News
Delayed second jab may have done you good
Covishield vaccine induces immunity for at least one year following a single dose
Strong immune responses following either a late second dose or a third dose
by Emme Haddon
In early March 2021, I received my first shot of Covishield but began to get a little worried when the recommended three-month time frame had passed for the second dose with no sign of the promised shipment from India. Finally, in the first week of August, some months later, after what seemed like an interminable wait, I was fortunate enough to secure my second dose of Covishield, along with 490,000 or so others.
The findings of a study of Vaxzevria, the European brand name for the UK’s AstraZeneca vaccine of which the Indian-manufactured Covishield is biologically identical, from the Oxford-led COV001 and COV002 trials by researchers at the University of Oxford, released on June 28, 2021 on the pre-preprint server of the Lancet, demonstrated that antibody levels remain elevated from baseline for at least one year following a single dose.
Furthermore, a 45-week dosing interval between the first and second dose of Covishield, resulted in an 18-fold increase in antibody response, measured 28 days after the second dose. Antibody titers (test determining level of antibodiess in the blood) were four times higher than with a 12-week interval, demonstrating that a longer dosing interval is not detrimental but can derive stronger immunity. The analysis included volunteers aged 18 to 55 years who were enrolled in COV001 and COV002 trials and had received either a single dose or two doses of COVID-19 Vaccine AstraZeneca.
In addition, a third dose of Vaxzevria given at least sixmonths after a second dose, boosted antibody levels sixfold, maintained T cell response and also resulted in higher neutralising activity against the Alpha (B.1.1.7, ‘Kent’), Beta (B.1.351, ‘South African’) and Delta (B.1.617.2, ‘Indian’) variants. Both the late second dose and the third dose of Vaxzevria were less reactogenic than the first dose.
It seems that those of us who patiently endured a five-month wait for their second dose of Covishield, may in fact, be better protected than those who, by whatever means they felt necessary, managed to secure their second dose in the previously recommended three-month dosing interval, before supplies ran out. As the old adage goes: good things come to those who wait springs to mind!
The release of the findings of a second study on July 28. 2021, by researchers from the University of Oxford, concluded that the risk of the rare blood clotting thrombocytopenia, venous thromboembolism and arterial thromboembolism after receiving first doses of AstraZeneca or Pfizer COVID-19 jabs is far lower than from the actual virus.
Rates of venous thromboembolism were eight times higher after a diagnosis of COVID-19 infection compared with the expected rate. Many developed countries limited AstraZeneca’s use to older adults because of concerns about an elevated risk of blood clots affecting the younger population. These findings should allay any fears about the vaccine’s safety.
Results from the Canadian Immunization Research Network with support from the Public Health Agency of Canada and the Canadian Institutes of Health Research, published as a pre-print on July 23, 2021, showed that one dose of Vaxzevria (Covishield) was 82% effective against Beta/Gamma and 87% and 90 % effective against the Delta (B.617.2, ‘Indian’) and Alpha (B.1.1.7, ‘Kent’) variants’ hospitalisation or death.
Research into the coronavirus is on-going and it important to ensure that officials keep abreast of new developments and plan accordingly. In countries such as Sri Lanka with limited resources, hard hit economically by Covid-19, where the majority of those under the age of 30 have yet to receive a first vaccine, the findings that Covishield’s antibody levels remain elevated from baseline for at least one year following a single dose, with increased immunity provided as a result of a longer dosing interval are potentially game-changing.
The Delta virus variant has changed the shape of the pandemic. At a time when the vaccination program is struggling to keep up with rapid transmission of the Delta variant, any Covishield vaccines kept aside for second doses, might be better utilised now as first doses to prevent hospitalizations and deaths in those higher risk as yet unvaccinated groups.
News
Prison officers urge Justice Minister to protect their colleague who opened fire
Prison officers yesterday requested Justice and National Integration Minister Harshana Nanayakkara to protect their colleague who opened fire at the Negombo Prison during Monday’s riot.
They made that request when the Minister visited the Welikada Prison to pay his last respects to seven officers killed by inmates during the clashes. Soon thereafter, the National Hospital reported that another prison officer had succumbed to his injuries.
The Minister was told that the officer had opened fire through a small opening in the main door to prevent the rioting prisoners from escaping.
The Opposition has demanded to know who ordered the prisons officer to fire. The concerned officer’s colleagues told the Minister that had a breakout occurred the inmates would have posed a serious threat to the public.
Altogether, authorities transferred 1,033 inmates from Negombo to other prisons. Among them was Katuwellegama Suresh, who is alleged to have spearheaded Sunday’s attack on a group of prisoners that led to the following day’s clashes.
Executive Director of the Committee for Protecting the Rights of Prisons, Attorney-at-Law Senaka Perera told The Island that some of the transferred inmates had been mercilessly assaulted in other prisons.
Sources familiar with the situation at prisons said that they were able to accommodate between 11,000 to 12,000 inmates but over 40,000, both convicted and suspects were held in the country’s prisons. About 30,000 of them are suspects. Due to severe overcrowding, prison management had been compelled to accommodate both the convicts and suspects at the Negombo Remand Prison, sources said, adding that the clashes had erupted between the two groups.
Those who had been convicted were accused by the other group of passing information to the previous prison management resulting in elimination of narcotics and other banned items in the prison, sources said. They went on the offensive after both the administrator and the second-in-command were transferred separately and the authorities ignored the volatile situation and proceeded with routine work on Monday.
Sources said that the authorities were yet to release the exact number of convicts and suspects killed and wounded during clashes between the two groups and with prison staff. According to the Health and Media Ministry the total number of persons admitted to the National Hospital, following the incidents, were 29. Of them, 14 were inmates. The Ministry said that of the 29, 12 were in the intensive care unit.
Prof. Prathiba Mahanamahewa told The Island that the overcrowding of prisons should be carefully examined, taking into consideration that even some innocent people were held in various prisons. Poisons, Opium and Dangerous Drugs (Amendment) Act of No 41 of 2022 was being exploited and misused by law enforcement authorities to frame and arrest people. In terms of this law, those who had been framed couldn’t secure bail from the High Court but had to seek the intervention of the Court of Appeal. The lawyer explained how Section 54 of the Act was being used indiscriminately against people.
According to Mahanamahewa about 80 percent of those suspects held were on narcotic charges.
By Shamindra Ferdinando
News
Negombo Prison riot: Ensuring protection of prisoners fundamental responsibility of the state – UN
Expressing concern over the death of prisoners, both convicts and suspects, as well as correctional officers, the United Nations Resident Coordinator in Sri Lanka, Marc-André Franche has emphasised that ensuring that protection is a fundamental responsibility of the State.
Twenty prisoners and seven correctional officers were killed in clashes on Sunday and Monday. Over 100 received injuries.
Issuing a statement, the United Nations extended its condolences to the families affected by the tragedy and wished a speedy recovery to those injured.
Underscoring prison officials carried out challenging duties in service of the State, and the general public, the UN Resident Coordinator said that their loss was deeply felt. The UN also stressed that inmates who died, or were injured, were under the care and protection of the State, emphasising that both correctional officers and prisoners require greater protection. Ensuring that protection is a fundamental responsibility of the State, he said.
The UN statement highlighted the urgent need for continued investment and reform within Sri Lanka’s prison system.
It pointed to longstanding challenges, including overcrowding, outdated practices and poor conditions in detention facilities, which remain concerns in prison systems both in Sri Lanka and globally.
The UN said Sri Lanka’s engagement with international human rights standards, relating to the treatment, safety and wellbeing of persons deprived of liberty, provides an important framework for addressing these issues.
The United Nations welcomed the establishment of an independent committee to investigate the circumstances surrounding the prison violence and emphasised that the committee’s findings should lead to concrete and lasting improvements in detention conditions.
The UN also reaffirmed its commitment to supporting Sri Lanka through technical cooperation aimed at improving prison security, strengthening detention conditions, and supporting the welfare of correctional personnel.
News
Govt. considers banning or restricting social media for children under 16: PM
The government was considering imposing restrictions or a possible ban on social media access for children under 16, Prime Minister Harini Amarasuriya told Parliament yesterday (8).
Responding to a question raised by SJB Gampaha District MP Harshana Rajakaruna, the Prime Minister said discussions with relevant stakeholders were currently underway to assess the impact of social media use on children and explore measures to ensure their safety.
She said the consultations, led by the Ministry of Women and Child Affairs, were focussed on the social, mental and health effects of excessive social media use, digital security concerns and global developments in regulating online platforms.
The Prime Minister said the National Child Protection Authority and the National Childcare and Protection Society were also engaged in discussions on the proposal, while steps were being taken to draft national guidelines on restricting access to social media platforms for children below 16 years.
She added that awareness programmes would also be introduced to safeguard children’s mental and physical wellbeing in an increasingly digital environment.
According to the Prime Minister, several government institutions, including the Ministries of Women and Child Affairs, Education, Higher Education and Vocational Education, Health, Mass Media and Digital Economy, along with the Sri Lanka Police, Department of Probation and Child Care Services and the National Child Protection Authority, were collaborating on the initiative.
The PM said the government, together with World Vision, was implementing a programme aimed at addressing mobile phone addiction among children under 18, which had already shown positive results.
Prime Minister Amarasuriya said the government’s focus was to strike a balance between protecting children from potential online harms and ensuring they benefit from digital opportunities.
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