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Herd immunity and vaccination

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HERD IMMUNITY: A good analogy is protection of calves in a herd of wild buffalos from predation by leopards. A sizeable number of adult bulls and cows in the herd attack and repulse leopards. Once in a way, a leopard would succeed dragging a calf, but a large majority of calves survive to ensure the continuation of the species. (Picture courtesy HAP Channel: https://www.youtube.com/watch?v=igx_pr6ptAg&ab_channel=HAPChannel)

By Prof.Kirthi Tennakone,
National Institute of Fundamental Studies
(ktenna@yahoo.co.uk)

With the advent of coronavirus vaccines, the idea of herd immunity is gaining ground – but often misunderstood or considered something hard to fathom. Herd immunity means the resistance a community develops against an infectious disease, when a fraction of its residents above a threshold acquires immunity either by exposure to the pathogen or vaccination. Thus, achieving herd immunity could safeguard individuals who cannot be immunized for reasons of being too young, convalescent or because of inadvertent inaccessibility.

A good analogy is protection of calves in a herd of wild buffalos from predation by leopards. A sizeable number of adult bulls and cows in the herd attack and repulse leopards. Once in a way, a leopard would succeed dragging a calf, but a large majority of calves survive to ensure the continuation of the species. If leopards prey exclusively on buffalos, they might be starved into extinction. Buffalos and leopards live in the jungle because the latter also hunt other animals. Similarly, in absence of non-human reservoirs of the pathogen, herd immunity provides a way of controlling an infection causing an epidemic or a pandemic and the elimination of the causative agent.

 

History and theory of herd immunity

Epidemics originate when a pathogen invades a population devoid of immunity. Science fiction writer H.G. Wells in his novel, “The War of the Worlds”, says Martian invaders were not immune to earthly microbes and all died due to an infection. We are not so alien to viruses here and the ability to make antibody machinery to fight them are genetically imprinted in our bodies.

Even in olden days when precautionary measures remained completely unknown or misunderstood, maladies ended before everyone caught the infection. Those days, epidemics were considered divine punishments or expressions of anger of deities. The cause that receded them; attributed to prayers, rituals or offerings to the demons, has been in fact the natural herd immunity.

The Mahavamsa and the Elu Athanagalu Vamsa refer to a catastrophe during the reign of King Sri Sanga Bodhi (252-254 CE). According to the legend in the latter script; a demon named Ratharaksha came to Sri Lanka and cast a spell reddening the eyes of people who stared at it in fear. Many who looked at the eyes of those afflicted also developed red eyes and contracted the illness. Very high mortality thinned the population of the land and the distressed king, ritualistically confronted the demon driving it to exile. The version of the story in Mahavamsa is similar but implicate a female demon Ratarakshi. What is the infectious agent behind this outbreak? From the symptoms described and the extreme contagiousness implied, the illness that ravaged the kingdom seems to be measles. The herd immunity threshold of measles exceeds 95%. There was also a famine accompanying the epidemic. Presumably, malnutrition and absence of immunity greatly increased the measles death toll.

Ages ago people lived in isolated communities. Therefore, an infectious disease which decelerated and vanished after reaching herd immunity did not remerge until the immunized percentage was lowered by people born subsequently. Many epidemics, notably small pox and plague followed cyclic patterns for this reason. Later on, the establishment of vast human settlements and extensive migration, turned epidemics into pandemics and many diseases remained endemic. Historians have also argued that the consequent wider dispersion of diseases, boosted the immunity of the global human herd thereby escalating the population growth.

The idea of herd immunity was first introduced by the American veterinarian George Potter in 1917; he noted a cattle disease disappeared on its own when animals were not introduced to the herd from outside. He said disease resembled a fire which extinguished when all fuel has been consumed.

In 1919 bacteriologist W. Topley infected a few mice in a large colony with a germ. He observed the infection expanded, subdued and stopped after infecting only a certain percentage of mice. Further clarification of difference between individual immunity and herd immunity followed from the work of American statistician A.W. Hedrick. He studied the epidemiology of measles in United States 1900-1911 and concluded measles epidemics ceased when 68% of children under 15 years became immunised after contraction of the illness.

The idea of herd immunity was firmly established after invoking mathematics into epidemiology – mathematician turned physician Sir Ronald Ross pioneered the theme.

Ronald Ross, born in India 1857, received his education in the United Kingdom and returned to his country of birth after qualifying as a doctor. He joined the Indian Medical Service 1880 and worked in Bangalore badly infested with mosquitoes. At the time malaria was suspected to be associated with mosquitoes. Curious, Ronald strived hard to understand how it was transmitted. Mosquitoes in the place he lived has been a nuisance; he closed all stagnant pools in the vicinity of his residence and found the mosquito number falling drastically, but realized complete elimination would be an impossibility. When Ronald Ross was transferred to a station free of malaria, he declined to work in a locality free of malaria!

In 1895, Ronald Ross identified the malarial parasite in stomach of anopheles mosquitoes proving its mode of transmission. He was awarded 1902 Nobel Prize in Physiology for this work done in India.

Having found the cause of malaria; Ronald Ross determined to find a way to eradicate it and resorted to mathematics in attempting to find an answer. His remarkably insightful mathematical analysis revealed malaria could be eradicated by reducing the mosquito population below a threshold dependent on human population density, and the impossible task of destroying every anopheles mosquito was unnecessary. Following work of Ronald Ross, another physician A.G. Kendrick and biochemist W.O. Karnack both well versed in mathematics generalized Ronald Ross’s hypothesis, concluding the progress of infectious disease in a community depends on the average number of infected persons reproduced by one single carrier of the pathogen. If this number referred to as basic reproduction number (R) exceeds unity, the infection could expand into an epidemic whereas when the number is less than one the disease subsides after infecting a few. From statistics pertaining to the growth of an infection, the basic reproduction number can be estimated.

It is easy to see how an infection evolves depending on whether R is greater or less than one. Suppose 10 persons contracted with an infection with R=2 enters a susceptible population. On average, they pass sickness to 20 individuals and this 20 in return reproduce 40 cases – an endless series of ascending numbers. If R is less than one you obtain a descending sequence – implying cases die down.

 

Herd immunity threshold

Suppose a population of N persons includes a number M of individuals immune to a disease. The fraction of immunes in the population is M/N (M divided by N). From simple school arithmetic, it follows that the fraction of persons not immune (susceptible) is (1- M/N). In the presence of immunes, the basic reproduction number scale down proportionately to the fraction of the susceptible population so that the effective reproduction number is (1 –M/N) times R, written as (1-M/N) R. The threshold happens when the effective reproduction number is exactly equal to unity, implying (1 –M/N) R = 1 or equivalently M/N = 1 – 1/R. The fraction M/N given by the above formula, referred to as herd immunity threshold is normally expressed as a percentage. For example, measles being highly contagious, the basic reproduction number can take values close to 20. Setting R = 20 in the formula, we obtain M/N = 0.95. Expressed as a percentage, the herd immunity threshold for measles is 95. To protect a community against measles, over 95 percent of the population needs to be vaccinated.

Vaccinating a community to exceed the herd immunity threshold would not abruptly halt an epidemic. Although the incidence of the disease gradually decreases, vaccinations and containment measures have to be continued until positive cases disappear completely – smallpox was eradicated this way.

 

Can we achieve herd immunity to COVID-19?

Coronavirus vaccines have arrived sooner than expected – many countries including Sri Lanka expeditiously commissioning inoculation campaigns.

Vaccinations and continuous adherence to precautionary measures will undoubtedly tame the virus. However, it is premature to assume global herd immunity would follow and the pandemic will soon end.

According to some estimates an upper bound to basic reproduction number for COVID -19 is around 2.5. Formula M/N = 1- 1/R explained previously, imply that the herd immunity threshold corresponding to R = 2.5 is 60 percent. Vaccines may not be 100 percent efficacious. For an 80 percent effective vaccine, the above thresholds increase to 75 percent. The other question is how long the vaccine induced immunity would last. At the moment sufficient information is not available to decide how the duration of immunity will interfere with the herd immunity threshold and how often vaccinations need to be repeated.

If faster spreading variants of the virus take over, the basic reproduction number and therefore the herd immunity threshold will also increase. The variants may turn out to be more resistant to vaccines. Remodeling of vaccines to make them effective towards variants is technically feasible but would delay the immunisation protocols. The answer to the problem of variants and temporary immunity is speedy vaccination – obviously constrained by real world practicalities.

 

Decreasing trends of COVID -19 incidence

Many regions of the world have begun to see a decline in the number of COVID-19 cases and deaths – plausibly a combined outcome of preventive safeguards and immunity derived from exposure to the virus or vaccination.

Israel has given more coronavirus vaccinations per capita than any other country – around 50 percent given one dose and 35 percent both doses. Covid-19 cases are declining and the world is awaiting see the outcome of the Israel experiment.

The United Kingdom has vaccinated more than 30 percent of over 80s and noticed a dramatic reduction in COVID-19 related deaths in this group.

Prompt inoculation of a sizeable fraction of a community is not an easy task. We need to await patiently to see the effectuality of the vaccines.

Dependence of herd immunity threshold on preventive measures

The preventive strategies or so-called non-pharmacological interventions significantly reduce viral transmission thereby lowering basic reproduction number and therefore the herd immunity threshold. Wearing masks, social distancing, hand-sanitizing and ventilation are proven safeguards. There is some evidence and theoretical arguments to the effect that preventive measures not only reduce the risk of contracting the disease but those who catch the disease under such circumstances develop milder symptoms or recover soon, adding to the pool of immunes. Argument rest on inoculum theory of viral transmission, according which the intensity of the infection a patient develops depends on the number of virus particles to which he or she was exposed. Emphasizing this point authors of a recent article published in the prestigious medical journal Lancet appeal to the world to continue strict adherence to preventive measures. This is most prudent method to safeguard against new strains until vaccines are remodeled.

Vaccination priorities

Vaccine production, procurement and organization of immunization campaigns decide the rate at which a community could be vaccinated. These limitations necessitate imposition of priorities. The World Health Organization and individual nations have laid down priority categories. Everyone agree the first priority should be frontline health care workers. The second category the older persons (generally above 65) more vulnerable and at the risk of death after contracting the sickness. Those living under conditions of extreme congestion and poverty are also a priority group identified by WHO. The younger working class, although they are less susceptible to danger of COVID-19, needs to be vaccinated. The policy of neglecting the older group in favour of younger working class is not only unethical but also epidemiologically flawed. In modern societies the percentage older persons (above 65) and socially active are significant. They, being most vulnerable to contracting the sickness because of impaired immunity, if infected, could also be the super spreaders. Recent studies have confirmed the presence of super spreaders, who are mostly elderly patients carrying larger viral loads.

Social reaction to vaccination

Societies react to vaccinations within confines of two extremes: vaccine hesitancy and vaccine overconfidence. The former has prevented eradication measles in localities where the herd immunity threshold stands inordinately high. In some parts of the world, vaccine hesitancy confuses mass COVID-19 inoculation. The latter misconception equally undermines the control effort. Not wearing a mask or not adhering to social distancing because you got the jab is not right. Vaccines are not 100 percent effective and immunity sometimes slacken. People not wearing masks, believing assurance of safety after the jab creates social stigma for those not vaccinated to abandon the precautions.

Vaccines and non-pharmacological interventions will certainly suppress the virus. Rapid decline in reported cases in some parts of the world may be a sign of a distant herd immunity in that region – but what we want is a global effect. As WHO Director Tedros said, “Until we end the pandemic everywhere, we will not end it anywhere “



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Features

Trump’s tariffs, AKD’s gazette and Sri Lanka’s diplomatic slumber

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“We are rather respectable in Colombo. We go to bed fairly early, and we remain there till morning. “

According to Sri Lanka’s diplomatic folklore, the late S.W. R. D. Bandaranaike uttered these words while explaining the reasons for Sri Lanka’s abstention on the UN resolution condemning the Soviet invasion of Hungary. Apparently, SWRD’s foreign ministry officials were asleep at home when the diplomatic cable seeking instructions was received from New York. In those days, there were no cell phones, Internet, or even fax or telex machines. The diplomatic cables were sent through post offices. Decoding them was a slow and time-consuming process. Thus, the government could not provide appropriate instructions to our mission in New York in time, and the Sri Lankan delegation abstained on that sensitive UN vote.

Sri Lanka’s Absence from Section 301 Consultations

But then, how does one explain Sri Lanka’s absence from the crucial bilateral consultation held in Washington by the Office of the United States Trade Representative (USTR) during March-April on “Forced Labour” under the Section 301 of the US Trade Act of 1974? Didn’t our foreign and trade ministries send appropriate instructions to Washington in time? Even if the instructions from the foreign ministry were transmitted to our embassy in Washington by pigeon carriers, there was enough time for Sri Lanka to participate in those meetings.

In March, the USTR initiated these 301 investigations on 60 trading partners, and invited all of them for confidential consultations. Out of the 60, 46 participated in these consultations. Sri Lanka was not one of them. Other countries that didn’t participate in these consultations included China, Russia, and Venezuela! In addition to that, the Section 301 Committee conducted a public hearing with interested parties on April 28 and 29. Washington-based diplomats, representatives from few trade ministries as well as representatives from many foreign trade associations and chambers participated in these hearings. Sri Lanka was once again conspicuously absent.

As a result, when the USTR published the proposed forced labour tariffs on June 2nd, Sri Lanka ended up with a 12.5% duty. Pakistani and Indonesian diplomats participated in these consultations and took appropriate follow-up measures, and managed to enter the 10% duty category. As even a threat of a modest tariff hike could disrupt supply chains and reduce competitiveness, particularly in an industry such as garments, I discussed this issue on 15 June and underscored the importance of Sri Lanka’s participation at the next hearing, which was scheduled to be held from July 7th .

Awakening from Diplomatic Slumber and AKD’s Gazette

Fortunately, Sri Lanka finally awoke from weeks of diplomatic slumber, and Ambassador Mahinda Samarasinghe participated in the public hearing on 9 July, and promised, “…. · We have agreed to the text in our negotiations with the USTR on forced labour, …. The gazette as we speak is being printed and I’m getting the gazette tomorrow morning, and the gazette will be shared with USTR as I get it“.

As promised, President Anura Kumara Dissanayake issued a gazette on 10 July banning the imports of goods produced by forced labour. These new regulations are very similar to what Pakistan and Indonesia enacted in April, after their consultations with USTR in March. Why couldn’t we do it in April? Why did we wait till the very last minute?

Challenges ahead

“War is too important to be left to generals alone,” is a famous saying attributed to former French Premier Georges Clemenceau. Similarly, monitoring our main markets is too important to be left to diplomats alone. The United States is the largest single-country market for Sri Lanka. Therefore, Sri Lankan trade chambers and associations should become more proactive in these markets and participate in these events. For example, the chairman of the Pakistani apparel exporters association participated in the April hearings. Similarly, representatives from the Indian Agricultural and Processed Food Products Export Development Authority, the Federation of Indian Chambers of Commerce and Industry, the Confederation of Indian Industry, and Reliance Industries also participated in July hearings. At an event where each speaker is given only five minutes (strictly enforced), having a number of speakers from a country is an advantage. The presence of industry representatives in these kinds of events also help them understand the market dynamics and the future challenges. This is important, particularly because there will be many more challenges with Trump’s tariffs.

With the gazette issued on 10 July, Sri Lanka has imposed a prohibition on the importation of goods produced with forced labour. Now, the challenge will be to effectively enforce the prohibition. And what are the goods produced with forced labour? The USTR list only focuses on aluminum, cotton, electronics, lithium-ion batteries, rice, and tobacco. However, according to the U.S. Department of Labour, the list is much longer. Hence, this list may change continuously during the next two years and tariffs may fluctuate once again.

So, this is definitely not the time to slumber.

(The writer, a retired public servant, can be reached at senadhiragomi@gmail.com)

by Gomi Senadhira ✍️

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Tales of Mystery and Suspense 10 Casino for Sale

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After the overwhelming grotesquerie of J K Rowling’s latest Cormoran Strike novel (written, I should have noted, as the others were, under the pseudonym Robert Galbraith), I thought I should return to the world of fun, and also a much shorter description since this thriller moves quickly without the layers of detail that Rowling engages in.

I then move to the second comic thriller by Caryl Brahms and S J Simon. This, their second story to feature Vladimir Stroganoff and Adam Quill, was Casino for Sale, as lunatic a romp as the first, though without the emphasis on the ballet that characterized A Bullet in the Ballet.

This one begins with the impresario Stroganoff buying a casino cheap from Baron Sam de Rabinovich, only to find that it was a rundown place, not the grand casino of La Bazouche, a resort on the Frenc+h Riviera, as he had initially thought. The grand one belonged to Lord Buttonhooke, and Stroganoff could  not compete, until he thought of bringing the Ballet Stroganoff to the casino – which of course leads to Buttonhooke deciding to have ballet performances in his Casino too.

Stroganoff invites Quill to visit him, which Quill decides to do since he has left Scotland Yard, having come into a legacy. No one believes this, and he has to face questions as to what he did to have been sacked, with sympathy for having been found out.

Caryl and Simon

The day he arrives in La Bazouche there is a murder, of a vitriolic critic called Citrolo, in Stroganoff’s office. He had been going to write a damning review of the opening night of the ballet and Stroganoff, when he realizes Citrolo cannot be swayed, drugs him and dictates the review himself to the papers. He leaves Citrolo sleeping and finds him shot the next morning, whereupon he decides to muddy the waters and leave a suicide note and lots of other murder weapons. So much overkill, as it were, of course ensures that he is arrested.

But the excitable French detective who makes the arrest follows up his suggestion that Buttonhooke was also involved, and so the two casino owners find themselves in cells next door to each other, with the detective Gustave quite happy to provide creature comforts for a fee.

Quill decides he must investigate, and finds Gustave most cooperative, since he has a laid back attitude to work. So it is Quill that finds a notebook which makes it clear Citrolo is an accomplished blackmailer, and that there are lots of possible murderers, including Stroganoff’s croupier, who was crooked, Rabinovich, who was now working for Buttonhooke, a confidence trickster called Kurt Kukumber, whose prospectus for a dud gold mine was found in the office and Prince Alexis Artishok who was engaged in a deal to buy diamonds from the ballerina Dyra Dyrakova.

Stroganoff had been trying to get Dyrakova to dance for him, but having done so previously she had refused. But then to Stroganoff’s chagrin she agreed to dance for Buttonhooke. The clearly crooked Artishok had told Buttonhooke’s mistress Sadie Souse, who was not very bright, that Dyrakova possessed diamonds she was willing to sell cheap, and Sadie was determined to have them.

Quill meanwhile finds out that there was a secret passage to Stroganoff’s office, the obvious solution to what had begun as a locked room mystery, and that this was known by almost everyone apart from Stroganoff himself. And then Rabinovich is murdered, just after Gustave had released his two original suspects, leading him to blame Quill for having insisted on that and thus allowing them to kill again.

Soon afterwards Dyrakova arrives, and the town is full of posters announcing that she will appear in the casinos, elaborate posters for either one, since Stroganoff is determined that she will dance for him, and if she does not come willingly, he has devised a scheme to make her do so unwillingly. So, though Buttonhooke has her taken off to his yacht immediately she arrives at the station, Quill along with Arenskaya gets her into a launch and to Stroganoff’s casino, where she performs to tumultuous applause, not knowing for whom she is dancing.

When Quill asked her about the diamonds, she said she had sold them long ago, and that gave Quill the solution to the mystery. Rabinovich had known about this, and Artishok had killed him to prevent Sadie learning it from him, he had killed Citrolo who had recognized him for an accomplished card sharper, not a Russian prince at all. But before he is arrested, he gets away in a boat, and the police launch that pursues him is on the point of catching him up when it runs out of petrol.

Again, lots of excitement, and entertaining references  – Gustave grows marrows – and if not quite as brilliant as its predecessor, Casino was certainly a delightful read.

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The challenge of being positive about SAARC

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The RCSS forum addressed by SAARC Secretary General Ambassador Md. Golam Sarwar in progress. (Pic courtesy RCSS)

It was a few years back that a former President of Sri Lanka took it on himself to pronounce SAARC ‘dead’. Since then there have been other sections of Sri Lankan opinion that have joined the critics of SAARC and taken the solemn stance that SAARC has indeed died what may be called a natural death.

Their fatalism is understandable. SAARC has failed to meet at heads of government or state level for the past several years to take the SAARC process notably forward. Regional cooperation has more or less been only an appealing idea. No substantive concrete projects have taken off to make the idea a hard reality. ‘Inner paralysis’ seems to be SAARC’s lot. Hence the fatalism in these circles.

However, being one of the worst cash-strapped regions of the world and a teemingly populated one with people virtually left to their devices, what choices do the ‘SAARC Eight’ have other than to try their best to band together and continue with their cooperation efforts, however small they may be?

There is no escaping the mounting debt trap for many of these countries and bankrupt Sri Lanka is a glaring example, but ‘throwing in the towel’ and abandoning themselves entirely to the diktats of the strongest economies and their agencies will prove a ‘living death’ for many countries in the SAARC fold.

The gains may be meagre but giving-up on SAARC cooperation in full would prove self-defeating for the organization and South Asia. Right now, the collective intention ought to be to salvage what the region could from the tenuous cooperative efforts. Moreover, such initiatives could go some distance to generate a degree of goodwill among the Eight and help in sustaining a dialogue process.

Given this backdrop it proved ‘a stich in time’ for the Regional Centre for Strategic Studies (RCSS), Colombo, to recently host the SAARC Secretary General Ambassador Md. Golam Sarwar to a round table discussion on the unifying potential of SAARC and its future possibilities, besides other related issue areas.

Held on June 24th and moderated by RCSS Executive Director and former ambassador Ravinatha Aryasinha, the forum brought together a vibrant, wide ranging audience comprising academicians, diplomats, senior public servants, civil society activists and many others. Following the presentation by Ambassador Golam Sarwar titled, ‘Reigniting SAARC: Achievements, Challenges and the Way Ahead’, a lively Q&A followed.

The above forum could be described as an act of lighting the proverbial ‘candle’ rather than ‘cursing the darkness.’ It surely is a ‘darkness’ that could be seen as daunting considering that the region’s pivotal powers, India and Pakistan, are failing to act in a spirit of accord but are engaged in bitter finger-pointing on a number of questions of vital importance to SAARC.

On the other hand, what is the rest of the region doing to bring the above sides together? It is disappointing that to date the rest of SAARC has failed to launch a major diplomatic drive to bring peace between the feuding regional heavyweights. It needs to act without delay and establish its earnestness and this effort would need to prove SAARC’s staying power in the unfolding months and even years.

In assessing SAARC’s seeming failure local opinion in particular has failed to factor in what could be described as weak leadership. Since Sheikh Mujibur Rahman of Bangladesh, the founding father of SAARC, the region has failed to produce a visionary leader who could advance the SAARC cause with charisma and drive.

Among other reasons, weak leadership accounts considerably for the faltering and stuttering status, as it were, of SAARC. Badly needed are leaders who could go the extra mile, think less of narrow national interests and work diligently towards the collective well being of the region but SAARC’s millions of ordinary people have been made to wait in vain for leaders of such stature. Instead, they have been burdened with politicians who seem to be relishing the apparently moribund state of SAARC.

Looking back, it could be said that it was the dynamic leadership factor that led to the launching of the Non-Aligned Movement and for its sustenance for a few decades. True, it could be seen in some quarters that NAM is no more, but as in the case of SAARC, the former too has been unfortunate to be burdened over the years with politicians who lack the vision and drive to unflaggingly advance the fortunes of the South. NAM and SAARC lack the dynamism and vision of leaders of the stature of Jawaharlal Nehru, for example, to give them the required guidance and intellectual depth.

The reasons are complex for there not being among us currently political leaders with the vision and the steadfast commitment to advance the legitimate interests of the South. However, it could be stated with conviction that the majority of Southern leaders have too easily caved in to the demands of the global North and its financial agencies.

These leaders have failed to see, for instance, that the largely market economy oriented Northern governments would not view with favour a centrist economic model that attaches priority to the interests of the dis-empowered publics of the South. This realization ought to have dawned on the current government in Sri Lanka, for instance, some while ago but it has no choice but to abide by IMF dictates since economic survival at present is unthinkable without the latter’s succour.

Accordingly for SAARC this should be the time for some soul-searching. Priority needs to be attached to ending the feuding between India and Pakistan since at present the material fortunes of the region hinge largely on these regional giants giving peaceful relations among them a try. This is no easy challenge to meet but some daring, visionary diplomacy needs to take hold among the rest of SAARC.

There is some sense in SAARC bringing the peoples of the region together through programs that address their best collective interests. A meeting of minds among SAARC nations could enable SAARC and its agencies to build a region-wide people’s movement for progressive political and economic change that could in turn lead to the region’s political leaders sensitizing themselves more to the neglected needs of their publics.

However, the time is ‘now’ for the initiation of these progressive changes and the voice of SAARC well wishers would need to drown out those of their critics.

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