To fight COVID-19 is to fight its lightning transmission



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by Rajan Philips


The consensus within the medical scientific community cannot be clearer. There is no medication to treat the Coronavirus Disease of 2019 (COVID-19). And there is no vaccine to prevent it. The only weapon against the disease that is available for the next several weeks, even months, is to reduce or prevent community transmission of the virus. All the data on human to human transmission of the virus indicates that transmission occurs primarily through respiratory droplets from coughing and sneezing between individuals in close contact. And transmission is also occurring at significant levels through ‘asymptomatic’, virus carriers without any symptom. Therefore, social isolation is the only way to prevent disease transmission in the foreseeable near to medium term.


The scale at which isolation should be conducted in every country is astounding and unprecedented. The effects of such isolation will be crippling on national economies and the world economy as a whole. Governments everywhere are facing two massive challenges, and all at the same time, like never before. Governmental capabilities and capacities to respond to the twin challenges vastly differ from country to country. Different countries like China, Italy and South Korea, with large numbers of caseloads have tried different degrees and methods of isolation with dramatically different results. The US and the British governments took too cavalier an approach to COVID-19 for far too long, and are now scrambling to stem the inevitable surge in the number of cases that is widely expected in both countries.


Sri Lankan authorities too were showing signs of nonchalance, bravado, and political calculations, but learnt their lesson rather quickly, in a matter of three days. After summarily rejecting calls to postpone the April parliamentary elections, the authorities hurriedly decided to postpone them indefinitely soon after nominations closed. And after spurning suggestions to implement a national clampdown to enforce social isolation, the government declared emergency and imposed national curfew over the weekend from Friday evening to Monday morning. It has since been extended till Tuesday for a number of districts. The government has also banned pilgrimages, tours and leisure trips, called upon people to maintain a safe one metre distance between them, and ordered trains and buses to restrict passenger loads to half their seat capacity. These are all positive and necessary steps, but much more needs to be done consistently to prevent an exponential rise in the number of cases in Sri Lanka.


The global and national increases in the number of cases between Friday, 13 March, and Saturday 21 March, are scary. The global total has almost tripled from 136,875 cases to 315,414 cases and 13,591 deaths. Only China and South Korea are showing some stabilization, around 81,000 and 8,900 cases, respectively. Everywhere else, the virus has gone exponential. The dramatic increases are in Western Europe, and the US total has risen from 1,264 to 26,900. South Asia, South America and Africa are no longer the spared oases they looked last week. India is up from 81 to 341 while Pakistan has vaulted to 730 from 20. Bangladesh (3 to 27) and the Maldives (8 to 13) are holding steady for now. In Sri Lanka, the number of known cases has worryingly multiplied from 3 to 80 in one week. More worryingly, there are reportedly unaccounted arrivals from overseas before the current airport restrictions began, and who might potentially be virus carriers within the general population.


Having great doctors and good hospitals is not enough in any country if the coronaviral disease surges beyond the country’s overall healthcare capacity. The healthcare problem for Sri Lanka is not the quality of its professionals but the capacity of its healthcare infrastructure. If the number of COVID-19 cases is allowed to increase to the point of overwhelming its healthcare capacity, the country will be in deep trouble. The system will have to cope with not only increasing numbers of COVID-19 patients, but also normal patients requiring hospital treatment.


Given the relatively high proportion of elderly in the island’s population, it will be a challenge to protect them from the virus and then treat them if they get infected. Limited capacity and overwhelming demand would mean doctors will be forced to perform the dreadful task of triaging – deciding the order of allocating limited number of beds, especially ICU beds, among a large number of patients. And doctors and nurses will end up getting infected and worse. These are not scare stories but are already happening in Italy and in Iran.


Flattening the curve


There is an amazing array of scholarly scientific writings dealing with practically every aspect of the Coronavirus that is appearing online and in real time. The two graphs (above) are among the hundreds that are in circulation, illustrating the now universal mantra of ‘flattening the curve’. They are based on simple mathematical models and are useful in illustrating the concept and its consequence for healthcare capacity.


The above set of graphs illustrate how the number of COVID-19 cases will rise, peak and fall under three conditions, viz., without any slowing down of disease transmission, with transmission reduced by 20%, and transmission reduced by 40%. Reducing the spread of the disease lowers the maximum number of cases while extending the duration of the epidemic, to manageable levels.


The second set of graphs shows what is manageable. By slowing down the disease spread, the maximum number of cases in a country, or in areas within it, can be brought within its healthcare capacity - the number of hospitals, beds, ICU beds, care workers and professionals, and equipment. The failure to arrest the disease early on led to surges in China, Korea, Italy and now other West European countries, overwhelming their healthcare capacities. While China and Korea may have, hopefully, seen the worst off, others in that league are still struggling.


Italy, especially northern Italy, has not been able to stem the spread at all despite a national shutdown for now over two weeks. With rapidly rising number (53,578) of cases, 793 of them dying in a single day on Saturday, Italy provides the tragically classic case of both struggling to contain the disease and creating the surge capacity to treat the ballooning number of patients. Specific to COVID-19 and its treatment, Italian doctors have found that antivirals or other drugs are not working; what is apparently working is the ventilating of patients while keeping them facedown. Hence the dire need for ICU beds and ventilators in hospitals to pump oxygen into the lungs of COVID-19 patients whose signature symptom is difficulty in breathing.


There are only four ventilator manufactures in Europe, and one of them is in Italy. All exports of ventilators and other emergency equipment are now banned, and this will create downstream problems in importing countries. For example, Vietnam, India, Korea and the Philippines have all paid for and were expecting delivery of 320 ventilators in total among them from Italy. But Italy’s sole manufacturer of ventilators, Siare Engineering International, has cancelled the exports and distributed the machines internally. Italy is not able to get any supplementary supply from EU countries, who are having the same problem. China has committed to supply 1,000 ventilators to Italy.


Western countries are finally fearing the worst and are directing their manufacturers to retool their assembly lines to produce ventilators and other emergency medical equipment in large numbers and in short order. In the US, the military has resources to produce temporary hospitals to provide surge capacity, and there are about 10 ventilator manufacturers. But equipment supply continues to be a problem, especially emergency equipment for healthcare professionals. The US government has ordered modifying masks manufactured for construction workers to supply hospital personnel. That has instantly increased the supply from three million to 35 million, but getting them across to hospitals is still a challenge.


During the SARS crisis in Canada, over 40% of those who died were healthcare professionals. It has been reported that in the current COVID-19 outbreak, no healthcare professional has been infected in Singapore, Taiwan, or Hong Kong. In Italy and Iran, on the other hand, doctors are treating fellow doctors as COVID-19 patients.


Data from China, Italy and the US also show that no age group is particularly safe even though the really old and the elderly are the most vulnerable. Data also shows that regardless of age, people with pre-existing medical conditions are vulnerable to COVID-19. In Italy and in the US, all age groups require hospital admission and ICU beds, which adds to the overall demand on healthcare capacity.


There are ongoing clinical trials to repurpose existing antiviral drugs to treat COVID-19 patients. Two that are most mentioned are, an anti-malaria drug, and remdesivir, an Ebola drug. Both are being tried in clinical trials in China, South Korea and France, and chloroquine has apparently "shown promise." There is no conclusive medical opinion on the use of chloroquine anywhere in the world. But Donald Trump has created worldwide confusion by publicly pushing for chloroquine to be widely administered in the US. The search for the vaccine and its eventual finding is still a long process. At the same time, there has never been such a concerted global effort to get a cure or a vaccine as it is being done now to overcome the coronavirus. As always, the prudent principle is to keep preparing for the worst while hoping for the best.


The specialist global watchers of COVID-19 are contrasting the different approaches – the harsh and lockdown approach in China and Italy, on the one hand, and the transparent and public-co-operative approach in South Korea, on the other. South Korea’s massive testing programme has been identified as the "linchpin" of its approach. The testing is either free, if referred by a doctor or displaying symptoms, or available at the affordable (in South Korea) cost of US$135 per test. The massive test programme, data management, disease tracking and selective geographical interventions to isolate patients are the sum of the South Korean response. Similar outcomes have been noted in Taiwan, Hong Kong and Singapore, all of whom along with South Korea are the wiser after their experience with past outbreaks of respiratory diseases like SARS and MERS.


Sri Lanka’s only option in fighting COVID-19 is to go flat out to flatten the curve and to prevent an exponential rise in the number of patients. The government must enlist modelling specialists to assemble disease spread data and develop ‘a curve’ specific to Sri Lanka and use it as guidance to stay ‘ahead of the curve’ as far as possible. Regional variations will have to be accounted for in developing the curve, monitoring the spread, and mobilizing the response. So far, the cases in Sri Lanka appear to be more concentrated in the districts of Gampaha, Colombo and Puttalam. 57% of them are male and 33% of them under 40 years old. The government may have to adopt a blended approach involving necessary harshness and consistent smartness.


Given South Korea’s experience in implementing an extensive testing programme, the Sri Lankan government must do all it can to get South Korean help to administer a similar approach in Sri Lanka. Sri Lanka has reasonably adequate individual and institutional resources for undertaking such a task with outside help. The government would be smart to try that while maintaining maximum social distancing. There should be no let up whatsoever during the upcoming national holiday periods in April and in May.


 
 
 
 
 
 
 
 
 
 
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