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Treatments for dengue: a Global Dengue Alliance to address unmet needs

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Global Dengue Alliance

The importance of developing a treatment for dengue has largely been ignored, the Dengue Alliance said in a statement.However, a recently formed Global Dengue Alliance with several institutions in dengue-endemic countries, plans to accelerate research and development and deliver dengue therapeutics through an inclusive partnership.

Formation of this alliance is a major step towards developing a treatment for dengue, by aggregating resources from endemic countries, and ensuring engagement, scientific leadership, clinical guidance, and political interest in these countries.

Dengue is currently the most rapidly spreading mosquito-borne viral infection in the world, with half of the world’s population at risk of becoming infected. As a result of climate change, rapid urbanisation, and widespread international travel, the incidence of dengue is rapidly increasing, overwhelming healthcare systems in many lower-income countries. Climate change has increased the burden of dengue in endemic countries and has also led to expansion of this infection to new territories in Europe and North America.

Dengue is estimated to infect approximately 390 million individuals annually, with 96 million infections being symptomatic. So far, the only strategy adopted to reduce the burden of dengue is vector control. Although techniques such as using Wolbachia bacteria to reduce dengue transmission by Aedes mosquitoes look promising, it is evident that vector control alone is unlikely to be adequate to reduce the burden of dengue.

The currently available dengue vaccines (CYD-TDV and TAK-003) have been shown to reduce hospitalisations, especially in dengue-seropositive individuals, but lack efficacy against some dengue virus serotypes. Furthermore, CYD-TDV showed a higher incidence of severe dengue in dengue-naive vaccine recipients, and both vaccines show some degree of waning immunity with time, especially in seronegative individuals. Therefore, an integrated approach that comprises vector control, use of safe and effective vaccines, and an effective treatment is needed to face the growing challenges of dengue infection.

Efforts focused on finding a treatment have been scarce, with some investigator-led clinical trials conducted, and a few performed by pharmaceutical companies. The importance of developing a treatment for dengue has largely been ignored. The Drugs for Neglected Diseases initiative, which is focused on finding novel affordable treatment solutions for neglected tropical diseases since its inception in 2003, has recently formed a Global Dengue Alliance with several institutions in dengue-endemic countries, including the Faculty of Medicine at Siriraj Hospital, Mahidol University in Thailand; the Ministry of Health in Malaysia; the Translational Health Science and Technology Institute in India; the Oswaldo Cruz Foundation in Brazil; and the Federal University of Minas Gerais in Brazil. The mission of this alliance is to accelerate research and development and deliver dengue therapeutics through an inclusive partnership.

It aims to deliver a new treatment for dengue, within five years, from repurposed drugs and combinations (including novel antivirals from pharmaceutical companies). This alliance is co-created, co-owned, and co-funded by dengue-endemic countries, with a tiered governance mechanism allowing collaborative decision making at different levels. The organisations have formed a preclinical working group, a clinical working group, and a translational working group for effective communication and scientific planning.

All three working groups feed into the Joint Steering Committee, which is responsible for delivering on the vision and mission of the alliance. The partners of this alliance share knowledge, experience, technologies, and capabilities to jointly validate preclinical assays with the ambition in the initial phase to identify currently available drugs that can be repurposed for use as dengue therapeutics. In parallel, clinical trials for these drug candidates are being designed using the expertise of clinicians in these countries who have been treating patients with dengue for many years, with initiation planned by the end of 2023.

Formation of this alliance is a major step towards developing a treatment for dengue, by aggregating resources from endemic countries, and ensuring engagement, scientific leadership, clinical guidance, and political interest in these countries.

The different working groups and the steering committee coordinate efforts to address gaps in knowledge, such as epidemiology (specifically in Africa), biomarkers and diagnostics, clinical trials, and regulatory framework, while promoting open science. Although currently the alliance has a small number of partners, it is open to collaborations with new partners and key stakeholders in therapeutics and diagnostics.

Working with and aligning many partners and stakeholders to deliver objectives in a new model of collaboration is challenging, as is filling the existing knowledge gaps and need for integration, and leveraging information from different geographies and epidemiological settings. Furthermore, doing clinical trials aimed at treating dengue disease is challenging due to the seasonal nature of the disease, and with climate change, disease patterns could become more unpredictable.

Although this approach is likely to accelerate development of a treatment, funding remains a challenge. With climate change becoming more of a concern in high-income countries, there is an increasing possibility that many global funding organisations will acknowledge the true burden of dengue, the devastation it causes to health systems and patients in endemic countries, and, therefore, the importance of funding initiatives to accelerate the development of new treatments for dengue.



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Civil society activist accuses govt. of favouring Ven. Gnanasara

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Galagodaatte Gnanasara / Viyangoda

Court of Appeal issues warrant for monk’s arrest

by Shamindra Ferdinando

Civil society activist Gamini Viyangoda on Monday (28) lambasted the NPP government for its failure to act promptly on the Supreme Court cancelling the presidential pardon granted to the General Secretary of Bodu Bala Sena (BBS) Galagodaatte Gnanasara.

Addressing a gathering at the Sri Lanka Foundation to mark the launch of ‘Rajapaksha Samagama’ and ‘Pasku Praharaye Thoththa Babala’ by Lasantha Ruhununuge and Tharindu Uduwaragedara and M.F.M., Faseer, Viyangoda alleged that President Dissanayake’s government was also acting in a manner partial to Gnanasara Thera, the way all previous governments had done.

The NPP should be ashamed of its pathetic failure to act swiftly and decisively, immediately after the Supreme Court revoked President Maithripala Sirisena’s pardon. Viyangoda said that the government owed an explanation as to why law enforcement authorities couldn’t apprehend Gnanasara, following the announcement made on 14 Sept. “For two weeks what were they doing,” he asked.

Ven. Gnanasara was sentenced, in 2018, for a six-year period for contempt of court and intimidating Sandya Eknaligoda, the wife of Prageeth Eknaligoda who disappeared in 2010. But, President Sirisena pardoned him before the convicted monk completed one year of his six-year term.

Viyangoda said that Ven. Gnanasara had openly moved about freely, launched a book and acted as if the Supreme Court ruling didn’t have any impact. Every minute Gnanasara stayed in the open it was an affront to the Supreme Court, Viyangoda said, accusing the government of shielding a wrongdoer.

Referring to certain incidents during the Yahapalana time, Viyangoda revealed that he personally sought the then Prime Minister Ranil Wickremesinghe’s direct intervention to have Ven. Gnanasara, hiding at a faraway temple, apprehended. “I met Wickremesinghe at Temple Trees. When I raised the failure on the part of police to apprehend Gnanasara, Wickremasinghe immediately called Sagala Ratnayake, who was in charge of public security at that time. Ratnayake promised to take the monk to custody the following day. The next day, Gnanasara surrendered through a lawyer.”

Viyangoda alleged that the Wickremesinghe government had shielded Vem. Gnanasara. The Wickremesinghe-Sagala Ratnayaka duo did that in style, he said, accusing the present government, too, of doing the same.

The Court of Appeal yesterday (29) issued a warrant for the arrest of Gnanasara Thera and ordered that he be produced before the court on 1 Oct.

The court further directed that the warrant be executed through the Inspector General of Police.

This happened when a motion filed by the Attorney General, seeking an order to enforce the prison sentence imposed on Gnanasara Thera, was taken up before the Court of Appeal.

The motion was heard before a Court of Appeal bench, comprising Justices Mayadunne Corea and Lakmali Karunanayake.

President’s Counsel Anura Meddegoda, appearing for Gnanasara Thera, told the court that his client was resting due to illness and requested a date to study the motion and make submissions.

But State Counsel Sajith Bandara declared that the matter concerned a criminal case and requested that the court issue a warrant if the accused failed to appear before the court.

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More cops than cones

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Colombo’s bus priority lane rule returned today, 29 September, as a pilot programme across the city and nearby areas. It applies from 6 a.m. to 9 a.m. and from 4 p.m. to 7 p.m. daily. The renewed operation covers seven designated lanes, meant to cut delays and make public transport more predictable.

Transport Minister Bimal Rathnayake said officials would monitor the trial to assess its effect on congestion and public transport efficiency. Police have told all officers to take legal action against violators. Drivers may enter a lane only in unavoidable cases, such as emergencies, exceptionally heavy traffic, or to cross it when turning.

The Lanka Private Bus Owners’ Association has welcomed the move, and Metro Bus is adding five new routes.

The rule has been revived before, and past efforts struggled with enforcement, so the pilot project’s results will matter.

(Image courtesy Hiru)

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Sajith accuses govt. of using data selectively in crucial report

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Sajith Premadasa

Opposition Leader Sajith Premadasa has said the government is attempting to paint a falsely beautiful picture of the country’s situation through the Socio-Economic Data report issued together with the Census and Statistics and the Central Bank. “They have selectively included certain information while intentionally omitting other vital facts,” Premadasa has said in a media statement. When presenting data, there must be chronological consistency and integrity. The Central Bank and the Department of Census and Statistics have no right to present outdated data to formulate a conclusion, thereby marginalising an entire segment of the population, Premadasa has argued, pointing out that their primary duty is to report accurate information to the public.

Premadasa says that up to page 18 of the report, recent data from 2023 to 2025 have been used. For main economic indicators, macroeconomic indicators, demographic data, and life expectancy, 2024 data have been used. Indicators such as external trade finance, consumer price indices, Real GDP, imports and exports, prosperity indices, and human development indices have also been compared with Asian and SAARC countries using recent data. However, for the section detailing socio-economic conditions from page 19 to page 34, the data used are exclusively from the outdated 2016–2019 period.

When discussing socio-economic conditions, the data used for household income and expenditure surveys, provincial-level conditions, housing facilities, energy consumption, cooking, and population distribution are entirely from 2016 to 2019, the Opposition Leader has said. Specifically, the data on poverty mentioned on page 33, and even the data on per capita daily food consumption capacity on page 34, belong to this old 2016–2019 timeframe. Formulating a report for the year 2026 using such outdated data is a deliberate attempt to mislead the country and its people.

Premadasa says that from page 35 onwards, fresh 2025 data have been used for sections on prosperity, demographics, the labour force, and employment. Recent data based on current market conditions have also been provided for Gross National Income (GNI) by industrial sources, food prices, imports and exports, tourism, government revenue, state debt, and interest rates.

“If the authorities can present recent data (for 2023, 2024, and 2025) for foreign debt, financial activities, financial sector trends, and money supply, why are they using 2016 and 2019 data for poverty to mislead the country?” the Opposition Leader has asked, pointing out that the main report and its summary prove that while the government uses updated data for macroeconomic aspects, it uses obsolete data regarding poverty, inequality, income distribution, and living standards. The Opposition Leader has called this a historic deception regarding the country’s poverty, asking whether the 12.11.2026 Budget will be on these false data?

Premadasa has said that the government claims that a person can survive for 30 days on Rs. 17,315, which is an absolute lie and a deception. “This Government lacks updated data or definitions for poverty. Since the country went bankrupt, a proper household income and expenditure survey has not been conducted, nor has the poverty line been accurately identified.” He questioned whether the upcoming budget, scheduled for 12.11.2026, will be based on these false and flawed data.

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