News
Delayed second jab may have done you good
Covishield vaccine induces immunity for at least one year following a single dose
Strong immune responses following either a late second dose or a third dose
by Emme Haddon
In early March 2021, I received my first shot of Covishield but began to get a little worried when the recommended three-month time frame had passed for the second dose with no sign of the promised shipment from India. Finally, in the first week of August, some months later, after what seemed like an interminable wait, I was fortunate enough to secure my second dose of Covishield, along with 490,000 or so others.
The findings of a study of Vaxzevria, the European brand name for the UK’s AstraZeneca vaccine of which the Indian-manufactured Covishield is biologically identical, from the Oxford-led COV001 and COV002 trials by researchers at the University of Oxford, released on June 28, 2021 on the pre-preprint server of the Lancet, demonstrated that antibody levels remain elevated from baseline for at least one year following a single dose.
Furthermore, a 45-week dosing interval between the first and second dose of Covishield, resulted in an 18-fold increase in antibody response, measured 28 days after the second dose. Antibody titers (test determining level of antibodiess in the blood) were four times higher than with a 12-week interval, demonstrating that a longer dosing interval is not detrimental but can derive stronger immunity. The analysis included volunteers aged 18 to 55 years who were enrolled in COV001 and COV002 trials and had received either a single dose or two doses of COVID-19 Vaccine AstraZeneca.
In addition, a third dose of Vaxzevria given at least sixmonths after a second dose, boosted antibody levels sixfold, maintained T cell response and also resulted in higher neutralising activity against the Alpha (B.1.1.7, ‘Kent’), Beta (B.1.351, ‘South African’) and Delta (B.1.617.2, ‘Indian’) variants. Both the late second dose and the third dose of Vaxzevria were less reactogenic than the first dose.
It seems that those of us who patiently endured a five-month wait for their second dose of Covishield, may in fact, be better protected than those who, by whatever means they felt necessary, managed to secure their second dose in the previously recommended three-month dosing interval, before supplies ran out. As the old adage goes: good things come to those who wait springs to mind!
The release of the findings of a second study on July 28. 2021, by researchers from the University of Oxford, concluded that the risk of the rare blood clotting thrombocytopenia, venous thromboembolism and arterial thromboembolism after receiving first doses of AstraZeneca or Pfizer COVID-19 jabs is far lower than from the actual virus.
Rates of venous thromboembolism were eight times higher after a diagnosis of COVID-19 infection compared with the expected rate. Many developed countries limited AstraZeneca’s use to older adults because of concerns about an elevated risk of blood clots affecting the younger population. These findings should allay any fears about the vaccine’s safety.
Results from the Canadian Immunization Research Network with support from the Public Health Agency of Canada and the Canadian Institutes of Health Research, published as a pre-print on July 23, 2021, showed that one dose of Vaxzevria (Covishield) was 82% effective against Beta/Gamma and 87% and 90 % effective against the Delta (B.617.2, ‘Indian’) and Alpha (B.1.1.7, ‘Kent’) variants’ hospitalisation or death.
Research into the coronavirus is on-going and it important to ensure that officials keep abreast of new developments and plan accordingly. In countries such as Sri Lanka with limited resources, hard hit economically by Covid-19, where the majority of those under the age of 30 have yet to receive a first vaccine, the findings that Covishield’s antibody levels remain elevated from baseline for at least one year following a single dose, with increased immunity provided as a result of a longer dosing interval are potentially game-changing.
The Delta virus variant has changed the shape of the pandemic. At a time when the vaccination program is struggling to keep up with rapid transmission of the Delta variant, any Covishield vaccines kept aside for second doses, might be better utilised now as first doses to prevent hospitalizations and deaths in those higher risk as yet unvaccinated groups.
News
PSTA worse than PTA: FSP
The Frontline Socialist Party (FSP) yesterday accused the government of seeking to use the proposed Protection of the State from Terrorism Act (PSTA) to suppress popular political activity, claiming that some of its provisions were more repressive than those of the Prevention of Terrorism Act (PTA).
FSP Education Secretary Pubudu Jayagoda told a media briefing, in Nugegoda, that the definition of terrorism in the Bill was so broad that it could be used to label almost any form of popular political activity as terrorism.
He said the Bill’s approach to defining terrorism was based largely on attempts to compel a government, or an international organisation, to do, or refrain from doing something, rather than on internationally recognised criteria, such as killings, causing serious bodily harm, kidnapping or acts intended to spread terror among the public.
Jayagoda also alleged that the Bill transferred substantial powers from the judiciary to the executive, while extending powers of arrest, investigation and detention to the armed forces, in addition to the police.
He claimed that the government had sought to portray the Bill as a replacement for the PTA while retaining or introducing provisions that could facilitate political victimisation and repression.
The FSP also questioned the government’s decision to proceed with the Bill, despite having previously sought public views on an earlier draft.
Jayagoda said a draft had been published earlier this year, with the period for public submissions ending on February 28, but the Bill subsequently gazetted was essentially the same draft with some provisions rearranged.
Jayagoda also referred to a letter reportedly sent by Attorney-at-Law Saliya Peiris, a member of a Committee, chaired by President’s Counsel Rienzie Arsecularatne, that had been appointed to draft the legislation. He said Peiris had stated, in the October 06 letter, that changes had been made to the draft prepared by the Committee.
“This means that even the Committee, appointed to prepare the Bill, was a deception,” Jayagoda alleged.
He said that the PSTA was fundamentally similar to the Anti-Terrorism Bill introduced by the previous government, in 2023, which the National People’s Power (NPP) opposed and challenged in court.
“If the NPP opposed that Bill then and is now bringing the same legislation before Parliament, the government must explain its position,” he said.
Jayagoda called on NPP MPs to oppose the PSTA in Parliament and urged trade unions and other groups to build a broad public movement against the legislation.
He challenged the government to an open debate on the Bill.
News
Shiranthi R remanded until 13 Oct.
Former First Lady Shiranthi Rajapaksa was yesterday remanded until 13 October after being produced before the Colombo Magistrate’s Court following her arrest by the Commission to Investigate Allegations of Bribery or Corruption (CIABOC).
Shiranthi, wife of former President Mahinda Rajapaksa, was arrested at her residence on Poorwarama Road, Kirulapone, after CIABOC officers recorded a statement from her for nearly two hours.
According to the CIABOC, the arrest was made over allegations that Rs. 10 million obtained from the National Savings Bank through the Siriliya Saviya organisation was misappropriated.
The money was allegedly obtained to provide a Computed Tomography (CT) scanner to the children’s hospital. Investigators allege that the scanner was not provided and that the funds were instead unlawfully used.
CIABOC is investigating alleged offences under the Public Property Act and corruption-related provisions in connection with the transaction and other financial activities involving Siriliya Saviya, which was headed by Rajapaksa.
Rajapaksa returned to Sri Lanka on Monday night on a flight from Malaysia after travelling overseas for medical treatment. She left for Singapore on 16 September after being admitted to a private hospital in Colombo on 15 September following an illness.
She had been due to appear before the Financial Crimes Investigation Division (FCID) on 13 October in connection with its investigation into the financial affairs of Siriliya Saviya.
Meanwhile, her lawyers filed an anticipatory bail application before the Maligakanda Magistrate’s Court on Monday, seeking an order preventing her arrest in connection with the FCID investigation.
News
Former NSB Chairman Kariyawasam granted bail
Former National Savings Bank (NSB) Chairman Pradeep Kariyawasam was yesterday granted bail by the Colombo Magistrate’s Court following his arrest by the Commission to Investigate Allegations of Bribery or Corruption (CIABOC).
Kariyawasam, husband of former Chief Justice Shirani Bandaranayake, was arrested in connection with the Bribery Commission’s investigation into the ‘Siriliya Saviya’ account linked to former First Lady Shiranthi Rajapaksa.
The investigation concerns financial activities involving the Siriliya Saviya initiative, which was headed by Rajapaksa, wife of former President Mahinda Rajapaksa.
CIABOC is continuing investigations into the alleged financial irregularities relating to the account.
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