News
Scientists discover a new, unexpected way that cancer cells spread

One of the challenges in treating cancer is stopping it from metastasizing and a new study reveals one of the fundamental mechanisms through which this happens. Now we know about this mechanism, perhaps we can stop it, according to a report published by Science Alert.
The report filed by David Nield says the key to this newly discovered process is GRP78, and it’s what’s known as a chaperone protein. It’s a type of protein that lends a hand in the folding or unfolding of larger proteins, basically building them up (or tearing them down), which then affects whether they’re biologically active and functional.
“A team led by the Keck School of Medicine at the University of Southern California (USC) in the US found that cancer cells can hijack GRP78, using the protein to spread further in the body and resist treatment.
This appears to happen because the protein migrates when under stress. GRP78 is usually found in the endoplasmic reticulum part of a cell, but this research shows it moving to the nucleus and changing the cell behavior.
“Seeing GRP78 in the nucleus controlling gene expression is a total surprise,” says Amy Lee, a biochemist and molecular biologist at USC.
“When it comes to the basic mechanisms of cancer cells, this is something novel that, to my knowledge, no one has observed before.”
“The discovery came about by analyzing how GRP78 regulates the gene EGFR, previously linked with cancer. Advanced 2D and 3D imaging techniques – including confocal microscopy, where separate beams of light are used to increase resolutions, were used to confirm the migration of GRP78.
“Cells with (top row) and without (bottom row) GRP78 – blue shows the nucleus, green shows cytoskeletal protein. (Ze Liu/Amy Lee)
“Further methods, including RNA sequencing (taking a snapshot of cell activity), were then used to get a closer look at what the GRP78 protein was actually doing. It turns out that the key genes it was regulating were involved in cell migration and invasion.
“Another important discovery made by the researchers was how GRP78 binds or interacts with another cellular protein, ID2. It seems that GRP78 stops ID2 from doing its regular job, which is limiting the activity of genes involved in cell migration, including EGFR.
“While this might all seem very technical, once scientists understand how proteins like GRP78 operate regarding cancer metastasis, they can start thinking about ways to control them. By stopping GRP78 from moving around or blocking ID2, for example, we might be able to prevent cancer cells from spreading.
“Getting to that stage will require a lot more research, but discoveries are being made on a regular basis when it comes to cancer growth – whether that’s how they get into the blood or spread to the bones.
“This is a new concept,” says Lee. “The protein itself is the soldier that does the job, but now we’re thinking it’s not just about the soldier, but also where the soldier is deployed.”
The research has been published in PNAS.
News
New education reforms are not only to align education with job market demands but also to cultivate skilled youth who can contribute to the economy and provide leadership to society -Prime Minister

As part of the series of programmes conducted for schoolchildren by the Presidential Secretariat, the Ministry of Education and the Sri Lanka Parliament Department of Communication, a special Student Parliament session for Visakha Vidyalaya, Colombo, was held on Tuesday (25) at the Old Parliament Chamber of the Presidential Secretariat. The event was conducted under the patronage of Prime Minister Dr. Harini Amarasuriya.
During the session, the student parliament members of Visakha Vidyalaya had the opportunity to gain insights into the conceptual and practical significance of the “Clean Sri Lanka” initiative.
A special commemorative edition of the ‘Vision’ magazine, which focuses on the student Parliament initiative, was presented to the Prime Minister by Nadeeka Dangolla, Assistant Director of Parliamentary Affairs and Executive Functions.
Furthermore, the Principal of Visakha Vidyalaya, Mrs. Manomi Seneviratne, presented a special commemorative token to the Prime Minister.
Addressing the gathering, Prime Minister Dr. Harini Amarasuriya highlighted that the government’s commitment to implementing new educational reforms aimed at nurturing a generation capable of seizing economic opportunities.
The Prime Minister further stated that the government aims to prepare Sri Lankan children to acquire global knowledge while fostering a self-reliant and empowered future generation.
The Prime Minister stated that the objective of the new education reforms are not only to align education with job market demands but also to cultivate skilled youth who can contribute to the economy and provide leadership to society.
Furthermore, she underscored the government’s commitment to addressing resource disparities among schools and emphasized the significance of civic responsibility in this endeavour.
Speaker Dr. Jagath Wickramaratne:
‘Leadership must be devoid of selfishness. Selfless leaders guide both the nation and its people towards a better direction. To achieve this, skills must be enhanced. We can learn about talented leaders from both Sri Lankan history and global history. We should study as children how Chandashoka transformed into Dharmashoka and how Hitler’s regime brought devastation to the world. A nation achieves stability when leaders who prioritize minimal personal consumption and demonstrate a true dedication to their nation arise. Therefore, we must strive to cultivate leaders who can face challenges and prioritize national interests. By fostering selflessness, we can ensure a prosperous future for our people.’
Senior Presidential Media Advisor Mr. Chandana Sooriyabandara:
‘The students gathered here today are not just future leaders; they are leaders already. Leadership knows no age. Anyone who stands for a group could be consider as a leader. Those who exercise the power of the group are considered leaders. Throughout Sri Lankan history, individuals who contributed to the country through their words and actions have played leadership roles. Therefore, logical reasoning should lead the process of making decisions. Both leaders and citizens share the duty to act rationally. You all have a duty to shape a prosperous nation through logical thinking, and this obligation lies with every young person.’
The event was also attended by Deputy Speaker Dr. Rizvie Salih, Deputy Chairperson of Committees Hemali Weerasekara, Secretary-General of the Parliament Kushani Rohanadeera, Senior Additional Secretary to the President K.M.N. Kumarasinghe, Director-General of Legal Affairs to the President J.M. Wijebandara, Principal of Visakha Vidyalaya Manomi Seneviratne, along with members of the teaching staff and a group of students.
News
UK sanctions: MR urges govt. to stand by military

Former President Mahinda Rajapaksa has urged the NPP government to stand by Sri Lanka’s war-winning military. The following is the text of the statement issued by the former President: “The United Kingdom govt. has announced sanctions, including travel bans and asset freezes, against Sri Lanka’s former Chief of Defence Staff Shavendra Silva, former Navy Commander Wasantha Karannagoda and former Army Commander Jagath Jayasuriya over unproven allegations of human rights violations during the war with the LTTE. It was I, as the Executive President of Sri Lanka, who took the decision to militarily defeat the LTTE and the armed forces implemented that decision on the ground.
Despite the 2002 ceasefire agreement, the LTTE had carried out 363 killings during the ceasefire between February 2002 and the end of September 2005. LTTE attacks intensified in the first few weeks and months after I was elected President in November 2005. Among the most serious such incidents were claymore mine attacks on 4 and 6 December 2005 in Jaffna that killed 13 soldiers, a suicide attack on a naval craft on 5 January 2006 that killed 15 naval personnel, and the suicide attack on the Army Commander inside Army Headquarters in April 2006.
Despite all that, my government held two rounds of peace talks in January and June 2006, in Geneva and Oslo, which were unilaterally halted by the LTTE. The LTTE landmine attack on a civilian bus in Kebithogollawa in June 2006 which killed 64 and seriously injured 86, many of them children – was a pivotal moment for me and my govt. Military operations commenced in July 2006 when the LTTE closed the Mawilaru anicut, cutting off irrigation water to cultivators in the Trincomalee district, and did not stop until the LTTE was completely defeated on 19 May 2009.
I categorically reject the UK govt.’s allegation of widespread human rights violations during the military operations. Lord Naseby stated in the House of Lords on 12 October 2017 that the then UK Defence Attache in Colombo Lieutenant Colonel Anton Gash had in conversation with him, praised the discipline of the Sri Lanka Army and stated that there certainly was no policy to kill civilians. Because Lt. Col Anton Gash’s war time dispatches to London differ so significantly from the narrative promoted by the UK political authorities, only a heavily redacted version of those dispatches have been released. We conducted military operations only against the LTTE and not against the Tamil people.
Just months after the war ended, when my wartime Army commander came forward as the Opposition candidate at the 2010 presidential elections, the Tamil National Alliance issued a statement on 6 January 2010 appealing to the Tamil people to vote for the former Army commander and he won over 60% of the votes cast in the Northern and Eastern Provinces, thus directly contradicting the narrative being promoted by the UK govt. Imposing sanctions on Vinayagamoorthy Muralitharan, aka Karuna Amman, who broke away from the LTTE, in 2004, and later entered democratic politics, is a clear case of penalizing anti-LTTE Tamils so as to placate the dominant segment of the Tamil diaspora in the UK.
When the UK Foreign Secretary David Milliband came to Sri Lanka, in April 2009, and demanded a halt to military operations, I flatly turned him down. Later, a London-based newspaper The Telegraph revealed – quoting secret documents made public by Wikileaks – that Mr. Miliband had tried to intervene in Sri Lanka to win Tamil votes for the Labour Party. Regrettably, to this day, vote bank politics determines the UK’s stand on Sri Lanka’s war against the LTTE.
Three decades of LTTE terrorism claimed the lives of 27,965 armed forces and police personnel not to mention the lives of many thousands of civilians, including politicians. What Sri Lanka defeated in 2009 was the organization that the US Federal Bureau of Investigation had officially designated as the deadliest terrorist organization in the world. It is noteworthy that the United Kingdom introduced special legislation in 2021 and 2023 to protect their own armed forces from persecution by interested parties.
Hence I expect the present government to resolutely stand by and defend former armed forces personnel who face persecution by foreign governments and organisations for doing their duty to safeguard Sri Lanka’s national security.”
News
Jet crash: Deputy Defence Minister, too, contradicts Minister Ratnayake

Deputy Defence Minister Maj. Gen. (Retd) Aruna Jayasekera, on Tuesday (25), said that Air Force investigation into the 21 March K-8 advanced jet crash had not been concluded.
Jayasekera was responding to a media query. The media sought the Maj. Gen’s comments in the wake of Transport Minister and Leader of the House Bimal Ratnayake’s declaration that the crash had been caused by pilot error.
The Air Force Headquarters has already contradicted Minister Ratnayake’s unsubstantiated claim. The qualified instructor and the trainee ejected before the ill-fated aircraft, attached to the Katunayake-based No 05 squadron, crashed at Wariyapola.
-
Business6 days ago
Cargoserv Shipping partners Prima Ceylon & onboards Nestlé Lanka for landmark rail logistics initiative
-
News4 days ago
Seniors welcome three percent increase in deposit rates
-
Features4 days ago
The US, Israel, Palestine, and Mahmoud Khalil
-
Business6 days ago
Sri Lankans Vote Dialog as the Telecommunication Brand and Service Brand of the Year
-
News4 days ago
Scholarships for children of estate workers now open
-
News5 days ago
Defence Ministry of Japan Delegation visits Pathfinder Foundation
-
Features6 days ago
The Vaping Veil: Unmasking the dangers of E-Cigarettes
-
News6 days ago
‘Deshabandu is on SLC payroll’; Hesha tables documents