Latest News
Cabinet gives green light for Colombo Port City Order No. 3 of 2023 to be presented in Parliament
The President in his capacity as the Minister of Investment Promotion has published the Colombo Port City Orders No. 3 of 2023 (Enterprises with Strategic Value – Guidelines for releasing or encouraging to award for customs – free enterprises) under the provisions of the Colombo Port City Economic Commission Act No. 11 of 2021 by the extraordinary gazette notification No. 2355/30 dated 25.10.2023.
The Cabinet of Ministers granted approval to the proposal furnished by the Hon. President in his capacity as the Minister of Investment Promotions to submit the said orders to the Parliament for its concurrence.
(PMD)
Latest News
Nobel Prize in Physiology or Medicine goes to microRNA researchers
The Nobel Prize in Physiology or Medicine 2024 has been awarded to US scientists Victor Ambros and Gary Ruvkun for their work on microRNA.
Their discoveries help explain how complex life emerged on Earth and how the human body is made up of a wide variety of different tissues.
MicroRNAs influence how genes – the instructions for life – are controlled inside organisms, including us.
The winners share a prize fund worth 11m Swedish kronor (£810,000).
Every cell in the human body contains the same raw genetic information, locked in our DNA.
However, despite starting with the identical genetic information, the cells of the human body are wildly different in form and function.
The electrical impulses of nerve cells are distinct from the rhythmic beating of heart cells. The metabolic powerhouse that is a liver cell is distinct to a kidney cell, which filters urea out of the blood. The light-sensing abilities of cells in the retina are different in skillset to white blood cells that produce antibodies to fight infection.
So much variety can arise from the same starting material because of gene expression.
The US scientists were the first to discover microRNAs and how they exerted control on how genes are expressed differently in different tissues.
The medicine and physiology prize winners are selected by the Nobel Assembly of Sweden’s Karolinska Institute.
They said: “Their groundbreaking discovery revealed a completely new principle of gene regulation that turned out to be essential for multicellular organisms, including humans.
“It is now known that the human genome codes for over 1,000 microRNAs.”
Without the ability to control gene expression, every cell in an organism would be identical, so microRNAs helped enable the evolution of complex life forms.
Abnormal regulation by microRNAs can contribute to cancer and to some conditions, including congenital hearing loss and bone disorders.
A severe example is DICER1 syndrome, which leads to cancer in a variety of tissues, and is caused by mutations that affect microRNAs.
Prof Ambros, 70, works at the University of Massachusetts Medical School, and Prof Ruvkun, 72, is a professor at Harvard Medical School.
Both conducted their research on the nematode worm – C. elegans.
They experimented on a mutant form of the worm that failed to develop some cell types, and eventually homed in on tiny pieces of genetic material or microRNAs that were essential for the worms’ development.
This is how it works:
- A gene or genetic instruction is contained within our DNA
- Our cells make a copy, which is called messenger RNA or simply mRNA (you’ll remember this from Covid vaccines)
- This travels out of the cell’s nucleus and instructs the cell’s protein-making factories to start making a specific protein
- But microRNAs get in the way by sticking to the messenger RNA and stop it working
- In essence the mircoRNA has prevented the gene from being expressed in the cell
Further work showed this was not a process unique to worms, but was a core component of life on Earth.
Prof Janosch Heller, from Dublin City University, said he was “delighted” to hear the prize had gone to Profs Ambros and Ruvkun. “Their pioneering work into gene regulation by microRNAs paved the way for groundbreaking research into novel therapies for devastating diseases such as epilepsy, but also opened our eyes to the wonderful machinery that is tightly controlling what is happening in our cells.”
Previous winners
2023 – Katalin Kariko and Drew Weissman for developing the technology that led to the mRNA Covid vaccines.
2022 – Svante Paabo for his work on human evolution.
2021 – David Julius and Ardem Patapoutian for their work on how the body senses touch and temperature.
2020 – Michael Houghton, Harvey Alter and Charles Rice for the discovery of the virus Hepatitis C.
2019 – Sir Peter Ratcliffe, William Kaelin and Gregg Semenza for discovering how cells sense and adapt to oxygen levels.
2018 – James P Allison and Tasuku Honjo for discovering how to fight cancer using the body’s immune system.
2017- Jeffrey Hall, Michael Rosbash and Michael Young for unravelling how bodies keep a circadian rhythm on body clock.
2016 – Yoshinori Ohsumi for discovering how cells remain healthy by recycling waste.
[BBC]
Latest News
Sciver-Brunt and Ecclestone lead England to classy victory
Nat Sciver-Brunt produced one of the innings of the Women’s T20 World Cup so far to guide England home in the final over, against South Africa. Her 48 not out was not only the most substantial of the match, it was also the most aggressive, coming off 36 deliveries.
It was Sciver-Brunt’s 64-run stand with Danni Wyatt-Hodge that swung the match decisively in England’s favour, as they pursued a target of 125.
South Africa’s spinners had been valiant, particularly Nonkululeko Mlaba, who took 1 for 22 from her four overs. But with England’s strong batting line-up, they needed more of the chances the bowlers created to be taken. South Africa could not capitalise on two half-chances offered by Wyatt-Hodge, and though Sciver-Brunt rode her luck to some extent too, none of the mis-hits went to fielders.
The win leaves England in a strong position to qualify for the semi-finals, with two wins from two and a solid net run rate of 0.653. South Africa have more work to do.
Although England had been careful not to lose wickets early on, they required an injection of energy through the middle overs to set them properly on course for victory, and Sciver-Brunt was the woman to provide it. She was immediately dynamic at the crease, hitting her fourth ball for four behind square on the offside, before settling into her usual rhythm of picking runs through the legside.
She would frequently shuffle to off and target the square leg boundary against the spinners, even if, on such a slow surface, she didn’t always find the timing. She hit 32 of her runs in the arc between fine leg and deep midwicket, scoring four boundaries in that direction.
Though Wyatt-Hodge was stumped with 11 still to get off 12 deliveries, Sciver-Brunt struck a four in each of the last two overs, and iced the game.
Between them, left-arm spinner Sophie Ecclestone legspinner Sarah Glenn, and offspinner Charlie Dean bowled 12 overs for 58 runs, and took four wickets. Linsey Smith, also a left-arm spinner, took 1 for 32 off her four overs too.
But it was the tight, varied bowling of Ecclestone and Glenn that really kept the scoring down through the middle overs. Ecclestone got the two biggest opposition wickets – bowling Laura Wolvaardt in the 16th over, before crashing another one into the stumps of an advancing Marizanne Kapp int he 19th over. She finished with figures of 2 for 15 from her four – the best returns in the game.
She’d started so strongly. South Africa’s captain won the toss in what was an obviously bat-first situation, and looked excellent in the powerplay, in which she scored 22 off 15 balls, helping take South Africa to a healthy 37 for 1. But then England’s spinners applied the brakes, and she was unable to find the boundary for the remainder of her innings, which went until the 16th over. She maintained a decent scoring rate thanks to her singles and twos, but against a batting order of England’s quality, South Africa needed a score in the vicinity of 150 to feel safe.
Then, in the field, she let two half-chances off Wyatt-Hodge slip through her outstretched fingers, the first of those let-offs coming when the batter was on only 8.
Still, Wolvaardt’s was the most substantial of South Africa’s individual contributions – she made 42 off 39.
Brief scores:
England Women 125 for 3 in 19.2 overs (Nat Sciver-Brunt 48*, Dani Wyatt-Hodge 43; Marizanne Kapp 1-17, Nonkululeko Mlaba 1-22, Nadine de Klerk 1-23) beat South Africa Women 124 for 6 in 20 overs (Laura Wolvaardt 42, Marizanne Kapp 26,Annerie Dercksen 20*; Linsey Smith 1-32, Charlie Dean 1-25, Sophie Ecclestone 2-15, Sarah Glenn 1-18) by seven wickets
[Cricinfo]
Business
ADB delegation meets President Dissanayake, pledges continued support for Sri Lanka’s economic development
The Country Director of the Asian Development Bank (ADB) Resident Mission in Sri Lanka, Takafumi Kadono, along with a delegation, met President Anura Kumara Dissanayake today (07) at the Presidential Secretariat.
During the discussion, which focused on ADB’s ongoing commitment to support Sri Lanka’s economic and social development, the ADB reaffirmed its dedication to continuing its projects in Sri Lanka, with particular emphasis on bolstering key sectors crucial to the nation’s recovery. Tourism was identified as a critical sector that holds immense potential for Sri Lanka’s economic growth. In this regard, the ADB assured further assistance in developing tourism infrastructure to harness the sector’s full potential.
President Dissanayake highlighted the importance of promoting tourism in the Northern Region, requesting ADB’s specific support to develop this area. The ADB delegation expressed its willingness to collaborate and provide resources for this initiative.
Beyond tourism, the ADB also expressed keen interest in aiding the development of Sri Lanka’s energy sector, small-scale entrepreneurs, and financial sector, emphasizing their role in fostering sustainable economic growth.
This continued collaboration between Sri Lanka and the ADB is expected to contribute significantly to the country’s long-term development and recovery efforts.
Mr. Takafumi Kadono, Country Director ADB, Ms. Cholpon Mambetova, Country Operations Head ADB, Ms. Hasitha Wickremasinghe, Senior Economics Officer, Mr. K.M. Mahinda Siriwardana, Secretary to the Treasury and Ministry of Finance, Economic Stabilization and National Policies, Mr. D.A.P. Abesekara, Director General Finance Ministry and Ms. Udeni Udugahapattuwa, Director Finance Ministry, were present at the meeting.
[PMD]
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