Features
Discovery of molecular structure of primary genetic material of life
World DNA Day falls on 25 April:
On 25 April 1953, Watson and Crick published an article, in the acclaimed journal “Nature” titled “Molecular structure of nucleic acids: A structure for deoxyribonucleic acid”.
The one-page article largely based on theoretical arguments and the previous work of Rosalind Franklin who examined DNA using X-rays, changed the world forever by explaining how genetic information is copied and transmitted.
Everyone concerned with promoting science in the country should be aware of the story behind the discovery of DNA and tell it to their children and students and remind the policymakers.
The world commemorates the transformative event on 25th April every year. An example vividly illustrates how intense curiosity and imagination, rather than mere indulgence in technologies, leads to groundbreaking discoveries.
DNA Day is also intended to celebrate the completion of the Human Genome Project in 2003. Genome means the entire set of genetic information characterising an organism.
Heredity and inheritance
Heredity is the cause of transferring traits from parents to their offspring. The closely related word “inheritance “refers to the specific nature of the transmitted trait. For example, we say intelligence is hereditary in their family and he inherited his father’s intelligence.
The resemblance of progeny to parentage was common knowledge, taken for granted and considered a blending of maternal and paternal traits. Philosophers of antiquity proposed several theories to explain the inheritance of parental traits by the offspring. Hippocrates believed the essence of all body parts of the parents are incorporated into the male and female germinal essence and therefore the offspring display characteristics as a proportionate blend. Aristotle offered a different explanation. He argued that the active principle is in the male seminal fluid and the mother’s blood provided the original body material. The inaccuracy of these theories was apparent. Sometimes children possess qualities akin to grandparents rather than parents. Fathers or mothers of humans and animals, deformed by accidents or disease, gave birth to normal children- a clear proof that the acquired characters are not inherited. Children of a blue-eyed mother and a brown-eyed father have either blue or brown eyes but not a blend of blue and brown.
Two golden sayings in our culture, “Arae gathi nare” and “Jammeta wada lokuei purrudha” (“Hereditary characters persist” and “Habits overtake heredity “), agree more with modern genetics, than the views of Hippocrates and Aristotle.
Gregor Mendal’s groundbreaking experiment
The Austrian mathematician cum botanist, Gregor Mendel was the first to conduct a systematic investigation to understand the cause of heredity. Being unconvinced of the traditional explanations, he carried out a series of experiments lasting eight years to determine how the traits (plant height, seed color, flower color etc.) of pea plants are transmitted from generation to generation. When Mendel cross pollinated tall and short plants, he found that the progeny was entirely tall. However, when first generation tall plants were allowed to self-pollinate, the missing short trait reappeared at a statistically significant probability of 25 percent. Mendel’s work provided an unequivocal proof that traits do not blend but exist as unique entities, manifested from generation to generation following a predictable mathematical pattern.
Mendel’s finding remained unrecognized for more than 30 years. His ideas were too far ahead of time and biologists were shy of mathematics. In the early 1900s several European botanists arrived at the same conclusion based on independent experiments. With the advancement of microscopy, a great deal of information about plant and animal cells was gathered. A key finding was the presence of colored bodies in the cell nucleus named chromosomes, seen separating during cell division, leading to the hypothesis that Mendel’s genetic units (genes) should be physical entities present in the chromosomes.
Chemists and biologists wondered what the genetic material in chromosomes made off. Is it a protein, carbohydrate or a lipid? Most biological materials are constituted of these substances.
Discovery of DNA
Great discoveries are made by unusual people. The Swiss Friedrich Miescher belonged to a clan of reputed physicians. Following family tradition, he qualified as a doctor but did not engage in profitable practice of medicine. He decided to do research to understand the foundations of life. In search for new biological substances, he experimented with pus deposited in bandages and extracted a substance rich in phosphates but very different from proteins. The new substance called “nuclein” was indeed DNA. Later, the German biochemist Albrecht Kossel following the Miescher’s work, showed that DNA contains four crucial compounds, adenine (A), cytosine (C), guanine (G) and thymine (T), known as nucleotide bases.
Avery – MacLeod – McCarthy Experiment
The flu pandemic of 1918 killed an estimated 50 million people worldwide due to the pneumonia that followed the viral infection. Pneumonia was caused by the virulent bacterium Streptococcus pneumoniae. The British bacteriologist, Frederick Griffith attempting to find a vaccine for pneumonia, worked with two strains of Streptococcus pneumoniae, one virulent causing pneumonia in mice, and the other avirulent to them. He found that neither the virulent strain denatured by heating nor the live avirulent strain injected into mice caused the disease, whereas a mixture of the denatured virulent strain and the live avirulent strain was deadly to mice just as the virulent one. He concluded that some chemical compound present in the virulent strain – a transforming principle – has changed the avirulent strain to the virulent strain.
In 1944, Oswald Avery, Colin MacLeod and Maclyn McCarty working at the Rockefeller University, United States, continued the work of Frederick Griffith to identify the transferring principle and found that it is not protein as widely believed, but deoxyribonucleic acid (DNA). Their result pointed to the conclusion that DNA is the carrier of genetic information.
A book by a physicist that triggered a transformation in biology
The insights of brilliant brains engaged in fundamental inquiry have opened the way for major scientific discoveries and technological innovations. In 1944, the Austrian theoretical physicist Erwin Schrodinger, one of the founders of quantum mechanics, published a book titled “What is life? The physical aspect of the living cell “. The American biologist Maurice Wilkins said he was so inspired by Schrodinger’s book and after reading it, he decided to switch from ornithology to genetics. While physicist Maurice was influenced to take up biology. Francis Crick was a physicist working on magnetic mines for the British Admiralty during the war. After reading “What is life” he thought a physicist could find treasures in biology and joined the Cavendish Laboratory in Cambridge to pursue a Ph.D.
Structure of the DNA molecule
When DNA was shown to be the molecular entity that encodes genetic information, chemists rushed to determine its structure.
The pattern formed when X-rays passing through a material cast an image on a screen, provides information about its molecular structure. In 1938, the English physicist William Astbury examined DNA using x-rays and concluded that the molecule has a helical structure. Having heard a group in the United Kingdom was attempting to unearth the structure of DNA, the American theoretical chemist, Linus Pauling, adopted Astbury’s data and proposed a model for the structure of DNA, publishing the results in the journal “Nature” in January 1953.
There was an obscure but remarkably talented person, Rosalind Franklin, pursuing x-ray diffraction studies on DNA at King’s College London. After a painstaking effort, she obtained accurate x-ray diffraction images of DNA. Her colleague, Maurice Wilkins, working in the same laboratory, passed the images to Francis Crick and James Watson at Cavendish Laboratory.
Crick and Watson were more insightful and theoretical in their approach to elucidating the structure of DNA. They, inspired by Erwin Schrodinger’s hypothesis, that the entity accounting for heredity should be an aperiodic molecular entity in cells, arrived at the double helix model, showing that Linus Pauling’s model was erroneous. The Crick – Watson model explained how DNA stores information and replicates during cell division. Their assertions were subsequently confirmed rigorously by experimentation. Crick, Watson and Wilkins received the Nobel Prize for Physiology and Medicine in 1962.
The work following the Crick – Watson model, firmly established that the DNA is a polymer string constituted of two strands made of a sugar- phosphate backbone, connected to each other by linkage nucleotide bases A, T, G, C. The base A links base T and G to C. When one strand is defined by the arrangement of bases, the complementary strand is defined. The arrangement bases store information analogously to a four-letter alphabet. Each individual in a species has a unique sequence of arrangement base pairs. The variation within the species is generally a fraction of a percent.
The Watson-Crick model also explained how the DNA molecule replicates. The two strands unwind and separate, and two complementary strands are inserted. The detailed dynamics of the replication process are not fully understood.
‘DNA is a cookbook’
DNA functions like a multiple – volume cookbook, written in a four-letter alphabet. The volumes are kept in a rack in the kitchen. The rack is the nucleus and volumes on it are the chromosomes, and the cell is the kitchen. A paragraph giving a recipe is a gene. Enzymes act as chefs, who read recipes and give instructions to cell machinery to prepare the dishes, which are proteins. The system is so complex; a complete macroscopic analogy would be impossible.
The significance of the Crick- Watson work
Until Charles Darwin proposed the idea of evolution, biology lacked a theoretical foundation. Darwin hypothesized, when organisms reproduce, the progeny inherit parental characters, but there are variations. The variants, though similar to the parents, have some new or altered characters. If these characters, originating from mutations or cross – breeding are favorable for survival in the environment, they dominate in the population, inheriting advantageous traits. Thus, random generation – to – generation, advancements of living organisms, become possible – a way of improving the design of things in a production process without a designer. Living systems store information and progeny retrieve them, when required. A bird hatched from an egg when matured, knows how to fly.
The discovery of DNA and understanding how it stores genetic information, replicates and mutates explained Darwinian evolution. A mutation is a change in the ordering of base pairs, accidentally during replication or due to external chemical or physical causes. In sexual reproduction, the offspring gets nearly half of its DNA from each parent. Consequently, the offspring does not have DNA identical to one parent. It mixes up DNA in the species. However, mutations generate new genes, driving evolution. Sexual reproduction and mutation acting in concert introduced the diversity of life on earth we see today.
Once science becomes explanatory and predictive, it opens the way for innovations. Theories of mechanics and electromagnetism formulated in the late 19th and early 20th centuries brought forth modern engineering, transforming it from an empirical craft to a scientific technological discipline. Before the discovery of DNA structure and its function, biological innovations were largely empirical. Today we have genetic engineering – genes in organisms can be manipulated. The goal of more advanced genetic engineering, referred to as synthetic biology, aims to induce major genetic changes to organisms by incorporating several genes to alter biochemical, physiological and anatomical functions. Gene technology is rapidly transforming medicine, agriculture and biotechnology. Cures have been found for diseases formerly branded incurable.
How did DNA come into existence
Life is believed to have originated in prebiotic oceans enriched with carbon and nitrogenous substances. How did DNA originate there? Today, chemists can synthesize DNA in minutes, via selective procedures, only humans can do with their knowledge. Even in a vast ocean containing trillions of times more molecular ingredients than in a test tube, a molecule as complex as DNA is most unlikely to be created by random events during the largest possible time scales of the universe. A plausible scenario would be DNA evolving from simpler self-replicating molecules such as RNA (a single strand of DNA) precursors. Unlike RNA, DNA is highly stable and good stability is necessary for the evolution of advanced forms of life.
Epigenetics
Earlier we pointed out there are two golden sayings in our culture: “Arae gathi nare” and “Jammeta wada lokuei purudha (“Hereditary characters persist” and “Habits overtake heredity “). The first is a consequence of our genetic predisposition determined by DNA and explicit genes. However, the character of an individual is also influenced by the physical, social and cultural environment. Although completely non-genetic, our children frequently follow habits we indulge in. Again, the behavior of an individual is also influenced by the physical, social and cultural environment.
The environmental factors also trigger or silence genes. The study of this important genetic effect, which does not alter the sequence of base pairs, is referred to as epigenetics. Epigenetic effects could be deleterious or beneficial. Sometimes, chronic stress causes disease, including cancer. Research suggests engagement in creative and imaginative activities, and establishes favorable epigenetic changes in the brain. Inheritance is dictated mainly by the arrangement of base pairs in DNA. Epigenetic changes involve chemical changes in DNA without altering the sequence. These alterations are erasable but allow transmission to subsequent generations.
Conclusion: World DNA day message to lawmakers
The discovery of the structure of DNA stands as one of the most significant scientific discoveries in human history. It is a lesson to all those involved in research and education, telling how great discoveries originated. It is intense curiosity, imagination and preparation rather than mere indulgence in technologies that clear the path for discovery and innovation. A society that advocates policies conducive to discoveries, also develops new technologies that follow. If we just borrow technologies from places where they originated, hoping for quick economic returns, the effort would be a gross failure. Students, determined to be the best judging from exam performance, engage in professional disciplines and perform exceptionally. Why are we short of discoveries and innovations in those disciplines? Will our lawmakers ever realize the issue? They need to wonder why we are weak in science and poor in innovation. Right policies can even reverse adverse epigenetic attributes propagating in a society!
By Prof. Kirthi Tennakone
ktenna@yahoo.co.uk
National Institute of Fundamental Studies
Features
Is power devolution under JVP-NPP a political daydream?
The JVP General Secretary Tilvin Silva’s recent remarks at a news conference in Jaffna where he ruled out the possibility of holding provincial council elections this year has been widely reported and widely criticized. About the same time there was another media event in Jaffna that went largely unnoticed and unreported outside Jaffna. What was said at the second media event may carry far more political implications than Tilvin Silva’s election timing talk. A veteran Tamil political participant made the startling yet not implausible statement that the prospect of having political devolution under the JVP-NPP government is becoming “a daydream”. The statement was made by Dr. K. Vigneswaran, who served as Provincial Secretary to the only North-East Provincial Council Government that was elected under the auspices of the Thirteenth Amendment.
Dr. Vigneswaran is a Professional Civil Engineer who studied at Royal College, graduated with First Class Honours in Engineering in 1964, and went on to complete a pioneering PhD at the university of Waterloo, Canada, applying the finite element method (FEM) in the field of Geotechnical Engineering. His engineering career has always been at the Irrigation Department where he rose to a Deputy Director. That was when the department was in its golden years, and Vigneswaran was known for his technical mentorship, meticulous administrative skills, and for knowing the fine print of everything. While at the Irrigation Department, Vigneswaran married Ramya de Silva, a fellow irrigation Engineer. After 1983, Vigneswaran became a fulltime political activist and a powerful resource in Tamil politics, but with unwavering commitment to nonviolence, democracy and federalism. The family moved first to India and then Canada, and Vigneswaran has been shuttling between Canada and Sri Lanka.
Devolution: Tortuous Trajectory
Since 1987, the Indo-Sri Lanka Agreement, and the 13th Amendment, Vigneswaran has been a permanent fixture in all the politics and institutional dynamic of implementing 13A and establishing provincial councils. He served as Secretary to the only elected Provincial Government for the Northern and Eastern Provinces. After 1994 and the election of Chandrika Kumaratunga as President, Vigneswaran became a key participant in all the civil society efforts and government initiatives to restore the PCs and implement 13A, both during the Kumaratunga presidency and the succeeding administrations of Mahinda Rajapaksa and the Sirisena-Wickremesinghe duo.
Devolution efforts stalled after the election of Gotabaya Rajapaksa, who in so many words declared that he had no time for 13A or PCs in his presidential agenda, whatever it was. Only that his whole agenda turned out to be a wholesale disaster for the country. Already by then, all the nine Provincial Councils had fallen into abeyance with the cancellation of the 1988 PC elections by the Sirisena-Wickremesinghe duo, with the TNA standing by. The abeyance continues under the JVP-NPP government with no apparent end in sight after Tilvin de Silva’s statement in Jaffna.
I say all this to provide the proper context for Vigneswaran’s statement in Jaffna that the prospects for power devolution under the JVP-NPP government are becoming a political daydream. He said something else as well: that of all the government leaders he has encountered over the years, the only leader who has been genuinely sincere about power devolution is former President Chandrika Kumaratunga, and no one else. I am constrained to add that the insincere category would include Ranil Wickremesinghe, who for all his handsome promises, never matched any of them with experiential sincerity. The present JVP-NPP government still has time to show that they are not an insincere lot.
It is not my purpose to agree with or question Dr. Vigneswaran’s assertions, but to use them as cue and context to comment on the widening mismatch between the JVP-NPP government’s promises and its practices on the matter of power devolution and the restoration of the PC system. With a stalling economy, rising prices and external shocks, it is obvious that the government has all the economic matters to worry about, but that does not mean that it can ignore all the other government responsibilities. No government is put in power to solve a single problem or address a single issue. It is in the nature of governments to deal with multiple problems with varying priorities. Otherwise you could have a single cabinet minister to deal with one problem at a time. That is never going to be the case.
The economy is of course the top of mind priority for the government even as it is a top of mind concern for the people. Even on the economic front, the government is holding steady but is showing little progress. And there are other government initiatives where political accountability will call for answers: to wit, the catchall Clean Sri Lanka programme, ambitious educational reforms, contentious energy sector reforms and, yes, power devolution as well as the overpromised constitutional reforms. Not to mention the sprawling unforced errors over substandard coal imports, foreign exchange fraud, and the chronic neglect of developing the renewable energy sector. Correcting these fields of errors may require a separate ministry for each.
Devolution: Daydream or Deliverable
On the PC system and constitutional reform, there has been scant progress in spite of handsome promises. On both, the government is inadvertently deepening the holes that it had dug itself into through indifference, inaction or procrastination, or all of them and more. In the matter of devolution and provincial councils, the government can simply defuse the situation by directing the Election Commission to conduct elections at the earliest opportunity that is logistically possible. Making his statement in Jaffna, Mr. Tilvin Silva alluded to funding shortfall and legal complications as reasons for the necessity to postpone PC elections until next year. Neither reason holds water.
The funding question would seem to have been put to rest by the statement of Health Minister and Cabinet Spokesman Nalinda Jayatissa, presumably reflecting cabinet consensus, that there are no funding issues and if needed additional funds could be arranged through supplementary allocations. It is also disingenuous to cite legal complications as a reason. The so called legal complications arose because of the collective stupidity of the Sirisena-Wickremesinghe parliament that included the then miniscule NPP and the politically-lost TNA. The JVP-NPP has now ballooned from a handful MPs to a two-thirds majority and it can expedite any legislation that it wants to enable the PC elections to be held without delays.
Alternatively, the elections can be held under the old arrangement of proportional representation with assurance by political parties to honour their commitment to fielding more female candidates. Already at a gathering of all political parties, including the NPP (but not the JVP), and civil society groups, convened by People’s Action For Free & Fair Elections (PAFFREL), the political parties jointly committed to a 25% quota for women and youth under the old electoral system. The ongoing parliamentary committee exercise studying the legal matter, headed by the overstretched Foreign Minister Vijitha Herath, is also an unnecessary red herring. The Election Commission is ready to go under whatever law or electoral system that is before it. So, there is no reason to hide behind legal complications to further delay the PC elections.
Somewhat amusingly, Public and Parliamentary Affairs Minister Ananda Wijepala has trotted out the argument that the NPP government has already conducted two nationwide elections during the one and a half years it has been in office, and that unlike the Ranil Wickremesinghe government the JVP-NPP is not in the business “to delay elections for our personal benefit” – whatever that means. Unfortunately, the good minister is missing the point. The question is not how many elections can the JVP-NPP hold in how many years, but how many years do people in the provinces have to wait before they vote in another provincial election? How many more years? That really is the question.
We know the current situation in the provinces. There are provincial governments but no elected provincial councils. The government administration in every province is being run by the President of the Republic through his handpicked governors and unelected government officials. This is a travesty of democracy and the euthanizing of the PC system. Already under 13A, the office of the provincial governors has been constitutionally and legally compared to the office of the Governors of old Ceylon who represented the monarch in what was then a crown colony. The irony is that a JVP-NPP President may have inadvertently positioned himself as the monarch of all he provincially surveys, courtesy of the Thirteenth Amendment!
The JVP was in the forefront of the litigation that caused the demerger of the Northern and Eastern Provinces. If Dr. Vigneswaran’s assertion were to prove correct, a potential dissolution of the provincial system under the JVP-NPP government would be the consummation of the JVP’s original opposition to the introduction of the provincial council system itself. The whole system may not be eradicated, but it could be devoured of its democratic essence while preserving the administrative shell as the medium for the country’s president to overreach into the provinces. That would be worse than a daydream, a real nightmare.
by Rajan Philips ✍️
Features
Rewiring Brain: Meditation to Break the Cycle of Craving
“Craving begets sorrow, craving begets fear. For him who is free from craving there is no sorrow; how can there be fear for him,” Dhammapada verse 216 states. The mental factor craving, Tanha in Pali, is central to Buddhist Teaching, as its ultimate goal is the cessation or extinction of it—tanhakkhaya. Even though Tanha is translated as craving here, it can sometimes mislead modern readers into thinking tanha only refers to extreme or physical addictions. Just as with any Pali term, it has broad meanings. Venerable Walpola Rahula describes it as “thirst” or unceasing wanting, one of the deep-rooted proclivities or latent tendencies (anusaya) of life (Rahula 1959), without which life as we know would not exist.
Even though the Buddha recognized this natural phenomenon two and a half millennia ago, it was only in the late 20th century that science took note of it and gave it a captivating term—the Hedonic Treadmill. The advantage of this empirical investigation to us Buddhists is that it provides a way to gain penetrative, experiential comprehension (anubodha) of this concept using the vernacular of this technology-savvy age—an alternative to struggling with the language of a bygone era.
These investigations have revealed that there are no hard-to-comprehend metaphysical or mysterious elements involved with this phenomenon; it is a biochemical process fundamental to sustaining life. What is more, an effort to grasp this concept would be well within the goals of Vipassana meditation described in the Sutta Pitaka, incorporating the four elements of investigation: body (kayanupassana), sensations (vedananupassana), mind (chittanupassana), and natural laws (dhammanupassana).
Vipassana and modern science
Vipassana meditation is an in-depth exploration of how humans perceive the world, gain knowledge, and interact with themselves and the environment. Knowing this with wisdom allows one to lead a harmonious way of life (samadhi), a condition conducive to curbing the “thirst” and achieving the Buddhist ideal. The goal of modern science is also to investigate life, but humanity has often used that knowledge to increase material wealth and comfort, providing only lip service to spirituality on the fringe.
An attitude that tends to ignore the consequences of wanting more and more – thirst, potentially endangering the planet. However, that does not prevent us from using scientific information as and aid or a tool to grasp Buddhist concepts. The scientific method bears parallels to the Buddhist approach: it is based on causality (paticcasamuppada), empirical verification (ehipassiko), systematic observation (meditation), and rejecting dogma and beliefs. The primary difference is simply the vocabulary used.
The process of perception: five aggregates
Our five external sense organs receive data (vedana) containing information on the environment: Eyes: receive light, Ears: receive sound, Skin: senses physical contact and temperature, Nose & Tongue: sense chemical properties of substances. The data received by the sense organs is transmitted to the brain, where it is registered as neural networks (sanna). Neural networks, which are interconnected groups of nerve cells (neurons) can be viewed as mind-readable QR codes.
The activity of the brain, or mind (mano), processes this data and converts them into actionable information (sankhara). Modern neuroscience and psychology have made great advances in understanding these processes at the molecular level. This process allows the individual to become aware of their environment, build an autobiographical memory or the notion of a self (atta), and take actions to protect and perpetuate life.
The Pali term vinnana refers to the collection of information committed to memory. Translating vinnana as “consciousness” can be confusing, as the latter often refers to all brain activities. All physical phenomena that sense organs encounter and the mental constructs (sankhara) are referred to as Rupa. This activity of mind forms the basis of all knowledge, representing the entire world as perceived by the individual. This process is what the Teaching refers to as the Five Aggregates (pancakkhanda). The critical takeaway is that the world we perceive is merely a mental construct. While an objective world exists, our sense organs have limitations in seeing it—a fact easily realized through the hundreds of illusions used for entertainment.
Evolution and emotion
The evolutionary purpose of this data processing mechanism is to enable living beings to respond to environmental factors for survival. The psychological and physiological state that arises prior to acting is called emotion. Primarily, emotions can be of three kinds: desire (loba) – seeing a new phone causes an urge to buy it, even though the current one works fine; aversion (dosha) – encountering a vicious dog triggers a “fight or flight” response; delusion (moha) or illusion – an unanswered message to a loved one triggers worry or speculation. Thus, tanha or thirst represents how we connect to the world in its entirety; it can be desire, aversion, and delusion, not merely simple greed. Consequently, these are natural phenomena beyond our immediate control, which are intended to sustain life. In other words, emotions are the forerunner to volitions or intentions, which the Teaching defines as kamma.
The biochemistry of craving
Emotions result from the interaction between the nervous system and biochemicals known as neurotransmitters and neuromodulators (e.g., dopamine, serotonin, epinephrine, GABA, glutamate, acetylcholine, and endorphins). Just as the Buddha’s simile of two bundles of bamboo supporting each other describes, these two processes are interdependent and co-arising. Every thought or emotional state corresponds to patterns of neural firing. When neurons fire, they release these chemicals into synapses, influencing how one feels and acts. This release perturbs the body’s normal balance, or homeostasis. Once an action is complete, these chemicals are reabsorbed, and the body returns to its baseline.
Return to baseline is essential for survival. For example, if we stay satisfied with just one meal forever, we could not sustain life. Nature has developed another mechanism to prevent us from being satisfied – we also habituate. In the case of dopamine, the brain adapts by reducing the response to the same stimulus. To get the same level of satisfaction with repeated experiences, the amounts of neurotransmitters needed keeps increasing. This leads to the cycle of craving and dissatisfaction—the Hedonic Treadmill. You “run” toward happiness on the treadmill, but it does not take you anywhere, leaving you in the same emotionally unsatisfactory state, wanting more and more.
Breaking the cycle
This explains why achievements and possessions do not bring permanent happiness, and lead to a cycle of struggle, addiction, crime, and other ills of society. For Buddhists, it also explains why we cling to meaningless rituals. The Dhamma captured this complex phenomenon in the Four Noble Truths: pleasant experiences are impermanent (anicca), leading to grasping (tanha) and unsatisfactoriness (dukkha). The remedy is the Eightfold Path that involves wisdom (panna), conduct (sila), and harmony (samadhi).
Neuroplasticity and the point of liberation
While we cannot stop the sense organs from receiving stimulation (vedana) and sending them to brain, the mind can be developed to prevent vedana from leading to tanha. This is the “point of liberation,” the seventh link in the paticcasamuppada formula. We may not have free will, but we have ‘Free Won’t’ or the ability to say no to the natural tendency to act upon stimuli. We can rewire our neural connections to do so. This ability can be cultivated by practice and repetition, and neuroscience refers to it as neuroplasticity—the brain’s ability to change with experience.
The natural tendency of the brain is to strengthen frequently used neural networks while weakening and eliminating lesser used networks and building new ones as needed. This is known as neural plasticity or rewiring the brain. As described in the Eight-fold Path, the way to weaken and eliminate dopamine-driven neural networks includes three aspects. First, the process leading to thirst must be understood. One must engage in sila – activities and thoughts that cultivate Metta: loving-kindness and goodwill, Karuna: compassion, Mudita: appreciative joy, and Upekkha: equanimity, emotional stability, calmness, and evenness of mind in the face of gain and loss, praise and blame, fame and disrepute, pleasure, and pain. That must be done with wisdom, ritualistic behavior does not strengthen the correct neural networks. These activities promote a “cocktail” of oxytocin, serotonin, and GABA, subduing the role of dopamine and helping us step off the Hedonic Treadmill. This leads to a tranquil state of mind and a harmonious existence – samadhi. Again, it is an interdependent, co-arising process that improves upon repetition. Using mind altering substances hijacks this process, thus the need for adhering to the Fifth Precept.
The goal of Vipassana is to understand this process and train the mind to say “no” to tanha. It is not just about sitting on a mat; it requires developing a lifestyle that maintains homeostasis or harmony, samadhi, at every moment. Pali term bhavana means the development of wisdom and insight. In modern vernacular – rewiring brain. This model must be assessed for its efficacy by the individual and realize the benefits by themselves –ehipassiko; knowledge without practice does not work. According to what the Buddha taught, that is the path to cessation or extinction of craving – tanhakkhaya, the supreme goal.
by Geewananda Gunawardana, Ph.D. ✍️
Features
‘Spectrum’ Art Exhibition Showcases Emerging Talent at Lionel Wendt
A new art exhibition, titled Spectrum ,will be held at the Lionel Wendt Art Centre on the 20th and 21st of June 2026, bringing together a collection of works by ten emerging artists.
Athsara Wijegunawardena
Neha Thirumavalavan
Dillai Joseph
Wasantha Siriwardena
Champika Dias
Nipun Dias
Dr. Prasanna Siriwardena
Kalhari Perera
Siromi Samarasinghe
Chandana Illankone
All ten artists have trained under the guidance of renowned Sri Lankan artist Royden Gibbs, and this exhibition marks an important point in their individual journeys.
Spectrum brings together a mix of styles, subjects and approaches, giving visitors a chance to experience a wide range of work in one place. The exhibition will include pieces in watercolors, soft pastels, oils and charcoal, reflecting both the discipline and personal direction of each artist. The work ranges from scenery and portraits to still life and studies of the human form, offering different ways of seeing and interpreting familiar subjects.
- Nipun Dias
- Wasantha Siriwardena
Although they share the same mentor, each artist presents a distinct point of view. The result is a show that feels varied yet connected, with each piece carrying its own character and intent. It is this balance that gives Spectrum its identity.
The exhibition aims to support and highlight emerging talent within Sri Lanka’s art scene, while also creating a space where artists and audiences can connect. Visitors will find work that shifts between quiet observation and more expressive pieces, making it an engaging experience for both seasoned collectors and those simply interested in art.
Spectrum is expected to draw art lovers, collectors, students and members of the wider creative community. It also offers an opportunity to discover and support new artists at an early stage in their careers.
Open to the public over two days, Spectrum invites visitors to experience a range of work in a venue that has long been part of Colombo’s cultural landscape.
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