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Scientists discover a new, unexpected way that cancer cells spread
One of the challenges in treating cancer is stopping it from metastasizing and a new study reveals one of the fundamental mechanisms through which this happens. Now we know about this mechanism, perhaps we can stop it, according to a report published by Science Alert.
The report filed by David Nield says the key to this newly discovered process is GRP78, and it’s what’s known as a chaperone protein. It’s a type of protein that lends a hand in the folding or unfolding of larger proteins, basically building them up (or tearing them down), which then affects whether they’re biologically active and functional.
“A team led by the Keck School of Medicine at the University of Southern California (USC) in the US found that cancer cells can hijack GRP78, using the protein to spread further in the body and resist treatment.
This appears to happen because the protein migrates when under stress. GRP78 is usually found in the endoplasmic reticulum part of a cell, but this research shows it moving to the nucleus and changing the cell behavior.
“Seeing GRP78 in the nucleus controlling gene expression is a total surprise,” says Amy Lee, a biochemist and molecular biologist at USC.
“When it comes to the basic mechanisms of cancer cells, this is something novel that, to my knowledge, no one has observed before.”
“The discovery came about by analyzing how GRP78 regulates the gene EGFR, previously linked with cancer. Advanced 2D and 3D imaging techniques – including confocal microscopy, where separate beams of light are used to increase resolutions, were used to confirm the migration of GRP78.
“Cells with (top row) and without (bottom row) GRP78 – blue shows the nucleus, green shows cytoskeletal protein. (Ze Liu/Amy Lee)
“Further methods, including RNA sequencing (taking a snapshot of cell activity), were then used to get a closer look at what the GRP78 protein was actually doing. It turns out that the key genes it was regulating were involved in cell migration and invasion.
“Another important discovery made by the researchers was how GRP78 binds or interacts with another cellular protein, ID2. It seems that GRP78 stops ID2 from doing its regular job, which is limiting the activity of genes involved in cell migration, including EGFR.
“While this might all seem very technical, once scientists understand how proteins like GRP78 operate regarding cancer metastasis, they can start thinking about ways to control them. By stopping GRP78 from moving around or blocking ID2, for example, we might be able to prevent cancer cells from spreading.
“Getting to that stage will require a lot more research, but discoveries are being made on a regular basis when it comes to cancer growth – whether that’s how they get into the blood or spread to the bones.
“This is a new concept,” says Lee. “The protein itself is the soldier that does the job, but now we’re thinking it’s not just about the soldier, but also where the soldier is deployed.”
The research has been published in PNAS.
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Promoting Local Industries is a key priority of the Government – PM
Prime Minister Dr. Harini Amarasuriya stated that promoting the local industrial sector is one of the key priorities of the Government.
The Prime Minister made these remarks while attending the official opening ceremony of the INCO 2026 Industrial Exhibition on 13 th of March, which is being held for the 20th consecutive year at the BMICH Exhibition Center.
The INCO 2026 Industrial Exhibition, organized by the Institution of Incorporated Engineers, Sri Lanka (IIESL), will be held from March 13 to 15.
Addressing at the event, Prime Minister stated:
“The engineering sector is a key driving force in addressing practical challenges faced by a country while enhancing efficiency and safety. In particular, the contribution extended by exhibitions of this nature encourages the student community to engage in innovation.
The Government has implemented several measures to accelerate the country’s industrial development. Notably, the National Industry Information System (NIIS) has established a centralized digital platform to collect data related to the country’s economic and industrial activities. The Government is also taking steps to provide necessary financial support to industrialists through Revolving Funds.
It is also noteworthy that this year’s exhibition has attracted international participation, creating opportunities for local entrepreneurs to explore new markets and gain exposure to international technologies. With the participation of engineers, students, and entrepreneurs, this exhibition marks an important step toward the country’s industrial future”.
The event was attended by the Chairman of the Export Development Board Mangala Wijesinghe, Chairman of the National Paper Company Limited Upali Rathnayake, President of the Institution of Incorporated Engineers, Sri Lanka Engineer Ananda Gunawardena, along with local and foreign investors, entrepreneurs, and industrialists.

(Prime Minister’s Media Division)
News
Crypto loopholes funnel Lankan funds abroad
Chief Magistrate draws CB attention to massive drain in foreign exchange through cryptocurrency deals
Colombo Chief Magistrate Asanga S. Bodaragama yesterday observed that loopholes in actions carried out by State financial institutions, under the Foreign Exchange Act, had enabled funds in Sri Lanka to be transferred overseas, through cryptocurrency transactions.
The Magistrate said immediate steps should be taken to curb such activities and to educate the public, and directed that the matter be brought to the attention of the Central Bank of Sri Lanka.
He noted that cryptocurrency transactions carried out, using modern technology without approval from the Central Bank, had taken place without adequate public awareness, adding that incidents of the nature were increasingly being reported before courts.
The Magistrate observed that investigations into such incidents appeared to be confined to court proceedings alone and emphasised that the Central Bank, as the country’s principal financial regulator, together with other relevant institutions, should take appropriate measures and raise public awareness in the interest of the public and the country.
He also said the Criminal Investigation Department and the Central Bank should take steps to educate the public on such financial frauds and introduce a proper mechanism to address the issue.
The court further observed that many individuals had exploited loopholes in the Foreign Exchange Act and related procedures to commit financial fraud, and stressed that the Central Bank should take necessary action upon being apprised of such matters.
The Magistrate made these observations when a case relating to an alleged Rs. 290 million fraud at a well-known private bank was taken up before court yesterday. The suspects are alleged to have fraudulently obtained public funds through cryptocurrency transactions using accounts on Binance.
The Magistrate also directed the Criminal Investigation Department to expedite investigations into the disappearance of Rs. 290 million and report progress to court.Observing that the incident was not an ordinary case, the Magistrate instructed the CID to take prompt action to prevent similar frauds carried out through Binance platforms.
Making further observations, the Magistrate noted that the suspects had been produced before court, over the past three months, in connection with the incident, and stressed that investigations should be completed promptly by gathering all relevant information.
He earlier observed that the case did not involve a minor offence, such as ordinary theft, but a serious matter concerning the fraudulent misappropriation of public funds, through Binance accounts, and emphasised the need for swift action to prevent such crimes.
Nineteen suspects, connected to the incident, had earlier been remanded and subsequently released on bail.
The case was fixed to be called again on 15 May .
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SLCERT urges Lankans not to get gypped by internet scams in run-up to festive period
The Sri Lanka Computer Emergency Readiness Team (SLCERT) has issued a public advisory urging internet users to exercise caution when engaging with online advertisements in the run-up to the festive season.
Senior Information Security Engineer at SLCERT, Charuka Damunupola, said that several incidents of online scams had already been reported to the organisation during the first two months of this year.
He warned that with the approaching Sinhala and Tamil New Year, the risk of fraudulent advertisements and malicious links, appearing online, was likely to increase, often disguised as discount offers, cash prizes, or special promotional deals.
Damunupola noted that such links frequently redirect users to fraudulent websites designed to harvest personal information and other sensitive data.
He further cautioned that during the Vesak and Poson festive periods, scammers may attempt to collect user data through deceptive schemes promoted under various guises, including campaigns such as ‘Poson Maha Data Dansala.’
SLCERT has, therefore, urged the public to remain vigilant and exercise caution when clicking on unsolicited links or advertisements encountered online.
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