets ensuring the recycling of petro-dollars. The system ensures a consistent global demand for US dollars, which helps fund the US budget deficit and maintains the currency’s dominance.
However, the petro-dollar system is on the decline and there are two main reasons for this, firstly the gradual rise of the new world order with organisations like BRICS, making a concerted effort to extricate from the dollar dominance by developing alternate currencies and methods to bypass the dollar. Secondly, the need felt by most countries to develop alternative energy sources to replace enormously harmful fossil fuel would eventually result in a decline in the demand for it and consequently the effectiveness of the petro-dollar. China is leading the world in both these endeavours; depolarisation process and renewable energy production. The war on Iran seems to have hastened the process of depolarisation as Iran insists that it will sell its oil for yuan only.
These revolutionary changes in the aftermath of the Iran war have their undeniable implications for the Global South, where more than 60% of the poor live.
by N. A. de S. Amaratunga
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