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Another side of Cancer

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Reading the excellent article titled ‘Tackling insidious killer’ (The Island 2025/06/04) by Priyantha Hewage, a few questions came to mind: Will there be a cure for cancer, or can cancer be eradicated, like polio or smallpox, for example? Why cancer is on the rise is another. While there are no definitive answers to them at this point, based on the known molecular biology of cancer, we can make some reasonable guesses.

There is a common (mis)conception that our genetic material, or DNA, short for deoxyribonucleic acid, is the driver of life. DNA is purely a set of instructions, which can be likened to an instruction manual on how to build, maintain, and replicate an organism. Contrary to widespread belief, DNA itself cannot do anything. How can a cookbook be expected to bake a cake, for example? Someone must read the instructions, gather the ingredients, mix them appropriately, and bake it as directed. In living organisms, it is the proteins that do all that work, not DNA. There is a strange relationship between DNA and proteins: proteins build DNA that contains the instructions to build proteins! It can be counterintuitive; the relationship between the chicken and the egg comes to mind. When we go down the path, it becomes clear that the proteins are responsible for cancer. But wait, do not throw out that meat dish out the window, not yet. Protein is a generic name. It includes enzymes, hormones, antibodies, receptors, transporters, and many other types of molecules, in addition to the muscle tissues or the egg white we refer to as protein. In this write up, protein refers to those other molecules and not to fried chicken.

It is paradoxical that the biological mechanisms responsible for cancer are also integral to human existence. Without these processes, humans would not be able to inhabit the Earth. Cancer is a byproduct of this process that has been going on for the past 3.8 to 4.1 billion years, resulting in the vast diversity of life. It is necessary to delve into the inner working of DNA and proteins to see how it happens.

DNA is a polymer, meaning it is made up of repeated units called nucleotides. Each nucleotide contains a nitrogenous base, a five-carbon sugar, and a phosphate group. There are four nucleotides in DNA: adenine (A), thymine (T), guanine (G), and cytosine (C). Those studying for the O/L exam will protest by saying there are five. Yes, but let us leave uracil (U) and RNA aside for the time being, even though they, too, have a role to play.

Image credit Statista

The instructions set in our ‘manual’ are written in ‘code’ using the four nucleotides as ‘letters’ A, T, G and C. The words in this code have only three letters, which are called codons. The sentences are called genes. Each human cell has about three billion letters, and approximately twenty thousand sentences. The adult body has about thirty trillion cells; un unfathomable number. Like everything else, cells have a limited lifetime. Of those thirty trillion cells, about three hundred billion cells die every minute, and they must be replaced continuously to maintain the body. Both cell death (apoptosis) and cell division are highly regulated to ensure the balance. When either of these two processes become dysregulated and unwanted cells begin to accumulate, that condition is called cancer. Dysregulation can happen in diverse ways.

Proteins are polymers of amino acids; they are like ropes and can be folded into different shapes. Most importantly, the three-dimensional shape determines what a protein can do. The fundamental rule of protein biochemistry is amino acid sequence decides the shape and shape determines the function of the protein. The folding of the protein chains into the required shape is assisted by chaperones, which are proteins themselves.

Every time a cell divides, its DNA or the entire instruction manual must be copied and passed on to the two daughter cells. Who does the copying? You got it, proteins. In addition, there are readers, translators, writers, and thousands of other ‘workers’ who perform various duties. There are proofreaders, editors, and supervisors, as well, to make sure that everything is done according to the instructions. However, considering the enormous amount of work and frequency in which it occurs, a few mistakes go undetected. These mistakes are called mutations.

Mutations, which are akin to typing errors, change the meaning of the sentence involved, i.e., the gene. It results in an amino acid sequence that is different from the intended one. When this happens, one of three things can happen. First, despite the difference, it can fold into the same shape as the regular protein and continue to do its work without change. Second, the new shape fails to do the work, in that case the cell will die, and the mutation will be eliminated from propagating. The third one is the most consequential. If the new protein is better than the regular one in doing the job or can do a new job that is beneficial to the cell, that cell gains a survival advantage over the other cells.

If this advantageous mutation occurred in germ cells, and if it was passed on to the progeny, it sets off a particularly important process. Since it gives a survival advantage over the unmutated in facing a changing environment, for example, over time, they will evolve into a new species. And the unmutated, failing to adapt, will become obsolete. However, these types of mutations are rare, the reason evolution is so slow.

If the improved or new function involves promoting cell division, it becomes a potential disaster. There are proteins that detect unusual or uncontrollably dividing cells and remove them. Those killer proteins belong to the immune system and are called antibodies. However, if the proliferation rate is greater than what the immune system can manage, cells accumulate and become cancerous. If the cancer is localised, i.e., grows in a restricted area and does not spread, it is called a benign tumor. Unless they overcrowd a vital organ, such the brain, they can be harmless. On the other hand, if the cells spread uncontrollably and invade other organs, i.e., metastasis, which can be a life-threatening situation. If the responsible mutation occurred in germ cells, there is a possibility that the trait be transmitted to the progeny. Fortunately, genetically transmitted cancers are less than 10 percent of the detected cancers – in biological terms, DNA mutations are lower than transcription errors.

There are other ways that proteins can become unregulated due to environmental factors. The exposure to radiation and chemicals, known as carcinogens, can change the chemical structure of nucleotides, or the letters of the code itself. There are other environmental agents that can directly attach or react with proteins and change shape, thereby altering their function. This is also a necessary feature of proteins that allow their function to be turned on and off as needed. For example, when cell division is in progress, the essential proteins can be turned on or off by changing their shape by either attaching a phosphate group or remove an existing one. Some carcinogenic agents can attach to the protein permanently, thereby locking it in either on or off mode, leading to disaster.

Now let us turn to cancer prevention. There is no known way to prevent the cells from making copying errors. Considering the odds against it, the system is doing a miraculous job in minimizing errors. Even if it is possible, doing so would deprive the distant future generation from adapting to environmental challenges. Minimizing exposure to potential carcinogenic agents is the option, but industrial revolution and modern lifestyles make it a mighty challenge. Human activity keeps adding more potentially carcinogenic agents to the environment. The International Agency for Research on Cancer lists 133 carcinogenic agents and 418 likely carcinogenic agents that humans encounter under various conditions (Monograph volume 100).

Some common examples are alcohol in beverages, benzene in petrol, formaldehyde found in many household products, aflatoxins in contaminated foods, diesel engine exhaust, coal plant emissions, and processed meat. Food items laced with herbicides and insecticides and grilled and fried red meat can be added to the list. Unfortunately, hepatitis and human papilloma virus infections also increase the risk of cancer.

There is another unsuspecting agent that is posing increasing risks: plastics. Often, food and drinks are contaminated with carcinogenic additives used in the manufacture of their plastic packaging. In addition, microplastics, the tiny particles produced when plastics breakdown, are found in antarctica to breast milk to brain tissues. They have been linked to a plethora of chronic ailments including cancer (S. Goswami and others, 2024). Since it is difficult to foresee a way to clean up this widespread and disastrous plastic contamination, this will be a problem that humanity is destined to battle in eternity.

As far as cancer eradication goes, that is a gloomy picture. But there is hope. There are ways to minimise the risk of cancer, which depends on several factors: how bad the carcinogen (hazard level) and the duration of exposure. The lifestyle also matters. There are reliable sources where helpful information on cancer risk assessment and on preventive measures are available. World Health Organisation (https://www.who.int/activities/preventing-cancer) and American Cancer Society (https://acscancerrisk360.cancer.org/) are two examples. The worldwide cancer incidents have been increasing; however, at the same time, the cancer death rate has been declining. That is thanks to early detection and improved treatment methods; those are topics for discussion at another time.

by Geewananda Gunawardana, Ph.D.



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Rethinking post-disaster urban planning: Lessons from Peradeniya

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University of Peradeniya

A recent discussion by former Environment Minister, Eng. Patali Champika Ranawaka on the Derana 360 programme has reignited an important national conversation on how Sri Lanka plans, builds and rebuilds in the face of recurring disasters.

His observations, delivered with characteristic clarity and logic, went beyond the immediate causes of recent calamities and focused sharply on long-term solutions—particularly the urgent need for smarter land use and vertical housing development.

Ranawaka’s proposal to introduce multistoried housing schemes in the Gannoruwa area, as a way of reducing pressure on environmentally sensitive and disaster-prone zones, resonated strongly with urban planners and environmentalists alike.

It also echoed ideas that have been quietly discussed within academic and conservation circles for years but rarely translated into policy.

One such voice is that of Professor Siril Wijesundara, Research Professor at the National Institute of Fundamental Studies (NIFS) and former Director General of the Royal Botanic Gardens, Peradeniya, who believes that disasters are often “less acts of nature and more outcomes of poor planning.”

Professor Siril Wijesundara

“What we repeatedly see in Sri Lanka is not merely natural disasters, but planning failures,” Professor Wijesundara told The Island.

“Floods, landslides and environmental degradation are intensified because we continue to build horizontally, encroaching on wetlands, forest margins and river reservations, instead of thinking vertically and strategically.”

The former Director General notes that the University of Peradeniya itself offers a compelling case study of both the problem and the solution. The main campus, already densely built and ecologically sensitive, continues to absorb new faculties, hostels and administrative buildings, placing immense pressure on green spaces and drainage systems.

“The Peradeniya campus was designed with landscape harmony in mind,” he said. “But over time, ad-hoc construction has compromised that vision. If development continues in the same manner, the campus will lose not only its aesthetic value but also its ecological resilience.”

Professor Wijesundara supports the idea of reorganising the Rajawatte area—located away from the congested core of the university—as a future development zone. Rather than expanding inward and fragmenting remaining open spaces, he argues that Rajawatte can be planned as a well-designed extension, integrating academic, residential and service infrastructure in a controlled manner.

Crucially, he stresses that such reorganisation must go hand in hand with social responsibility, particularly towards minor staff currently living in the Rajawatte area.

“These workers are the backbone of the university. Any development plan must ensure their dignity and wellbeing,” he said. “Providing them with modern, safe and affordable multistoried housing—especially near the railway line close to the old USO premises—would be both humane and practical.”

According to Professor Wijesundara, housing complexes built near existing transport corridors would reduce daily commuting stress, minimise traffic within the campus, and free up valuable land for planned academic use.

More importantly, vertical housing would significantly reduce the university’s physical footprint.

Drawing parallels with Ranawaka’s Gannoruwa proposal, he emphasised that vertical development is no longer optional for Sri Lanka.

“We are a small island with a growing population and shrinking safe land,” he warned.

“If we continue to spread out instead of building up, disasters will become more frequent and more deadly. Vertical housing, when done properly, is environmentally sound, economically efficient and socially just.”

Peradeniya University flooded

The veteran botanist also highlighted the often-ignored link between disaster vulnerability and the destruction of green buffers.

“Every time we clear a lowland, a wetland or a forest patch for construction, we remove nature’s shock absorbers,” he said.

“The Royal Botanic Gardens has survived floods for over a century precisely because surrounding landscapes once absorbed excess water. Urban planning must learn from such ecological wisdom.”

Professor Wijesundara believes that universities, as centres of knowledge, should lead by example.

“If an institution like Peradeniya cannot demonstrate sustainable planning, how can we expect cities to do so?” he asked. “This is an opportunity to show that development and conservation are not enemies, but partners.”

As climate-induced disasters intensify across the country, voices like his—and proposals such as those articulated by Patali Champika Ranawaka—underscore a simple but urgent truth: Sri Lanka’s future safety depends not only on disaster response, but on how and where we build today.

The challenge now lies with policymakers and planners to move beyond television studio discussions and academic warnings, and translate these ideas into concrete, people-centred action.

By Ifham Nizam ✍️

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Superstition – Major barrier to learning and social advancement

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At the initial stage of my six-year involvement in uplifting society through skill-based initiatives, particularly by promoting handicraft work and teaching students to think creatively and independently, my efforts were partially jeopardized by deep-rooted superstition and resistance to rational learning.

Superstitions exerted a deeply adverse impact by encouraging unquestioned belief, fear, and blind conformity instead of reasoning and evidence-based understanding. In society, superstition often sustains harmful practices, social discrimination, exploitation by self-styled godmen, and resistance to scientific or social reforms, thereby weakening rational decision-making and slowing progress. When such beliefs penetrate the educational environment, students gradually lose the habit of asking “why” and “how,” accepting explanations based on fate, omens, or divine intervention rather than observation and logic.

Initially, learners became hesitant to challenge me despite my wrong interpretation of any law, less capable of evaluating information critically, and more vulnerable to misinformation and pseudoscience. As a result, genuine efforts towards social upliftment were obstructed, and the transformative power of education, which could empower individuals economically and intellectually, was weakened by fear-driven beliefs that stood in direct opposition to progress and rational thought. In many communities, illnesses are still attributed to evil spirits or curses rather than treated as medical conditions. I have witnessed educated people postponing important decisions, marriages, journeys, even hospital admissions, because an astrologer predicted an “inauspicious” time, showing how fear governs rational minds.

While teaching students science and mathematics, I have clearly observed how superstition acts as a hidden barrier to learning, critical thinking, and intellectual confidence. Many students come to the classroom already conditioned to believe that success or failure depends on luck, planetary positions, or divine favour rather than effort, practice, and understanding, which directly contradicts the scientific spirit. I have seen students hesitate to perform experiments or solve numerical problems on certain “inauspicious” days.

In mathematics, some students label themselves as “weak by birth”, which creates fear and anxiety even before attempting a problem, turning a subject of logic into a source of emotional stress. In science classes, explanations based on natural laws sometimes clash with supernatural beliefs, and students struggle to accept evidence because it challenges what they were taught at home or in society. This conflict confuses young minds and prevents them from fully trusting experimentation, data, and proof.

Worse still, superstition nurtures dependency; students wait for miracles instead of practising problem-solving, revision, and conceptual clarity. Over time, this mindset damages curiosity, reduces confidence, and limits innovation, making science and mathematics appear difficult, frightening, or irrelevant. Many science teachers themselves do not sufficiently emphasise the need to question or ignore such irrational beliefs and often remain limited to textbook facts and exam-oriented learning, leaving little space to challenge superstition directly. When teachers avoid discussing superstition, they unintentionally reinforce the idea that scientific reasoning and superstitious beliefs can coexist.

To overcome superstition and effectively impose critical thinking among students, I have inculcated the process to create a classroom culture where questioning was encouraged and fear of being “wrong” was removed. Students were taught how to think, not what to think, by consistently using the scientific method—observation, hypothesis, experimentation, evidence, and conclusion—in both science and mathematics lessons. I have deliberately challenged superstitious beliefs through simple demonstrations and hands-on experiments that allow students to see cause-and-effect relationships for themselves, helping them replace belief with proof.

Many so-called “tantrik shows” that appear supernatural can be clearly explained and exposed through basic scientific principles, making them powerful tools to fight superstition among students. For example, acts where a tantrik places a hand or tongue briefly in fire without injury rely on short contact time, moisture on the skin, or low heat transfer from alcohol-based flames rather than divine power.

“Miracles” like ash or oil repeatedly appearing from hands or idols involve concealment or simple physical and chemical tricks. When these tricks are demonstrated openly in classrooms or science programmes and followed by clear scientific explanations, students quickly realise how easily perception can be deceived and why evidence, experimentation, and critical questioning are far more reliable than blind belief.

Linking concepts to daily life, such as explaining probability to counter ideas of luck, or biology to explain illness instead of supernatural causes, makes rational explanations relatable and convincing.

Another unique example that I faced in my life is presented here. About 10 years ago, when I entered my new house but did not organise traditional rituals that many consider essential for peace and prosperity as my relatives believed that without them prosperity would be blocked.  Later on, I could not utilise the entire space of my newly purchased house for earning money, largely because I chose not to perform certain rituals.

While this decision may have limited my financial gains to some extent, I do not consider it a failure in the true sense. I feel deeply satisfied that my son and daughter have received proper education and are now well settled in their employment, which, to me, is a far greater achievement than any ritual-driven expectation of wealth. My belief has always been that a house should not merely be a source of income or superstition-bound anxiety, but a space with social purpose.

Instead of rituals, I strongly feel that the unused portion of my house should be devoted to running tutorials for poor and underprivileged students, where knowledge, critical thinking, and self-reliance can be nurtured. This conviction gives me inner peace and reinforces my faith that education and service to society are more meaningful measures of success than material profit alone.

Though I have succeeded to some extent, this success has not been complete due to the persistent influence of superstition.

by Dr Debapriya Mukherjee
Former Senior Scientist
Central Pollution Control Board, India ✍️

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Race hate and the need to re-visit the ‘Clash of Civilizations’

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Australian Prime Minister Anthony Albanese: ‘No to race hate’

Australian Prime Minister Anthony Albanese has done very well to speak-up against and outlaw race hate in the immediate aftermath of the recent cold-blooded gunning down of several civilians on Australia’s Bondi Beach. The perpetrators of the violence are believed to be ardent practitioners of religious and race hate and it is commendable that the Australian authorities have lost no time in clearly and unambiguously stating their opposition to the dastardly crimes in question.

The Australian Prime Minister is on record as stating in this connection: ‘ New laws will target those who spread hate, division and radicalization. The Home Affairs Minister will also be given new powers to cancel or refuse visas for those who spread hate and a new taskforce will be set up to ensure the education system prevents, tackles and properly responds to antisemitism.’

It is this promptness and single-mindedness to defeat race hate and other forms of identity-based animosities that are expected of democratic governments in particular world wide. For example, is Sri Lanka’s NPP government willing to follow the Australian example? To put the record straight, no past governments of Sri Lanka initiated concrete measures to stamp out the evil of race hate as well but the present Sri Lankan government which has pledged to end ethnic animosities needs to think and act vastly differently. Democratic and progressive opinion in Sri Lanka is waiting expectantly for the NPP government’ s positive response; ideally based on the Australian precedent to end race hate.

Meanwhile, it is apt to remember that inasmuch as those forces of terrorism that target white communities world wide need to be put down their counterpart forces among extremist whites need to be defeated as well. There could be no double standards on this divisive question of quashing race and religious hate, among democratic governments.

The question is invariably bound up with the matter of expeditiously and swiftly advancing democratic development in divided societies. To the extent to which a body politic is genuinely democratized, to the same degree would identity based animosities be effectively managed and even resolved once and for all. To the extent to which a society is deprived of democratic governance, correctly understood, to the same extent would it experience unmanageable identity-bred violence.

This has been Sri Lanka’s situation and generally it could be stated that it is to the degree to which Sri Lankan citizens are genuinely constitutionally empowered that the issue of race hate in their midst would prove manageable. Accordingly, democratic development is the pressing need.

While the dramatic blood-letting on Bondi Beach ought to have driven home to observers and commentators of world politics that the international community is yet to make any concrete progress in the direction of laying the basis for an end to identity-based extremism, the event should also impress on all concerned quarters that continued failure to address the matters at hand could prove fatal. The fact of the matter is that identity-based extremism is very much alive and well and that it could strike devastatingly at a time and place of its choosing.

It is yet premature for the commentator to agree with US political scientist Samuel P. Huntingdon that a ‘Clash of Civilizations’ is upon the world but events such as the Bondi Beach terror and the continuing abduction of scores of school girls by IS-related outfits, for instance, in Northern Africa are concrete evidence of the continuing pervasive presence of identity-based extremism in the global South.

As a matter of great interest it needs mentioning that the crumbling of the Cold War in the West in the early nineties of the last century and the explosive emergence of identity-based violence world wide around that time essentially impelled Huntingdon to propound the hypothesis that the world was seeing the emergence of a ‘Clash of Civilizations’. Basically, the latter phrase implied that the Cold War was replaced by a West versus militant religious fundamentalism division or polarity world wide. Instead of the USSR and its satellites, the West, led by the US, had to now do battle with religion and race-based militant extremism, particularly ‘Islamic fundamentalist violence’ .

Things, of course, came to a head in this regard when the 9/11 calamity centred in New York occurred. The event seemed to be startling proof that the world was indeed faced with a ‘Clash of Civilizations’ that was not easily resolvable. It was a case of ‘Islamic militant fundamentalism’ facing the great bulwark, so to speak, of ‘ Western Civilization’ epitomized by the US and leaving it almost helpless.

However, it was too early to write off the US’ capability to respond, although it did not do so by the best means. Instead, it replied with military interventions, for example, in Iraq and Afghanistan, which moves have only earned for the religious fundamentalists more and more recruits.

Yet, it is too early to speak in terms of a ‘Clash of Civilizations’. Such a phenomenon could be spoken of if only the entirety of the Islamic world took up arms against the West. Clearly, this is not so because the majority of the adherents of Islam are peaceably inclined and want to coexist harmoniously with the rest of the world.

However, it is not too late for the US to stop religious fundamentalism in its tracks. It, for instance, could implement concrete measures to end the blood-letting in the Middle East. Of the first importance is to end the suffering of the Palestinians by keeping a tight leash on the Israeli Right and by making good its boast of rebuilding the Gaza swiftly.

Besides, the US needs to make it a priority aim to foster democratic development worldwide in collaboration with the rest of the West. Military expenditure and the arms race should be considered of secondary importance and the process of distributing development assistance in the South brought to the forefront of its global development agenda, if there is one.

If the fire-breathing religious demagogue’s influence is to be blunted worldwide, then, it is development, understood to mean equitable growth, that needs to be fostered and consolidated by the democratic world. In other words, the priority ought to be the empowerment of individuals and communities. Nothing short of the latter measures would help in ushering a more peaceful world.

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