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From Sri Lanka to the frontlines of cancer research — Kenneth leads with purpose
OXFORD, Miss. – The PhRMA Foundation has awarded University of Mississippi graduate student Kenneth Hulugalla its Predoctoral Fellowship in Drug Delivery, which will support his research to develop new ways to get cancer-fighting medications to tumors.
The Pharmaceutical Research and Manufacturers of America Foundation offers up to $30,000 per year to students completing their doctoral degrees. Hulugalla, a fourth-year biomedical engineering doctoral candidate from Kandy, Sri Lanka, is the first Ole Miss student to receive the fellowship.
“The foundation looks for projects that could actually make it to clinics if they get the funding to do that,” Hulugalla said. “I really consider it a privilege to be awarded the fellowship because it’s reinforcement from people who brought impactful drugs into the market, and it’s rewarding to see that the work you’re doing matters.”
Thomas Werfel, associate professor of biomedical engineering, is Hulugalla’s research adviser and supported his application for the fellowship.
“This is a very competitive national fellowship, only given to a handful of graduate students working in the field of drug delivery each year,” he said. “Kenneth’s recognition as a PhRMA fellow is a major recognition of his talent, excellent work to date and potential to be a leader in this field of research.”
Hulugalla’s research focuses on delivering cancer medication directly to tumor cells in particularly aggressive cancers, such as triple-negative breast cancer. In 2024, Hulugalla and Werfel published research showing that nanoparticles coated in a sugar-like substance can more effectively deliver cancer-fighting medication.
“The first part of our research found that when we use these sugar molecules like glucose, they bypass immune system recognition, and they can make their way to the tumor,” he said. “But the problem that we encountered was that every human is so different.
“Based on your disease state, your age, your sex – a number of factors – the composition of proteins in each individual person’s body is going to be different. That also affects how the body reacts. If we’re making a one-size-fits-all carrier, that’s usually not the best solution.”
Hulugalla and Werfel are planning to collaborate with the University of Mississippi Medical Center and oncology clinics to use real patient serum – fluid in the blood that does not include blood cells or clotting proteins – to study different protein combinations. Their work could lead to cancer medication that is tailored to fit the person who needs it.
“This could be a major improvement because all trials to date have used a one-size-fits-all approach to choosing materials to deliver drugs to a set of patients,” Werfel said. “We believe that the variability between patients is one of the major reasons that the effectiveness of the materials varies so much.
“I believe Kenneth’s project was chosen because it does truly represent a paradigm shift in how materials are designed in a patient-specific manner to give the best possible chance of clinical success.”
Triple-negative breast cancer is one of the most aggressive forms of cancer. If the researchers can successfully find ways to address it, they could begin to use those strategies in other cancers, too.
“When people say, ‘We’re curing cancer,’ it’s really complicated, because it’s not one disease,” Hulugalla said. “It’s a multitude of different diseases, so it’s almost impossible to totally cure.
“What we’re hoping is that if we can find approaches that work well in really aggressive types of cancer, we can take those good things from that technology and apply them to other cancers.”
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“I extend my heartfelt wishes to all Sri Lankans for a peaceful and joyous Sinhala and Tamil New Year!” – President
President Anura Kumara Dissanayake, issuing a New Year message, extend his heartfelt wishes to all Sri Lankans for a peaceful and joyous Sinhala and Tamil New Year!
The Sinhala and Tamil New Year, which symbolises the aspiration for renewal both physically and spiritually, is the foremost cultural festival of the people of this country.
During the Sinhala and Tamil New Year, traditional customs are upheld, with priority accorded to rituals and religious observances, and activities undertaken collectively at a common auspicious time. This shared cultural practice vividly reflects our nation’s identity before the world, as well as the strong socio-cultural bonds that exist among our communities.
We firmly believe that the future path of national development can only be shaped in harmony with this invaluable culture and our distinguished historical heritage. Accordingly, it must be recalled that all our future development plans have been formulated upon the firm foundation of these precious traditions and cultural values.
Moreover, the common aspiration embodied in the customs and rituals associated with the solar transition is the nurturing of a compassionate individual who values togetherness, respects others, and lives in harmony with nature. I believe that the virtues and values of unity reflected in these New Year traditions should not be confined to these few days alone, but should instead be demonstrated throughout the year in our daily conduct.
In the face of the most significant recent natural disaster challenge encountered in the past year, we demonstrated to the world our resilience and capacity to withstand internal shocks. At the same time, in responding to the external challenges arising from the conflict in the Middle East, the Government has already set in motion a well-planned and effectively managed programme to overcome these difficulties.
As a nation, in overcoming these challenges together, I call upon all of you to further dedicate yourselves to enriching your lives through the values of togetherness, sharing, and solidarity exemplified during the Sinhala and Tamil New Year season.
As we strengthen the achievements we have secured and move forward with unwavering resolve in the face of emerging challenges, I invite everyone to join hands in unity to realise the vision of “A Thriving Nation – A Beautiful Life” for all.
I extend my heartfelt wishes to all Sri Lankans for a peaceful and joyous Sinhala and Tamil New Year!
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US blockade of Iran would worsen global energy crisis, analysts say
United States President Donald Trump’s planned naval blockade of Iran would further cripple international shipping, exacerbating the energy crisis roiling the global economy, analysts warn.
Oil prices surged above $100 a barrel on Monday after Trump announced that the US Navy would blockade the Strait of Hormuz and “interdict every vessel in international waters that has paid a toll to Iran”
“Iran will not be allowed to profit off this Illegal Act of EXTORTION,” Trump said on Truth Social.
Central Command, the US military’s command responsible for operations in the Middle East, said in a statement the blockade would affect only ships entering and exiting Iranian ports, an apparent scaling-back of Trump’s threat to fully block the strait.
Trita Parsi, cofounder of the US-based Quincy Institute for Responsible Statecraft, said a US blockade would have a cascading impact across the global economy.
“Anything that currently takes more oil off the market will push prices up, which in turn will push gas prices further,” Parsi told Al Jazeera.
Oil could rise above $150 a barrel if the blockade were to trigger retaliation from the Iran-aligned Houthis in Yemen, who could shut down Bab al-Mandeb, a strait that connects the Red Sea to the Gulf of Aden and Indian Ocean, Parsi said.
The strait is an alternative export route for Gulf oil and gas.
A blockade aimed at depriving Iran of revenues would mark a sudden reversal in policy by Washington.
The Trump administration last month announced it would waive some sanctions on Iranian oil exports as a way to help ease the global energy crunch.
Iran has essentially closed the strait since the start of the US-Israeli war on February 28, allowing only a small number of ships to transit after vetting and authorisation.
About 3,200 vessels were stranded west of the strait due to the blockage as of Saturday, according to the maritime intelligence company Windward.
Anas Alhajji, former chief economist at NGP Energy Capital Management, said expected non-Iranian ships would likely keep avoiding the strait despite the US military’s assurances that they will not be impeded because of elevated insurance premiums.
Ships may also fear retaliation from Iran, Alhajji said.
“Therefore, the Trump blockade of the Iranian ports is an actual blockade of the Hormuz Strait,” Alhajji told Al Jazeera.
The resulting rise in oil and gas prices would also cause the cost of chemicals, fertilisers and raw materials used to make plastics to increase, according to analysts.
Cameron Johnson, a senior partner at the Shanghai-based supply chain consultancy Tidalwave Solutions, said he expects prices of many raw materials to rise within several weeks if Trump makes good on his blockade threat.
“The wild card really is the timeframe on this,” Johnson told Al Jazeera.
“If this is a negotiating tactic – remember we still have eight or nine days left of the ceasefire – then it may not really matter. But if this prolongs itself into the end of the month and into the first week of May, you will see prices all over the world spike for raw materials.”
Deborah Elms, head of trade policy at the Hinrich Foundation in Singapore, said the situation for global supply chains could get “much worse” under the blockade.
“Some of the problems are obvious, but many are not. As an example, fabrics will get more expensive,” Elms told Al Jazeera.
“Packaging is already a challenge for firms. Many can’t get blister packs for pills or lids for consumer goods. We can expect consequences for food production later this year and into next year with fertiliser disruptions and lack of supply,” Elms said.
Chad Norville, president of the oil and gas industry news site Rigzone, said Trump’s threat is a further blow to confidence in the situation in the strait ever returning to normal.
The threat alone is likely to drive up insurance premiums for shipping and logistics companies and reduce the volume of trade passing the strait each day, he said.
“Disruptions to shipping and elevated risk in the region were already well established due to the conflict,” Norville told Al Jazeera.
“This threat doesn’t create that baseline. It amplifies it by reinforcing uncertainty around one of the world’s most critical chokepoints.”
[Aljazeera]
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“Let us resolve, with renewed determination to overcome obstacles and build a better and more prosperous nation” -PM
Prime Minister Dr Harini Amarasooriya in her New Year message requested every Sri Lankan to resolve, with renewed determination to overcome obstacles and build a better and more prosperous nation.
The full text of the PM’s message:
“Marking the auspicious transition of the sun from one planet to another, and the arrival of the spring season following the harvest, the Sinhala and Tamil New Year celebrated by the people of Sri Lanka since ancient times, has dawned once again.
The New Year is not merely a festive occasion; it symbolizes a renewal of prosperity, unity, coexistence, and the strengthening of mutual relationships embedded within our cultural values.
On this occasion, I extend my wishes for a peaceful and prosperous Sinhala and Tamil New Year to all Sri Lankans who celebrate this occasion with their families and loved ones, observing customs at the auspicious time.
A unique feature of Sinhala and Tamil New Year is the way an entire nation comes together through a shared set of customs. Despite the demands and challenges of daily life, this season offers a valuable opportunity to move forward with renewed hope as families, communities and a nation.
The true blessing of the New Year lies in setting aside differences and grievances, and embracing a fresh beginning in a spirit of solidarity and goodwill. Especially in the face of ongoing global challenges, the courage, compassion and resilience shown by our people in facing various natural and economic hardships in recent times stand as an example to the world. It is our responsibility to carry forward that collective strength.
At this auspicious moment, I extend my greetings to our fellow Sri Lankans working overseas, who dedicate themselves to securing a better future for their families and for the country. In particular, I extend my thoughts for the safety and well-being of those living in the Middle East during these tumultuous times.
Let us resolve, with renewed determination to overcome obstacles and build a better and more prosperous nation. As we undertake in a significant social and political transformations, we remain committed to striving tirelessly towards a better future.
May this Sinhala and Tamil New Year be blessed with happiness and prosperity!”
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