News
Delayed second jab may have done you good
Covishield vaccine induces immunity for at least one year following a single dose
Strong immune responses following either a late second dose or a third dose
by Emme Haddon
In early March 2021, I received my first shot of Covishield but began to get a little worried when the recommended three-month time frame had passed for the second dose with no sign of the promised shipment from India. Finally, in the first week of August, some months later, after what seemed like an interminable wait, I was fortunate enough to secure my second dose of Covishield, along with 490,000 or so others.
The findings of a study of Vaxzevria, the European brand name for the UK’s AstraZeneca vaccine of which the Indian-manufactured Covishield is biologically identical, from the Oxford-led COV001 and COV002 trials by researchers at the University of Oxford, released on June 28, 2021 on the pre-preprint server of the Lancet, demonstrated that antibody levels remain elevated from baseline for at least one year following a single dose.
Furthermore, a 45-week dosing interval between the first and second dose of Covishield, resulted in an 18-fold increase in antibody response, measured 28 days after the second dose. Antibody titers (test determining level of antibodiess in the blood) were four times higher than with a 12-week interval, demonstrating that a longer dosing interval is not detrimental but can derive stronger immunity. The analysis included volunteers aged 18 to 55 years who were enrolled in COV001 and COV002 trials and had received either a single dose or two doses of COVID-19 Vaccine AstraZeneca.
In addition, a third dose of Vaxzevria given at least sixmonths after a second dose, boosted antibody levels sixfold, maintained T cell response and also resulted in higher neutralising activity against the Alpha (B.1.1.7, ‘Kent’), Beta (B.1.351, ‘South African’) and Delta (B.1.617.2, ‘Indian’) variants. Both the late second dose and the third dose of Vaxzevria were less reactogenic than the first dose.
It seems that those of us who patiently endured a five-month wait for their second dose of Covishield, may in fact, be better protected than those who, by whatever means they felt necessary, managed to secure their second dose in the previously recommended three-month dosing interval, before supplies ran out. As the old adage goes: good things come to those who wait springs to mind!
The release of the findings of a second study on July 28. 2021, by researchers from the University of Oxford, concluded that the risk of the rare blood clotting thrombocytopenia, venous thromboembolism and arterial thromboembolism after receiving first doses of AstraZeneca or Pfizer COVID-19 jabs is far lower than from the actual virus.
Rates of venous thromboembolism were eight times higher after a diagnosis of COVID-19 infection compared with the expected rate. Many developed countries limited AstraZeneca’s use to older adults because of concerns about an elevated risk of blood clots affecting the younger population. These findings should allay any fears about the vaccine’s safety.
Results from the Canadian Immunization Research Network with support from the Public Health Agency of Canada and the Canadian Institutes of Health Research, published as a pre-print on July 23, 2021, showed that one dose of Vaxzevria (Covishield) was 82% effective against Beta/Gamma and 87% and 90 % effective against the Delta (B.617.2, ‘Indian’) and Alpha (B.1.1.7, ‘Kent’) variants’ hospitalisation or death.
Research into the coronavirus is on-going and it important to ensure that officials keep abreast of new developments and plan accordingly. In countries such as Sri Lanka with limited resources, hard hit economically by Covid-19, where the majority of those under the age of 30 have yet to receive a first vaccine, the findings that Covishield’s antibody levels remain elevated from baseline for at least one year following a single dose, with increased immunity provided as a result of a longer dosing interval are potentially game-changing.
The Delta virus variant has changed the shape of the pandemic. At a time when the vaccination program is struggling to keep up with rapid transmission of the Delta variant, any Covishield vaccines kept aside for second doses, might be better utilised now as first doses to prevent hospitalizations and deaths in those higher risk as yet unvaccinated groups.
News
Athapaththu and Dilhari muscle Sri Lanka past Malaysia in mismatch
The quarter-finals of the Asian Games women’s competition, putting top-notch teams against teams without much experience of playing at the highest level, were expected to be mismatches. It took till the third game – Bangladesh vs China was washed out and Thailand gave Pakistan a fright for a proper one-side affair, though, as Sri Lanka bashed 160 after opting to bat, and their bowlers then stopped Malaysia 86 runs short.
Fresh off their appearance in the final of the Women’s T20 Asia Cup, Sri Lanka were always expected to dominate, but it didn’t quite start the way they wanted, with Imesha Dulani run out for another low score in the third over – she hasn’t topped 25 in eight innings since her century against Pakistan on July 31.
Chamari Athapaththu, however, stitched together an 80-run stand off just 53 balls with Hasini Perera for the second wicket, scoring 56 runs in 27 balls to Perera’s 23 in 26 in the collaboration. After the two batters fell, Kavisha Dilhari played a similar role to Athapaththu in the stand with Harshitha Samarawickrama, scoring 36 in 19 in a stand worth 62 in 37 balls.
Athapaththu top-scored with 63 in 37 balls, while Dilhari’s unbeaten 44 came off just 27 balls. For Malaysia, offspinner Nurin Imanina impressed with 3 for 29 from her four overs, picking up all the wickets to fall to bowlers.
In reply, Malaysia were three down inside the powerplay, with Dilhari picking up two of the wickets to fall on her way to returns of 2 for 4 from three overs. Athapaththu chipped in with two wickets of her own to finish with 2 for 3 from two overs, while Mithali Ayodhya got 2 for 15 from three.
It’s not like there was no resistance from Malaysia: Winifred Duraisingam scored 28, though it took her 47 balls to do it, while Mahirah Izzati Ismail scored 24, another slow effort, taking her 42 balls.
Scores:
Sri Lanka Women 160 for 4 in 20 overs (Athapaththu 63, HasinMithali Ayodhya 2-15i Perera 23, Kavisha Dilhari 44*, Harshitha Samarawickrema 25; Nurin Imanina 3-29) beat Malaysia Women 74 for 7 in 20 overs (Winifred Duraisingam 28, Mahirah Izzati Ismail 24; Mithali Ayodhya 2-15, Kavisha Dilhari 2-04, Chamari Athapaththu 2-03, ) by 86 runs
[Cricinfo]
News
Bid for Basil’s extradition nears final stage: Police
Govt. is finalising extradition proceedings against Basil to have him stand trial here in respect of several cases
By Norman Palihawadane
The process of having former Minister Basil Rajapaksa extradited from the US to Sri Lanka was being finalised, Police Headquarters sources disclosed yesterday.
The government has formally sought assistance from the United States government to extradite former Minister Basil Rajapaksa, as multiple courts have reissued arrest warrants over his failure to appear before them in connection with two separate criminal cases, a senior police officer told The Island.
The officer, speaking on condition of anonymity, said matters pertaining to obtaining US government authorities’ assistance to extradite Rajapaksa were now being finalised.
Police headquarters sources said law enforcement agencies were currently evaluating red notices, which request the location and provisional arrest of a person pending formal extradition.
The CID and Police Headquarters earlier initiated steps to seek INTERPOL assistance to secure Rajapaksa’s return to Sri Lanka to face court proceedings relating to the two cases in which arrest warrants have been issued against him.
Rajapaksa is believed to be residing in Los Angeles, United States.
The Matara Chief Magistrate’s Court on July 21, 2026, reissued an arrest warrant for Rajapaksa after he failed to appear before court for the second time in connection with a case involving the alleged purchase of a 1.5-acre coconut estate on Eliyakanda Road in the Brown’s Hill area of Matara.
The case relates to the purchase of the property for Rs. 60 million.
The case was filed by the Police Financial Crimes Investigation Division and names Basil Rajapaksa and several other accused, including Ayoma Galappaththi, identified in court reports as the sister of Rajapaksa’s wife, Tissa Galappaththi, and Muditha Jayakody.
However, officials acknowledged that seeking US assistance would only begin a formal international process and would not automatically result in Rajapaksa’s arrest or return to Sri Lanka. Sri Lankan authorities would need to submit court orders, details of the alleged offences, and other supporting documents through the appropriate diplomatic and judicial channels. Any request would then be considered by the relevant US authorities under American law and applicable legal arrangements.
Sources at the Foreign Ministry said sealed correspondence had been exchanged between Sri Lanka’s Ministry of Foreign Affairs and the Legal Department of the US State Department relating to corruption allegations against members of the Rajapaksa family residing in the United States.
The legal foundation for any extradition is the bilateral treaty between Sri Lanka and the United States signed in Washington on September 30, 1999. The treaty applies the principle of dual criminality, meaning authorities must show that the underlying conduct amounts to a crime in both countries. Rajapaksa’s status as a United States citizen would not, on its own, make him immune from a valid request under the treaty’s provisions.
News
High blood pressure, diabetes lead to about 80% of deaths in Sri Lanka
Non-communicable diseases (NCDs) account for 80% of all deaths in Sri Lanka, with high blood pressure and diabetes among the leading causes, Secretary to the Ministry of Health and Mass Media, Dr. Anil Jasinghe, said early this week.
Dr. Jasinghe pointed out that the two conditions were interrelated and could lead to a range of serious health complications, with heart attacks being among the most severe consequences.
Dr. Jasinghe made these remarks while attending the commencement of construction of a modern Cardiac Care Complex at the Anuradhapura Teaching Hospital on Wednesday (16).
The Health and Mass Media Ministry Secretary said:
“The main issue is that these two diseases are interconnected and cause a range of complications in a person’s health. Looking at the current situation in Sri Lanka, only around 50% of those suffering from high blood pressure are under effective control. Similarly, only around 25% of diabetic patients are under proper control. As a result, this has now become a major problem in society.
“The most serious complication associated with both these diseases is Myocardial Infarction (MI), or a heart attack. This has also become the
leading complication. So, how do we control this modern epidemic? This is the biggest challenge before us.
“While establishing modern facilities across the country, our health system must also recognize the changes that have taken place in the demographic structure of our population and disease patterns. Accordingly, our health system must be adapted to suit these changing circumstances.
“Under the policies of the government led by the President and the guidance of the Minister of Health, the Ministry of Health and Mass Media is currently implementing a major programme in this regard. Its three main components are Arogya, Cluster Systems and High-End Care Institutions, which need to be developed to suit the requirements of our health system.”
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