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Treatments for dengue: a Global Dengue Alliance to address unmet needs

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Global Dengue Alliance

The importance of developing a treatment for dengue has largely been ignored, the Dengue Alliance said in a statement.However, a recently formed Global Dengue Alliance with several institutions in dengue-endemic countries, plans to accelerate research and development and deliver dengue therapeutics through an inclusive partnership.

Formation of this alliance is a major step towards developing a treatment for dengue, by aggregating resources from endemic countries, and ensuring engagement, scientific leadership, clinical guidance, and political interest in these countries.

Dengue is currently the most rapidly spreading mosquito-borne viral infection in the world, with half of the world’s population at risk of becoming infected. As a result of climate change, rapid urbanisation, and widespread international travel, the incidence of dengue is rapidly increasing, overwhelming healthcare systems in many lower-income countries. Climate change has increased the burden of dengue in endemic countries and has also led to expansion of this infection to new territories in Europe and North America.

Dengue is estimated to infect approximately 390 million individuals annually, with 96 million infections being symptomatic. So far, the only strategy adopted to reduce the burden of dengue is vector control. Although techniques such as using Wolbachia bacteria to reduce dengue transmission by Aedes mosquitoes look promising, it is evident that vector control alone is unlikely to be adequate to reduce the burden of dengue.

The currently available dengue vaccines (CYD-TDV and TAK-003) have been shown to reduce hospitalisations, especially in dengue-seropositive individuals, but lack efficacy against some dengue virus serotypes. Furthermore, CYD-TDV showed a higher incidence of severe dengue in dengue-naive vaccine recipients, and both vaccines show some degree of waning immunity with time, especially in seronegative individuals. Therefore, an integrated approach that comprises vector control, use of safe and effective vaccines, and an effective treatment is needed to face the growing challenges of dengue infection.

Efforts focused on finding a treatment have been scarce, with some investigator-led clinical trials conducted, and a few performed by pharmaceutical companies. The importance of developing a treatment for dengue has largely been ignored. The Drugs for Neglected Diseases initiative, which is focused on finding novel affordable treatment solutions for neglected tropical diseases since its inception in 2003, has recently formed a Global Dengue Alliance with several institutions in dengue-endemic countries, including the Faculty of Medicine at Siriraj Hospital, Mahidol University in Thailand; the Ministry of Health in Malaysia; the Translational Health Science and Technology Institute in India; the Oswaldo Cruz Foundation in Brazil; and the Federal University of Minas Gerais in Brazil. The mission of this alliance is to accelerate research and development and deliver dengue therapeutics through an inclusive partnership.

It aims to deliver a new treatment for dengue, within five years, from repurposed drugs and combinations (including novel antivirals from pharmaceutical companies). This alliance is co-created, co-owned, and co-funded by dengue-endemic countries, with a tiered governance mechanism allowing collaborative decision making at different levels. The organisations have formed a preclinical working group, a clinical working group, and a translational working group for effective communication and scientific planning.

All three working groups feed into the Joint Steering Committee, which is responsible for delivering on the vision and mission of the alliance. The partners of this alliance share knowledge, experience, technologies, and capabilities to jointly validate preclinical assays with the ambition in the initial phase to identify currently available drugs that can be repurposed for use as dengue therapeutics. In parallel, clinical trials for these drug candidates are being designed using the expertise of clinicians in these countries who have been treating patients with dengue for many years, with initiation planned by the end of 2023.

Formation of this alliance is a major step towards developing a treatment for dengue, by aggregating resources from endemic countries, and ensuring engagement, scientific leadership, clinical guidance, and political interest in these countries.

The different working groups and the steering committee coordinate efforts to address gaps in knowledge, such as epidemiology (specifically in Africa), biomarkers and diagnostics, clinical trials, and regulatory framework, while promoting open science. Although currently the alliance has a small number of partners, it is open to collaborations with new partners and key stakeholders in therapeutics and diagnostics.

Working with and aligning many partners and stakeholders to deliver objectives in a new model of collaboration is challenging, as is filling the existing knowledge gaps and need for integration, and leveraging information from different geographies and epidemiological settings. Furthermore, doing clinical trials aimed at treating dengue disease is challenging due to the seasonal nature of the disease, and with climate change, disease patterns could become more unpredictable.

Although this approach is likely to accelerate development of a treatment, funding remains a challenge. With climate change becoming more of a concern in high-income countries, there is an increasing possibility that many global funding organisations will acknowledge the true burden of dengue, the devastation it causes to health systems and patients in endemic countries, and, therefore, the importance of funding initiatives to accelerate the development of new treatments for dengue.



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Only single MP refuses salary as Parliament details pays and allowances

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SJB Badulla District MP Nayana Wasalathilake is the only MP to forego salary and allowances, with all payments suspended following his written notification on August 20, 2025.

Only one Member of Parliament has chosen not to receive the salaries and allowances entitled to MPs, Prime Minister Dr. Harini Amarasuriya revealed in Parliament last Thursday, shedding light on the financial perks enjoyed by members of the Tenth Parliament.

Speaking on Thursday (Feb. 19) in response to a question from SJB Badulla District MP Chaminda Wijesiri, the Prime Minister outlined the full range of pay and allowances provided to parliamentarians.

According to Dr. Amarasuriya, MPs receive a monthly allowance of Rs. 54,285, an entertainment allowance of Rs. 1,000, and a driver’s allowance of Rs. 3,500—though MPs provided with a driver through the Ministry of Public Security and Parliamentary Affairs are not eligible for the driver’s allowance.

Additional benefits include a telephone allowance of Rs. 50,000, a transport allowance of Rs. 15,000, and an office allowance of Rs. 100,000. MPs are also paid a daily sitting allowance of Rs. 2,500 for attending parliamentary sessions, with an additional Rs. 2,500 per day for participation in parliamentary sittings and Rs. 2,500 per day as a committee allowance.

Committee meetings held on non-parliament sitting days also attract Rs. 2,500 per day.

Fuel allowances are provided based on the distance between an MP’s electoral district and Parliament. National List MPs are entitled to a monthly allocation equivalent to 419.76 litres of diesel at the market price on the first day of each month.

Despite the comprehensive benefits, only SJB Badulla District MP Nayana Wasalathilaka has opted not to draw a salary or allowances. Dr. Amarasuriya said that in accordance with a written notification submitted by MP Wasalathilaka on August 20, 2025, payments have been suspended since that date.

The Prime Minister also confirmed that she, along with the Speaker, Deputy Speaker, committee chairs, ministers, deputy ministers, the Opposition Leader, and senior opposition whips, have all informed the Secretary-General of Parliament in writing that they will not claim the fuel allowance.

Challenging the ruling party’s voluntary pledge to forgo salaries, MP Wijesiri pointed out that all MPs except Wasalathilaka continue to receive their salaries and allowances. “On one hand you speak about the people’s mandate, which is good. But the mandate also included people who said they would voluntarily serve in this Parliament without salaries. Today we have been able to prove, Hon. Speaker, that except for one SJB MP, the other 224 Members are drawing parliamentary salaries,” he said.

The Prime Minister responded by defending the political culture and practice of allocating portions of MPs’ salaries to party funds. Referring to previous practices by the JVP and NPP, she said: “It is no secret to the country that the JVP has for a long time not personally taken MPs’ salaries or any allowances. I think the entire country knows that these go to a party fund. That is not new, nor is it something special to mention. The NPP operates in the same way. That too is not new; it is the culture of our political movement.”

When MP Wijesiri posed a supplementary question asking whether diverting salaries to party funds was an indirect method of taking care of MPs, Dr. Amarasuriya said: “There is no issue there. No question was raised; the Member made a statement. What we have seen throughout this week is an inability to understand our political culture and practice, and a clash with decisions taken by political movements that misused public funds. What is coming out is a certain mindset. That is why there is such an effort to find fault with the 159. None of these facts are new to people. He did not ask a question, so I have nothing to answer.”

The disclosures come days after the Government moved to abolish the parliamentary pension, a measure that has sparked renewed debate over MP compensation and the transparency of funds allocation.

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Illegal assets of underworld figures frozen since September, Minister tells parliament

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Wijepala

Public Security and Parliamentary Affairs Minister Ananda Wijepala on Friday (20) disclosed in Parliament details of properties and assets allegedly acquired through illegal activities by suspects arrested in raids carried out since September last year.

The Minister made the disclosure in response to a question raised by MP Ravindra Bandara, stating that the identified assets have been frozen pending further investigations.

He said the assets include properties belonging to several alleged organised crime figures, among them Mandinu Padmasiri, alias ‘Kehelbaddara Padme’, who was arrested last year.

Listing the assets in the House, the Minister said Hapugoda Arachchige Kankanamge Duminda Dilruk has assets worth Rs. 23 million frozen, including a van, a motorcycle, a house and a roller gate.

In the case of Kandaiya Kalamogan, two motorboats have been identified, although their value has not yet been assessed.

Dilum Tharaka Balasuriya is reported to own a two-storey house situated on 15 perches of land with a face value of Rs. 800,000.

Assets belonging to Mohammad Harish Mohammad and Mohammad Shiyam were frozen on January 21, 2026. While the total value has not yet been assessed, five vehicles were confiscated from the former and a car from the latter.

Wijesuriya Mahaduruge Uditha Iroshan Wijesiri has assets valued at Rs. 5 million, including a lorry, while Indika Pathmakumara’s assets include a cab worth Rs. 2.5 million and a bank account containing Rs. 1 million.

Lahiru Sampath is reported to own a three-wheeler valued at Rs. 1.8 million.

According to the Minister, Hettiarachchige Dona Sriyani Chandralatha possesses a four-storey house and 14.7 perches of land valued at Rs. 60 million.

Mandinu Padmasiri, alias ‘Kehelbaddara Padme’, owns 20 perches of land with partially constructed buildings valued at Rs. 30 million and a half-finished six-room building worth Rs. 20 million, the Minister said.

Patabendi Maddumage Shehan Sathsara, alias ‘Dehi Bale Malli’, has five multi-day fishing trawlers valued at Rs. 200 million and a two-storey house with 15.8 perches of land worth Rs. 50 million.

The Minister further disclosed that Jayasinghege Maduranga Sampath owns a cab worth Rs. 5.4 million, a van valued at Rs. 14.5 million, five bank accounts containing Rs. 73.03 million, another account with Rs. 160,328.88 and USD 544, and Rs. 283 million in cash.

Adhikari Samantha Perera is reported to own 10.10 perches of land valued at Rs. 5 million and one acre and 1.5 perches of land worth Rs. 13 million.The Minister said investigations are continuing in respect of the suspects and the frozen assets.

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Entire coal procurement rigged, SJB charges minister over substandard fuel

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Marikkar

The entire coal procurement process was rigged, the main Opposition SJB alleged in Parliament on Friday, accusing Energy Minister Eng. Kumara Jayakody of misleading the Cabinet and the National Procurement Committee to favour a supplier of substandard coal for the Lakvijaya Coal Power Plant in Norochcholai.

Moving an adjournment debate on the energy crisis, SJB Colombo District MP S.M. Marikkar charged that the losses incurred from the importation of inferior coal must be fully computed and recovered from those responsible, including damage caused to machinery, additional power generation costs and environmental harm.

He said the SJB had exposed the issue both inside and outside Parliament, alleging that the Government was attempting to cover up large-scale irregularities in the 2026 coal procurement process.

Marikkar claimed that serious fraud, corruption and procedural violations had taken place from the outset. He pointed out that the standard 42-day procurement period had been curtailed to 21 days, thereby restricting competition and preventing many qualified companies from participating.

He further alleged that key eligibility criteria had been diluted, including the requirement that a supplier must have imported 500,000 metric tonnes of coal over the past three years. This threshold, he said, had been reduced to 100,000 metric tonnes to enable smaller firms to qualify.

According to the MP, despite instructions issued by the Committee on Public Finance and the Auditor General regarding the procurement process, the Minister had misled the Cabinet and the National Procurement Committee to deviate from the approved procedure in order to favour a particular company that subsequently supplied substandard coal.

Marikkar alleged that the first, third and fourth shipments had contained inferior coal, which had been mixed with existing higher-quality stocks and used at the Norochcholai plant. He said the resulting losses to the power generation system would far exceed the reported US$ 2 million fine imposed on the importer.

He also highlighted alleged irregularities in the tender process, claiming that the chairman of the tender board had withdrawn after decisions were taken and had failed to attend subsequent meetings.The MP further charged that the Government was attempting to justify impending power cuts by citing a purported shortage of coal.

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