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Immunity Blackout: The Conundrum of ‘Immune Amnesia’ in Humans

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Just visualise the scenario where you spend years of your life building up a defence team in your body that remembers every invading enemy it has fought, from chickenpox to the flu, from pneumonia to skin infections and many, many, more. The body then goes on to build up a robust armamentarium to fight them the next time they attempt to cause trouble. This is what usually happens with our natural defence systems of the human body. The memory of the attackers is the thing that leads to war being declared on them subsequently.

Now, imagine a setting where disaster strikes in the form of some intruder who breaks in and erases those memories, leaving your body exposed and unprotected. We now know for sure that this is not a scene from a science fiction movie. It is a real thing that takes place in the human body, called Immune Amnesia; the word amnesia being a glorified term for forgetting something. It is a situation where the body “disremembers” how to fight off diseases it once defeated. This kind of immune memory loss leaves the body wide open to catching infections that one was previously protected against. It is not merely about getting sick again. It is about becoming vulnerable to a whole list of diseases, some of them serious, or even deadly.

The human immune system is like an army that defends the body against harmful invaders like bacteria and viruses. It has two main parts. One is the Innate Immune System, the first line of defence, a quick response team that is inherent in humans, which attacks anything unfamiliar. Humans are born with the capacity to direct this Innate Immune System to respond unreservedly to any harmful agent that invades the body. The second line of resistance of the human defensive army is the Adaptive Immune System, which is the smarter component that specifically remembers past infections and builds explicit and precise weapons to fight them off more efficiently when the perpetrators try to attack the body a second time. These weapons include antibodies and immune memory cells. Thanks to this adaptive immune system, if you had chickenpox as a child, your body remembers how to fight it. That is why one does not usually get it again. The flip side of the coin is that vaccines also work by training this adaptive memory system without one having to go through the actual disease. They are like military drills: safe practice sessions that teach the immune system to recognise and destroy certain pathogens before they get in and cause disease.

Think of your immune system as a vast library filled with records of every infection you have ever encountered. Each record contains information about the specific pathogen and instructions on how to fight it off. When you get a disease or receive a vaccine, new records are added to this library, ensuring that your body is prepared for future encounters.

This phenomenon of Immune Amnesia can occur after certain infections, most famously after contracting the measles virus. In recent years, scientists have come to understand this strange and troubling side effect of an illness that many once believed was simply “a childhood rite of passage.” Measles is not just a fever followed by a rash. It is one of the most contagious diseases known to man, and it can have long-lasting effects on the immune system, even after recovery. Studies in the last decade have shown that measles can erase 20% to 70% of the immune system’s memory. In other words, if you’ve had 100 disease-fighting memory cells, measles might destroy even up to 70 of them. As to how measles does it? Scientists believe that the virus attacks Immune Memory B cells and Memory T cells; these being the two types of specialised immune cells in the body that remember how to fight past infections. Once these cells are damaged or destroyed, your body has to start over from scratch, relearning how to fight infections it already knew how to handle before the “wiping out” of the process.

The really creepy part is that Immune Amnesia does not make you feel sick right away. You may feel perfectly fine after recovering from measles or a similar infection. But your immune system is now more vulnerable. A child who gets measles might recover from the rash and fever. But in the months or years that follow, they could get pneumonia, ear infections, or diarrhoea far more easily than before. These secondary infections can be dangerous, even fatal. In fact, before widespread vaccination, measles did not just kill children through the measles virus itself. Many died from other infections they caught in the months after measles had wiped out their immune memory. That is the reason why countries that introduced the measles vaccine not only saw a drop in measles cases, but also a drop in deaths from other diseases. It turns out that protecting against measles was protecting against a whole range of infections by safeguarding the memory of the immune system.

While measles is the best-known cause of immune amnesia, some scientists are exploring whether other infections might cause similar problems. There’s growing curiosity about whether certain viruses, like the flu viruses or even COVID-19, might temporarily reduce immune memory or even cause immune “confusion”, the latter term referring to a confused immune system attacking normal human tissues or exhibiting less effective responses against disease-causing organisms. While the research is still in early stages, one thing is clear: our immune systems are delicate. Some infections do not just challenge the body, they even rearrange the entire system.

This is where the conversation comes full circle. Vaccination is not just about avoiding a rash or a few days of fever. It is about protecting the long-term memory of your immune system. If you prevent measles through vaccination, you do not just avoid one disease. You also prevent your immune system from being reset and losing its ability to fight off dozens of others. This is why experts emphasise the importance of the measles, mumps, and rubella (MMR) vaccine. Despite its safety and effectiveness, some specific communities and groups of anti-vaxxers have become hesitant or sceptical about vaccines, often due to misinformation and disinformation. But studies have shown that in communities where vaccination rates drop, not only does measles come back, but so do many other infections. It is just like pulling a thread and watching an entire sweater unravel and disintegrate.

Immune amnesia also has consequences for entire populations, not just individuals. When a community is mostly vaccinated, herd immunity kicks in. This means that even people who cannot get vaccinated, like little babies or those with weak immune systems, are protected because the disease has nowhere to spread. But when vaccination rates fall and diseases like measles spread, immune amnesia weakens the immune systems of those who get infected. This creates a ripple effect where many other infections spread more easily, even to people who never had measles. In other words, immune amnesia can help fuel epidemics of other diseases. That is a very heavy price to pay for skipping a simple vaccine.

Immune amnesia is not just a curious biological fact. It is not just another strange scientific fact that might just blow away. It has very serious implications for public health. It could explain why some people get sick more often after recovering from certain infections, and it adds weight to the importance of vaccinations.

The good news is, immune amnesia can be prevented, and the solution is quite a bit straightforward. ONE CLEAR POSITIVE STEP IS TO GET VACCINATED AGAINST DISEASES, PARTICULARLY THOSE THAT ARE KNOWN TO INDUCE IMMUNE AMNESIA. This is particularly important against measles. We need to educate the general public, and this article is a committed attempt to do just that. The society at large should intensely support the public health measures undertaken to facilitate satisfactory vaccination initiatives. If the general public has some concerns regarding vaccines and vaccination, they should promptly ask relevant questions from the proper authorities. It would be most unwise to be guided by portals such as social media.

The World Health Organisation (WHO) recently reported that measles cases in the European region more than doubled from 2023 to 2024, reaching about 127,000, the highest number since 1997. The increase has been linked to a lack of vaccination coverage. It is estimated that half a million children across some parts of the world, which comprises 53 countries in Europe and Central Asia, missed their first dose of the measles vaccine in 2023. Children aged 5 years or younger accounted for about 2 out of 5 cases of the highly transmissible infectious virus.

Immune amnesia is a powerful reminder of how interconnected our health profile really is. One little bug can undo years of carefully crafted immune protection, making the body forget how to fight off old foes. Measles is the best-known example, but scientists are watching for other culprits. The takeaway message is very clear: diseases like measles are not harmless childhood illnesses. They can cause long-term damage, even after the obvious symptoms are gone. Vaccines protect us not just from the disease, but from its deeper and widespread consequences, including Immune Amnesia. So, the next time you think of measles as just a spotty rash, remember that it also can wipe the slate clean, leaving your immune system defenceless and your body at woeful risk.

BY Dr B. J. C. Perera 
MBBS(Cey), DCH(Cey), DCH(Eng), MD(Paed), MRCP(UK), FRCP(Edin), FRCP(Lond), FRCPCH(UK), FSLCPaed, FCCP, Hony. FRCPCH(UK), Hony. FCGP(SL)

Specialist Consultant Paediatrician and Honorary Senior Fellow of the Postgraduate Institute of Medicine, University of Colombo, Sri Lanka.

Joint Editor, Sri Lanka Journal of Child HealthSection Editor, Ceylon Medical Journal



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Opinion

KOICA – Volunteer Partner’s Day Meeting 2025

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On 20th May 2025, KOICA Volunteer Partner’s Day of year 2025 was held at the Courtyard by Marriott with the presence of the Country Director of KOICA Sri Lanka office Mrs. LEE Yooli, Mr. Samantha Bandara, the Director General of External Resources Department and officials from the Department of Technical Education & Training, National Institute of Education, Schools, Universities, National Youth Services Council, Colombo Public Library and over fifteen (15) volunteer partner organization representatives in Sri Lanka.

At present, there are thirteen (13) KOICA volunteers serving in Sri Lanka and the meeting organized by KOICA (WFK Division) was to share the know-how, experience and knowledgeable resources with the respective partner organizations. The main goals of the knowledge sharing session were to deliver relevant information about the KOICA Volunteer program and to generate insights from the partner organizations that will be useful in recalibrating WFK program’s future direction, including safety and security.

During the session, participants of partner organizations showed their strong need to obtain the services of volunteers, especially for the fields of Korean Language, ICT, Electronics, Social Welfare, Electronics and Auto-Mobile Engineering. Furthermore, they appreciated and emphasized the importance of expanding of KOICA Volunteer Program to rural areas in Sri Lanka.

Since the initiation of KOICA Sri Lanka office in 1991, volunteer dispatch activities have taken place throughout most regions in the country. There has been a significant demand for KOICA volunteers in the educational sphere targeting areas of Korean Language, ICT, etc. The expertise received from Korea has not only shown developmental potential in partner organizations but has also provided invaluable expertise for the youth to excel in the job market.

The Country Director of KOICA Sri Lanka office Mrs. LEE YOOLI expressed her gratitude to all the participants of partner organizations and added “KOICA Headquarters, together with the Sri Lanka Office, is pleased to continue the volunteer program under its ODA endeavors towards Sri Lanka; while introducing new focused volunteer fields in alignment with the SDG goals and the Sri Lankan government priorities.”

In the meeting, Mr. Samantha Bandara, Director General of the External Resources Department, extended his deep appreciation to KOICA for overall technical cooperation towards Sri Lanka and especially, appreciated the services of volunteers who contribute for the social and economic growth of the country, by sharing their expertise and Korea’s development experience.

The Korea International Cooperation Agency (KOICA), the grant aid division of the Embassy of the Republic of Korea, is the Korean government agency for grant aids under the mission of “Contributing to the common prosperity and the promotion of world peace through inclusive, mutual development cooperation leaving no one behind.”

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Opinion

Has AKD lost the plot?

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The election of the JVP/NPP leader as the executive president of Sri Lanka was no doubt momentous, perhaps, second only to the election of Ranasinghe Premadasa to the same coveted position. Though it was the first time the ‘caste barrier’ was broken, unfortunately, instead of hailing this social revolution Premadasa had other ideas; he attempted to rewrite history by attempting to change his heritage thus missing a great opportunity to show that Sri Lanka indeed was a country of equality and opportunity! AKD shares with Premadasa the same great achievement of reaching the top from very humble beginnings. In addition, AKD is the only leader of the country to be elected from a party with a ‘terrorist’ heritage and many were hopeful that this would not be a baggage. As recent events have shown, it looks as if he is not able to shed that baggage. It is said that a leopard cannot change its spots! This is past repeating itself, as well illustrated by the actions of our first executive president JRJ; he was a manoeuvrer who could not stop doing so, even when he reached the top, which no doubt contributed to his downfall!

AKD started well, just like all his predecessors have done, but wheels seem to be coming off the wagon pretty soon! He continues to behave like an opposition politician continuing with attacks on his opponents, past and present, instead of concentrating on statecraft, to take action to alleviate the suffering of the masses burdened with severe economic hardships and chart a course for future prosperity. Perhaps, this may at least be partly due to his having to face election after election but this should not be an excuse. Prior to the presidential election he portrayed that he was surrounded by groups of experts, of all modalities, who were ready with policies for rapid implementation but these experts seem to have disappeared into thin air! Only experts in economics seem to be from the much-maligned IMF. The message from the voters seems to be falling on deaf ears as shown by absurd explanations given for the erosion of the vote at the last local government elections.

He seems to be a one-man band which, worryingly, dashes hope for the long-promised abolition of the presidency. He would be totally ineffective without the executive powers of the presidency. This seems yet another addition to his unfulfilled promises. He is apparently being supported by a group of amateurs! Prior to elections there was much hype about the PM, a respected academic, who seems to have been pushed to the background. She does not seem to be functioning efficiently even as the minister of education. Ragging continues in universities resulting in suicides. Even worse was the suicide of a student sexually molested by a teacher, humiliated by a friend of the accused teacher, a private tutor who contested on the NPP ticket. The initial punishment for the teacher, till public protests erupted, was a transfer to a distant school. To make a terrible situation even worse was the action of the minister tasked with ensuring the safety of women and children. She claimed that the parents had not met her and handed over a petition.

This lack of leadership is replicated by the President himself. AKD’s mantra during the parliamentary election campaign was cleansing of Diyawannawa but no sooner had the guardian of the house been elected than his doctorate from a private Japanese university was questioned. After much hesitation, the speaker resigned, claiming that he would prove his academic qualifications. He has not done so and he is still an ‘honourable’ MP! Another MP, a female lawyer had the audacity to state that under the NPP government anyone was free to lie and admitted that she had lied about billions of dollars airlifted to Uganda by the Rajapaksas! AKD has taken no action against these MPs.

AKD also had an exposition of the Sacred Tooth Relic to be held in the run-up to the recent local elections. It did not pay dividends may be because the arrangements were in shambles. He visited Vietnam to deliver a lecture for the International Vesak Day but apparently did not find time to pay homage to the Buddha’s sacred relics on display a short distance away from the conference hall. He did find time to lay a wreath at the memorial of the war dead and flew back on a private jet so that he could vote in the LG elections! Another promise broken but it is claimed that a Buddhist society had paid for the private jet!

AKD’s actions regarding the ceremony to remember and honour war heroes clearly shows that he has completely lost the plot. To the shock and horror of all patriotic Sri Lankans, an announcement was made a couple of days ago by the secretary of defence that the ceremony would be presided over by the deputy minister of defence! In short, the commander of the forces is too busy or too reluctant to attend the remembrance of those who sacrificed their lives for the integrity of the country. I doubt it has happened in any country! If he was of the opinion that this event was superfluous or that it hampered reconciliation, he should have had the guts to issue a statement to that effect. Coming from a ‘terrorist’ heritage, the JVP may be having a soft corner for the terrorists killed by the armed forces and may have thought it was hypocritical for him to attend!

As the public outcry could not be patched over, he decided not only to attend the ceremony but also visit the disabled and allow them to take selfies. It is a shame that AKD seems to have developed selective amnesia for his past statements. During the time Rajapaksas were leading the campaign to eradicate the Tigers, AKD was a strong supporter and at times claimed that he told them what to do! What has brought about this change? Was it the backing from the pro-LTTE groups in other countries?

To add insult to injury, during his speech he alluded that the ‘war’ had been fought for political gains. Though it may have produced political gains, doesn’t he realise that it was fought, at a tremendous cost, to defeat terrorism for the purpose of continuing the integrity of the country? He and his acolytes are spreading the canard that this is different as we did not fight a foreign country. Had the Tigers succeeded, we may well be fighting a different country in our little island! His virtual equation of dead terrorists to our fallen heroes added further insult.

Unfortunately, we seem an ungrateful country insulting our fallen war heroes and allowing hypocritical Western nations insulting our living heroes.

by Dr Upul Wijayawardhana

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Opinion

Make Sri Lanka Great

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Sri Lanka holds immense untapped economic potential, bolstered by its strategic location along major global trade routes, rich natural resources, and a vibrant cultural heritage. Yet, despite these advantages, the nation has faced significant setbacks in recent decades—civil conflict, political instability, economic mismanagement, and rising poverty. Against this backdrop, the call to “Make Sri Lanka Great” is more than a slogan; it is a mission. It represents a collective vision to restore economic stability, promote inclusive growth, and unlock a future of opportunity for all Sri Lankans.

Reclaiming Sri Lanka’s Historical Greatness

Historically, Sri Lanka was a flourishing centre of commerce, education, and cultural exchange in the Indian Ocean. Its location between East and West positioned it as a maritime trade hub linking Asia, the Middle East, and Europe. Ports such as Colombo, Galle, Trincomalee, KKS connected global traders, scholars, and travelers, fostering a dynamic and prosperous economy.

Today, reviving this legacy is crucial. Economic renewal must be anchored in a fusion of historical insight, national unity, and bold innovation. To move forward, Sri Lanka must:

*  Reclaim its legacy of knowledge, resilience, and productivity.

*  Promote confidence in its global economic potential, encouraging innovation, entrepreneurship, and investment.

*  Ensure social inclusion, recognising that unity across ethnic and religious lines is foundational to sustainable growth.

By leveraging its geographic strengths, investing in human capital, and creating a transparent, investor-friendly environment, Sri Lanka can once again become a leading player in regional and global trade.

Economic Challenges

Sri Lanka’s development path is obstructed by a complex web of systemic challenges. An ongoing economic crisis—driven by high debt, poor fiscal discipline, and import dependency—has caused inflation, job losses, and currency depreciation. Political instability and inconsistent policymaking further undermine investor confidence and long-term planning.

Social divisions, rooted in a civil war that ended in 2009, continue to impact national unity. Additionally, youth unemployment and the outmigration of skilled workers are weakening the nation’s human capital. Environmental degradation through deforestation, pollution, and unregulated urbanisation threatens tourism, agriculture, and long-term resilience. Addressing these interconnected issues is essential to laying a foundation for economic recovery and sustainable progress.

A New National Vision

To become truly great, Sri Lanka must redefine development beyond GDP and infrastructure. A developed Sri Lanka should be:

*  Economically strong, with robust industries in technology, tourism, agriculture, and services.

*  Socially cohesive, where every citizen is treated equally and with dignity.

*  Globally respected, as a democratic, peaceful, and environmentally responsible nation.

· Empowering to youth, offering them opportunities to succeed at home, not just abroad.

Foreign-to-Local Citizen Ratios

The Foreign-to-Local Citizen Ratio is more than just a demographic statistic — it serves as a valuable indicator of a country’s openness, safety, and attractiveness to the global community. A healthy ratio often reflects a nation’s ability to provide freedom, security, and economic opportunity to foreigners who visit, live, work, or invest. (See Table)

Foreign-to-Local Citizen Ratios

For example, Singapore’s 44% foreign-to-local ratio has supported its rise as a financial and innovation hub by filling labour gaps and driving productivity. While Sri Lanka’s 1.3% ratio reflects low foreign participation, strategic immigration and talent attraction could contribute to economic revitalisation.

Singapore, the UAE, and Germany have higher foreign-to-local ratios, signaling environments where international residents feel safe, welcomed, and empowered. These nations offer stable governance, clear legal frameworks, and strong institutions that attract foreign workers, investors, and entrepreneurs.

A favourable ratio also shows that a country:

*  Ensures security and legal protection for foreigners.

*  Provides infrastructure and services that support international living and business.

*  Encourages foreign direct investment (FDI) and startup ecosystems by reducing red tape and fostering trust.

*  Embraces cultural diversity, creating a dynamic and innovative society.

For Sri Lanka, improving its foreign-to-local ratio can boost its global reputation as a safe, business-friendly, and forward-looking nation. By creating an environment where foreigners feel confident to visit, reside, invest, and contribute, the country can unlock new economic opportunities and accelerate its journey toward sustainable development.

Economic Renewal

To make Sri Lanka great, a comprehensive strategy is required:

*  Good Governance: Eliminate corruption, strengthen democratic institutions, and promote transparency and rule of law.

*  Economic Transformation: Support local production, SMEs, and ethical foreign investment. Create a resilient, diversified, and export-oriented economy.

*  Education and Skills: Modernise the education system to meet future job demands, especially in IT, engineering, tourism, and creative sectors. Expand vocational training to empower youth.

*  Social Inclusion and Reconciliation: Promote national unity through inclusive governance, equal rights, and decentralis`ation to ensure all regions benefit from development.

*  Environmental Sustainability: Invest in clean energy, eco-tourism, and sustainable agriculture. Protect forests, oceans, and heritage sites to maintain long-term economic and ecological balance.

*  Fiscal and Institutional Reform: Improve tax systems, streamline public spending, and create a stable investment environment to manage debt and rebuild confidence.

*  Knowledge Economy: Position Sri Lanka as a digital hub in South Asia by investing in R&D, digital infrastructure, and innovation ecosystems.

Conclusion

The country has the potential to follow the path of nations like South Korea, Japan, and Singapore — countries that transformed crisis into opportunity through strong leadership, national unity, and long-term reform. To achieve this, Sri Lanka must embrace good governance, invest in human capital, promote entrepreneurship, and prioritise sustainable development. The nation’s future greatness depends on bold economic transformation rooted in its unique strengths. With a clear vision, inclusive policies, and collective commitment, Sri Lanka can rise above its challenges and secure a peaceful, prosperous, and globally respected future.

Visvalingam Muralithas is a researcher in the legislative sector, specializing in policy analysis and economic research. He is currently pursuing a PhD in Economics at the University of Colombo, with a research focus on governance, development, and sustainable growth. He holds a Bachelor of Arts in Economics (Honours) from the University of Jaffna and a Master’s degree in Economics from the University of Colombo.

by Visvalingam Muralithas

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